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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 3 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 4 | Rare presentation of primary (AL) amyloidosis as gastrointestinal hemorrhage without systemic involvement显示文摘We are reporting a rare case of a patient with primary(AL) amyloidosis presenting with an acute non-varicealupper gastrointestinal hemorrhage in the absence ofother systemic involvement. The case report involves a58-year-old woman with significant cardiac history andhereditary blood disorder who came in complaining ofabdominal pain and coffee-ground emesis for two days.Computed tomography(CT) scan of the abdomen andpelvis with contrast revealed segmental wall thickeningof the proximal jejunum with hyperdense, heterog-enous luminal content. Similar findings were evident inthe left lower small bowel region, suspicious for smallbowel hematoma and the possibility of intraluminalclots. Esophagogastroduodenoscopy performed postresuscitation showed punctate, erythematous lesionsthroughout the stomach as well as regions of smallbowel mucosa that appeared scalloped, ulcerated, andhemorrhaged on contact. Despite initial treatment for immunostain-positive focal cytomegalovirus gastritis, follow-up esophagogastroduodenoscopy after two months continued to demonstrate friable and irregular duodenal mucosa hinting at a different underlying etiol-ogy. Pathology reports from analyses of biopsy samples highlighted infiltration and expansion of the lamina pro-pria and submucosa. Subsequent staining with congo red/crystal violet and appropriate subtyping established the diagnosis of AL(kappa)-type amyloidosis. The sig-nificance of this case lies in the fact that our patient did not have the typically seen diagnostic systemic involvements-namely of heart and kidneys-usually seen in primary(AL) amyloidosis patients. It was the persis-tent endoscopic findings and biopsy results which gave clues to the physicians regarding the possibility of an abnormal protein-deposition entity. | Mohammad F Ali Anik Patel Stephanie Muller David Friedel | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 5 | Regulation of vascular calcification in atherosclerosis显示文摘 | Tintut Y Patel JK | 2001 | Z Kardiol2001，90，： | 1 |
| 6 | Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy显示文摘 | PATEL R NAGUEH S F TSYBOULEVA N | 2001 | Circulation2001，104，： | 1 |
| 7 | Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma irradiation and bleomycin is p53 independent显示文摘 | Patel V Ensley J F Gutkind J S | 2000 | Int J Cancer2000，88，5： | 1 |
| 8 | Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity显示文摘 | Patel H C Ross F M Heenan L E | 2006 | Journal of Neuroscience Research2006，83，3： | 1 |
| 9 | Reducing OWL entailment to description logic satisfiability显示文摘 | HORROCKS I PATEL SCHNEIDER P F | 2004 | Journal of Web Semantics2004，1，4： | 1 |
| 10 | Effect of IL-17A blockade with secukinumab in autoimmune diseases 显示文摘 | Patel DD Lee DM Kolbinger F | 2013 | Ann Rheum Dis2013，72，2： | 1 |
| 11 | Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice显示文摘 | Lacek K Vercauteren K Grzyb K Naddeo M Verhoye L Slowikowski M P Fafi-Kremer S Patel A H Baumert T F Folgori A Leroux-Roels G Cortese R Meuleman P Nicosia A | 2012 | J Hepatol2012，57，1： | 1 |
| 12 | Pelvic title and truncal inclination:two key radiographic parameters in the setting of adults with spinal deformity显示文摘 | Lafage V Schwab F Patel A | 2009 | Spine2009，34，17： | 1 |
| 13 | Alteration of NMDA NR1 receptors within the paraventricular nucleus of hypothala musin rats with heart failure显示文摘 | LI Y F CORNISH K G PATEL K P | 2003 | CircRes2003，93，10： | 1 |
| 14 | Earnings Management to Exceed Thresholds显示文摘 | Degeorge F Patel J Zeckhauser R | 1999 | Journal of Business1999，72，1： | 1 |
| 15 | In vitro activities of posaconazole,fluconazole,itraconazole,voriconazole,and amphotericin B against a large collection of clinical important molds and yeasts显示文摘 | Sabatelli F Patel R Mann P A | 2006 | Antimicrob Agents Chemother2006，50，6： | 1 |
| 16 | Chronic, sublethal nickel accli- mation alters the diffusive properties of renal brush border mem- brane vesicles (BBMVs) prepared from the freshwater rainbow trout 显示文摘 | Pane E F Patel M Wood C M | 2006 | Compara Biochem Physiol Part C2006，143，1： | 1 |
| 17 | Adult spinal deformity-postop- erative standing imbalance: how much can you tolerate? An over- view of key parameters in assessing alignment and planning correc- tive surgery 显示文摘 | Schwab F Patel A Ungar B | 2010 | Spine2010，35，25： | 1 |
| 18 | Eamings Manage- ment to Exceed Thresholds 显示文摘 | Degeorge F Patel J Zeckhauser R | 1999 | The Journal of Business1999，72，01： | 1 |
| 19 | Nano-engineered erythrocyte ghosts as inhalational carriers for delivery of fasudil: preparation and characterization显示文摘 | Gupta N Patel B Ahsan F | 2014 | Pharm Res2014，31，6： | 1 |
| 20 | Differential recognition of pitch patterns in discrete and gliding stimuli in congenital amusia:Evidence from Mandarin speakers显示文摘 | Liu F Xu Y Patel A D | 2012 | Brain and cognition2012，79，3： | 1 |
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