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| 1 | Association of Streptococcus bovis presence in colonic content with advanced colonic lesion显示文摘AIM:To prospectively examine the association between presence of Streptococcus bovis(S.bovis)in colonic suction fluid and the endoscopic findings on colonoscopy.METHODS:From May 2012 to March 2013,203 consecutivepatients who underwent colonoscopy for any reason were enrolled in the study.Exclusion criteria included:antibiotic use in the previous month,age younger than18 years,and inadequate preparation for colonoscopy.The colonoscopy was performed for the total length of the colon or to the occluding tumor.The endoscopic findings were registered.Samples were obtained proximal to the colonoscopic part of the suction tube from each patient and sent to the clinical microbiology laboratory for isolation and identification of S.bovis.Samples were incubated in enrichment media with addition of antibiotic disks for inhibition of growth of Gram-negative rods.The samples were seeded on differential growth media;suspected positive colonies were isolated and identified with Gram staining,catalase,and pyrrolidonyl arylamidase tests,and further identified using a VITEK2 system.Statistical analyses were performed using the Student’s t andχ2 tests.RESULTS:Of the 203 patients recruited,49(24%)patients were found to be S.bovis carriers;of them,the endoscopic findings included:17(34.7%)cases with malignant tumors,11(22.4%)with large polyps,5(10.2%)with medium-sized polyps,6(12.2%)with small polyps,4(8.1%)with colitis,and 6(12.2%)normal colonoscopies.Of 154 patients found negative for S.bovis,the endoscopic findings included:none with malignant tumors,9(5.8%)cases with large polyps,11(7.1%)with medium-sized polyps,26(16.9%)with small polyps,7(4.5%)with colitis,and101(65.6%)normal colonoscopies.S.bovis(Grampositive coccus)is considered part of the normal intestinal flora.There is an association between S.bovis bacteremia and colonic neoplasia.It is not well understood whether the bacterium has a pathogenetic role in the development of neoplasia or constitutes an epiphenomenon of colorectal neoplasms.There was a clear relationship between positivity for S.bovis in colonic suction fluid and findings of malignant tumors and large polyps in the colon.CONCLUSION:There is an association between S.bovis bacteremia and malignant colonic lesions;this should prompt for development of a reliable screening method for advanced colonic lesions. | Maya Paritsky Nina Pastukh Diana Brodsky Natalya Isakovich Avi Peretz | 2015 | World Journal of Gastroenterology2015，21，18： | 9 |
| 2 | Sequence-spe- cific oxidative base modifications in hypoxia-inducible genes显示文摘 | Pastukh V Ruchko M Gorodnya O | 2007 | Free Radic Biol Med2007，43，12： | 1 |
| 3 | Contribution of the PI3-kinase/Akt survival pathway toward osmotic preconditioning 显示文摘 | Pastukh V Ricci C Solodushko V | 2005 | Mol Cell Biochem2005，269，12： | 1 |
| 4 | Reversal of hyperglycemic preconditioning by angiotensin II: role of calcium transport 显示文摘 | Pastukh V Wu S Rieci C | 2005 | AmJ Physiol Heart Circ Physiol2005，288，4： | 1 |
| 5 | Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences 显示文摘 | Viktor M Pastukh Li Zhang | 2011 | International Journal of COPD2011，6，3： | 1 |
| 6 | Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis显示文摘 | Ricci C Pastukh V Leonard J | 2008 | Am J Physiol Cell Physiol2008，294，2： | 1 |
| 7 | Possible cause of taurine-deficient cardiomyopathy:potentiation of angiotensin Ⅱ action显示文摘 | Schaffer S Solodushko V Pastukh V | 2003 | J Cardiovasc Pharmacol2003，41，： | 1 |
| 8 | Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences显示文摘 | Pastukh VM Zhang L Ruchko MV | | 0，，： | 1 |
| 9 | Reversal of Hyperglycemic Preconditioning by Angiotensin Ii : Role of Calcium Transport显示文摘 | Pastukh V Wu S Ricci C | 2005 | Am J Physiol Heart Circ Physiol2005，288，4： | 1 |
| 10 | Possible cause of taurine-deficient cardiomyopathy: potentiation of angiotensin Ⅱ action 显示文摘 | Schaffer S Solodushko V Pastukh V | 2003 | J Cardiovasc Pharmacol2003，41，5： | 1 |
| 11 | Effect of ischemia,calcium depletion and repletion,acidosis and hypoxia on cellular taurine content显示文摘 | Schaffer SW Pastukh V Solodushko V | 2002 | Amino Acids2002，23，4： | 1 |
| 12 | Perinuelear mitechondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription 显示文摘 | A1-Mehdi AB Pastukh VM Swiger BM | 2012 | Sci Signal2012，5，231： | 1 |
| 13 | Human mitochon- drial transcription factor A possesses multiple subcellular targeting signals显示文摘 | Pastukh V Shokolenko I Wang B | 2007 | FEBS J2007，274，24： | 1 |
| 14 | Apoptotic cascade initiated by angiotensin Ⅱ in neonatal cardimyocytes:role of DNA damage 显示文摘 | Grishko V Pastukh V Solodushko V | 2003 | Am J Physiol Heart Circ Physiol2003，285，6： | 1 |
| 15 | Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences显示文摘 | Pastukh VM Zhang L Ruchko MV | | 0，，： | 1 |
| 16 | Insulin withdrawal induces apoptosis via a free radical-mediated mechanism显示文摘 | Ricci C Pastukh V Mozaffari M | 2007 | Can J Physiol Pharmacol2007，85，34： | 1 |
| 17 | Apoptotic cascade initiated by angiotensinll in neonatal cardiomyocytes: role of DNA damage显示文摘 | Grishko V Pastukh V Solodushko V | 2003 | Am J Physiol Heart Circ Physiol2003，285，6： | 1 |
| 18 | Apoptotic cascadeinitiated by angiotensin II in neonatal cardiomyocytes: role of DNAdamage显示文摘 | Grishko V Pastukh V Solodushko V | 2003 | Am J Physiol Heart Circ Physiol2003，285，： | 1 |
| 19 | alpha-complementation-enabled T7 expression vectors and their use for the expression of recombinant polypeptides for protein transduction experiments显示文摘 | Alexeyev MF Pastukh VV Shokolenko IN | 2004 | Methods Mol Biol2004，267，： | 1 |
| 20 | Apoptotic cascade initiated by angiotensin Ⅱ in neonatal cardiomyocytes:role of DNA damage显示文摘 | Grishko V Pastukh V Solodushko V | 2003 | Am J Physiol2003，285，6： | 1 |
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