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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | Relation of family history of myocardial infarction and the presence of coronary arterial calcium in various age and risk factor groups显示文摘 | Philips B Lemos JA Patel MJ | | 0，，09： | 1 |
| 3 | Initial observations on the effect of irradiation on the liver-specific uptake of Levovist显示文摘 | Quaia E Blomley MJ Patel S | | 0，，： | 1 |
| 4 | Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2显示文摘 | Patel VA Dunn MJ Sorokin A | 2002 | Biol Chem2002，277，38： | 1 |
| 5 | Relation of family history of myocardial infarction and the presence of coronary arterial calcium in various age and risk factor groups显示文摘 | Philips B Lemos JA Patel MJ | 2007 | Am J Cardiol2007，99，6： | 1 |
| 6 | PARP inhibition: PARP1 and beyond 显示文摘 | Rouleau M Patel A Hendzel MJ | 2010 | Nat Rev Cancer2010，10，4： | 1 |
| 7 | Screening for heart disease:C-reactive protein versus coronary artery calcium显示文摘 | Patel AA Budoff MJ | 2010 | Expert Rev Cardiovasc Ther2010，8，1： | 1 |
| 8 | Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells显示文摘 | Parsons MJ Patel P Brat DJ | 2009 | Cancer Res2009，69，5： | 1 |
| 9 | PARPinhibition:PARPA1 and beyond 显示文摘 | ROULEAU M PATEL A HENDZEL MJ | 2010 | Nat Rev Cancer2010，10，4： | 1 |
| 10 | Lung transplantation for primary and secondary pulmonary hypertension显示文摘 | Conte JV Borja MJ Patel CB | 2001 | Ann Thorac Surg2001，72，： | 1 |
| 11 | Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2 显示文摘 | Patel VA Durra MJ Sorokin A | 2002 | J Biol Chem2002，277，38： | 1 |
| 12 | PARP inhibition:PARP1 and beyond 显示文摘 | Rouleau M Patel A Hendzcl MJ | 2010 | Nat Rev Cancer2010，10，： | 1 |
| 13 | Zinc and copper supplemen- tation are not cost-effective interventions in the treatment of acute diarrhea 显示文摘 | Patel AB Badhoniya N Dibley MJ | 2013 | J Clin Epidemiol2013，66，1： | 1 |
| 14 | A tool for rapid socioeco- nomic assessment 显示文摘 | Patel AB Prabhu AS Dibley MJ | 2007 | Indian J of Pediatrics2007，74，： | 1 |
| 15 | Brain metastases from prostate cancer: an ll-year analysis in the MRI era with emphasis on imaging characteristics, incidence, and prognosis显示文摘 | Hatzoglou V Patel GV Morris MJ | 2014 | J Neuroimaging2014，24，2： | 1 |
| 16 | Regulation of MDR - 1 ( P - glycoprorein) by cyclooxygenase-2 显示文摘 | Patel VA Dunn MJ Sorokin A | 2002 | J Biol Chem2002，277，38： | 1 |
| 17 | Phenobarbital alters hepatic MRP2 function by direct and indirect interactions显示文摘 | Patel NJ Zamek-Gliszczynski MJ | 2003 | Mol Pharmacol2003，64，1： | 1 |
| 18 | Regulation of MDR-1 (P- glycoprotein) by cyclooxygenase-2显示文摘 | Patel VA Dunn MJ Sorokin A | 2002 | J Biol Chem2002，277，38： | 1 |
| 19 | New symptomatic vertebral compression fractures within a year following vertebroplasty in osteoporotic women显示文摘 | Syed MJ Patel NA Jan S | 2005 | AJNR Am J Neuroradiol2005，26，： | 1 |
| 20 | Bronchial mucus transport velocity in patients receiving propofol and remifentanil versus sevoflurane and remifentanil anesthesia显示文摘 | Ledowski T Paech MJ Patel B | | 0，，05： | 1 |
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