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| 1 | Neutrophil depletion-but not prevention of Kupffer cell activation-decreases the severity of cerulein-induced acute pancreatitis显示文摘瞄准:为了决定嗜中性的弄空和 Kupffer 房间抑制是否可能联合,他们的 protective 完成尖锐胰腺炎的严厉到减少。方法:老鼠有 cerulein 管理导致尖锐胰腺炎并且是有任何一个反老鼠 neutrophil 浆液或金轧氯化物(GdCl3 ) 的 pretreated 阻止 Kupffer 房间激活,或两个处理。损害在胰和肺被估计。Myeloperoxidases (军邮局) 估计了嗜中性的渗入。Interleukin-6 (IL-6 ) 和 IL-10 在浆液,胰,肺和肝被测量。结果:在有尖锐胰腺炎的老鼠,嗜中性的弄空减少了胰腺炎和联系胰腺炎的肺损害的严厉。在由 GdCl3 的激活的 Kupffer 房间有更少的保护的效果,尽管 IL-6 和 IL-10 集中显著地被减少。嗜中性的弄空带的普雷茨氏疗法没被 Kupffer 房间在激活提高,两个处理没联合他们的保护的效果。结论:当 Kupffer 房间激活的角色是不太明显的时,我们的结果在在尖锐胰腺炎加重机关损害证实激活的 neutrophils 的角色。 | Catherine M Pastor Alain Vonlaufen Fabianna Georgi Antoine Hadengue Philippe Morel Jean-Louis Frossard | 2006 | World Journal of Gastroenterology2006，12，8： | 22 |
| 2 | Experimental evidence of obesity as a risk factor for severe acute pancreatitis显示文摘The incidence of acute pancreatitis,an inflammation of the pancreas,is increasing worldwide.Pancreatic injury is mild in 80%-90% of patients who recover without complications.The remaining patients may develop a severe disease with local complications such as acinar cell necrosis,abscess and remote organ injury including lung injury.The early prediction of the severity of the disease is an important goal for physicians in management of patients with acute pancreatitis in order to optimize the therapy and to prevent organ dysfunction and local complications.For that purpose,multiple clinical scale scores have been applied to patients with acute pancreatitis.Recently,a new problem has emerged:the increased severity of the disease in obese patients.However,the mechanisms by which obesity increases the severity of acute pancreatitis are unclear.Several hypotheses have been suggested:(1) obese patients have an increased inflammation within the pancreas;(2) obese patients have an increased accumulation of fat within and around the pancreas where necrosis is often located;(3) increase in both peri-and intra-pancreatic fat and inflammatory cells explain the high incidence of pancreatic inflammation and necrosis in obese patients;(4) hepatic dysfunction associated with obesity might enhance the systemic inflammatory response by altering the detoxification of inflammatory mediators;and(5) ventilation/perfusion mismatch leading to hypoxia associated with a low pancreatic flow might reduce the pancreatic oxygenation and further enhance pancreatic injury.Recent experimental investigations also show an increased mortality and morbidity in obese rodents with acute pancreatitis and the implication of the adipokines lep-tin and adiponectin.Such models are important to investigate whether the inflammatory response of the disease is enhanced by obesity.It is exciting to speculate that manipulation of the adipokine milieu has the potential to influence the severity of acute pancreatitis. | Jean-Louis Frossard Pierre Lescuyer Catherine M Pastor | 2009 | World Journal of Gastroenterology2009，15，42： | 14 |
| 3 | 泥石流泛滥区域数值模拟显示文摘概述泥石流泛滥区域数值模拟的研究现状,介绍数值模拟Geoflow程序的基本方程、数值求解方法和定解条件。采用Geoflow程序对四川省境内某一较大泥石流沟遭遇20年一遇泥石流的泛滥区域进行数值模拟,得到的泛滥区域与采用经验公式法得到的结果基本一致,表明数值模拟的结果具有工程应用价值。由于该泥石流沟的重大威胁性,建议在堆积扇上修建的生产、生活设施应避让泛滥区域或采取适当的防护治理措施。 | 李同春 李杨杨 章书成 余斌 Pastor M | 2008 | 水利水电科技进展2008，28，6： | 5 |
| 4 | Acute pancreatitis显示文摘 | Jean-Louis Frossard Michael L Steer Catherine M Pastor | 2008 | The Lancet2008，，9607： | 2 |
| 5 | Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5- FU through mediation of an NF kappaB and microRNA network显示文摘 | Wang B D Kline C L Pastor D M | 2010 | Mol Cancer2010，9，1： | 1 |
| 6 | Response of northern forests to CO2-induced climate change显示文摘 | Pastor J Post W M | 1988 | Nature1988，334，： | 1 |
| 7 | Proliferation and apoptosis of spermatogonia in postpuberal boar ( Sus domesticus )testes with spontaneous unilateral and bilateral abdominal cryptorchidism显示文摘 | BERNAL-MANAS C M MORALES E PASTOR LM | 2005 | Acta Histochem2005，107，5： | 1 |
| 8 | A patch test for mesh alignment effects in localized failure显示文摘 | Pastor M Quecedo M | 1995 | Commun Num Meth Eng1995，11，： | 1 |
| 9 | External arguments in the multiple-spiral medallions of the Mandelbrot set显示文摘 | Romera M Pastor G Alvarez G | | 0，，03： | 1 |
| 10 | Potential applications of laecase in the food industry显示文摘 | Minussi R C Pastore G M Dura N | 2002 | Trends in Food Science & Technology2002，13，： | 1 |
| 11 | Analysis of the influence of pH and pressure on the elimination of boron in reverse osmosis 显示文摘 | D Prats M F Chillon - Arias M Rodriguez - Pastor | 2000 | Desalination2000，128，3： | 1 |
| 12 | Appendicitis in pregnancy显示文摘 | Patricia A Pastore Dianne M | 2006 | JABFM2006，19，6： | 1 |
| 13 | Mechanical properties of triaxially braided composites: experimental and analytical results 显示文摘 | Masters J E Foye R L Pastore C M | 1993 | J Compo Technol Res1993，15，2： | 1 |
| 14 | Versatile chelating behavior of benzil bis (thiosemicarbazone) in zinc, cadmium, and nickel complexes显示文摘 | Lopez-Torres E Mendiola M A Pastor C J | 2004 | Inorg Chem2004，43，17： | 1 |
| 15 | Porosity, underfill ans Magnesium loss during continuous wave Nd:YAG laser welding of thin plates of Aluminium alloy 5182 and 5754显示文摘 | Pastor M Zhao H Martukanitz R P | 1999 | Welding Journal1999，78，6： | 1 |
| 16 | Intraduodenal lipase activity in celiac disease assessed by means of ^13 C mixed triglyceride breath test显示文摘 | Perri F Pastore M Festa V | 1998 | J Pediatr Gastroenterol Nutr1998，7，4： | 1 |
| 17 | Expression of prolactin and prolactin receptors by non-Hodgkin's lymphoma cells显示文摘 | Matera L Geuna M Pastore C | 2000 | Int J Cancer2000，85，1： | 1 |
| 18 | Mechanization process in the production of mescal 显示文摘 | Hector M Duran-Garcia Emilio J Gonzalez- Galv a n Pastor Matadamas-Ort i z | 2007 | Journal of Food Agriculture & Environment2007，5，34： | 1 |
| 19 | Bone autografting of the calvaria and craniofacial skeleton:historical background,surgical results in a series of 15 patients,and review of the literature显示文摘 | FERRANTE L PASTORE F S | 2003 | Surg Neurol2003，60，1： | 1 |
| 20 | An Efficiency Comparison of European Banking Systems Operating under Different Environmental Conditions 显示文摘 | Lozano-Vivas A Pastor J T Pastor J M | 2002 | Journal of Productivity Analysis2002，18，： | 1 |
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