|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 2 | Hepatic artery thrombosis after orthotopic liver transplantation: a review of nonsurgical canses显示文摘 | Pastacaldi S Teixeira R Montalto P | 2001 | Liver transplantation2001，7，2： | 1 |
| 3 | Hepatic artery thrombosis after orthotopic liver transplantation:a review of nonsurgical causes显示文摘 | Pastacaldi S Teixeira R Montalto P | 2001 | Liver Transpl2001，7，2： | 1 |
| 4 | He patic artery thrombosis after orthotopic liver transplantation: a review of non surgical causes显示文摘 | Pastacaldi S Teixeira R Montalto P | 2001 | Liver Transpl2001，7，2： | 1 |
| 5 | Hepatic artery thrombosis after orthotopic liver transplantation:a review of nonsurgical causes显示文摘 | Pastacaldi S Teixeira R Montalto P | | 0，，02： | 1 |
| 6 | Hepatic arery thrombosis afte orthotopic liver transplantation:a review of nonsurgical causes显示文摘 | Pastacaldi S Teixeira R Montalto P | 2001 | Liver Transplantation2001，7，： | 1 |
| 7 | Late hepatic artery thrombosis after orthotopic liver transplantation显示文摘 | Gunsar F Rolando N Pastacaldi S | 2003 | Liver Transpl2003，9，6： | 1 |
| 8 | Hepatic artery thrombosis after orthotropic liver transplantation:a review of nonsurgical causes显示文摘 | Pastacaldi S Teixeira R Montalto P | | 0，，： | 1 |
| 9 | Hepatic artery thrombosis after orthotopic liver transplantation: a review of nonsurgical causes显示文摘 | Pastacaldi S Teixeira R Montalto P | 2001 | Liver Transpl2001，7，： | 1 |
| 10 | Late hepatic artery thrombosis after orthotopic liver transplantation显示文摘 | Gunsar F Rolando N Pastacaldi S | 2003 | Liver Transpl2003，9，6： | 1 |
| 11 | Hepatic artery thrombosis after orthotopic liver transplantation: A review of nonsurgical causes显示文摘 | Sabrina Pastacaldi Rosangela Teixeira Paolo Montalto Keith Rolles Andrew K. Burroughs | 2001 | Liver Transplantation2001，，2： | 1 |
| 12 | Hepatic artery thrombosis after orthotopic liver transplantation:a review of nonsurgical causes 显示文摘 | Pastacaldi S Teixeira R Montaho P | 2001 | Liver Transpl2001，7，2： | 1 |
| 13 | Late hepatic artery thrombosis after orthotopic liver transplantation显示文摘 | Gunsar F Rolando N Pastacaldi S | 2003 | Liver Transpl2003，9，6： | 1 |
| 14 | Hepatic artery thrombosis after orthotopic liver transplantation: a review of nonsurgical causes显示文摘 | Pastacaldi S Teixeira R Montaho P | 2001 | Liver Transpl2001，7，2： | 1 |
| 15 | Hepatic artery thrombosis after orthotopic liver transplantation: a review of nonsurgical causes显示文摘 | Pastacaldi S Teixeira R Montalto P | 2001 | Liver Transpl2001，7，2： | 1 |
| 16 | Short term microgravity effect on isometric hand grip and precision pinch force with visual and proprioceptive feedback 显示文摘 | Pastacaldi P Orsini P Bracciaferri F | 2004 | Adv Space Res2004，33，8： | 1 |
| 17 | Agonist-specific regulation of monocyte chemoattractant protein-1 expression by cyclooxygenase metabolites in hepatic stellate cells显示文摘 | Efsen E Bonacchi A Pastacaldi S | 2001 | Hepatology2001，33，： | 1 |
| 18 | Hepatic artery throm- bosis after orthotopic liver transplantation: a review of nonsurgical causes显示文摘 | Pastacaldi S Teixeira R Montalto P | 2001 | Liver Transpl2001，7，2： | 1 |
| 19 | Late hepatic artery thrombosis after orthotopic liver transplantation显示文摘 | Gunsar F Rolando N Pastacaldi S | 2003 | Liver Transpl2003，9，6： | 1 |
| 20 | Hepatic artey thrombosis after orthotopic liver transplantation:a review of nonsurgical causes显示文摘 | Pastacaldi S Teixeira Montalto P | 2001 | Liver Transplant2001，7，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员