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| 1 | Phytochemical analysis,hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats显示文摘Objective:To investigate the hepatoprotective and antioxidant activities of Alchornea cordifolia (A.cordifolia) leaf extract.Methods:Various solvent fractions of the methanol extract of the leaf of the plant.4.cordifolia Mull.Arg(Fam:Euphorbiaceae) were evaluated for hepatoprotective activity by carbon tetrachloride-induced liver damage in rats.The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase(SGOT/ AST),serum glutamate pyruvate transaminase(SCPT/ALT),alkaline phosphatase(ALP) and total bilirubin.The in vitro antioxidant activity of the extract was also evaluated by the I,I-diphenyl 2-picrylhydrazyl(DPPH) free radical scavenging assay.The extract was subjected to preliminary phytoehemical screening.Results:The ethyl acetate and chloroform fractions,at a dose of 300 mg/kg,produced significant(P<0.05) hepatoprolection by decreasing the activities of the serum enzymes and bilirubin while there were marked scavenging of the DPPH free radicals by the fractions.The effects were comparable to those of the standard drugs used for the respective experiments,silymarin and ascorbic acid.Alkaloids,flavonoids,saponins and tannins were delected in the phylochemical screening.Conclusion:From this study,it was concluded that the plant of A.cordifolia possesses hepatoprotective as well as antioxidant activities and these activities reside mainly in the ethyl acetate and acetone fractions of methanol leaf extract. | Patience O Osadebe Festus BC Okoye Philip F Uzor Nneka R Nnamani Ijeoma E Adiele Nkemakonam C Obiano | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 2 | Assessment of weed species composition and species diversity in some fruit orchards显示文摘 | Patience O Stephen T Olawale A | 2013 | Albanian Journal of Agricultural Sciences2013，12，2： | 1 |
| 3 | Adolescent risk behavior and the influence of parents and education显示文摘 | Nelson B V Patience T H Mac Donald D O | 1999 | Journal of the American Board of Family Medicine1999，12，： | 1 |
| 4 | Marked prolongation of porcine renal xenograft survival in baboons through the use of α-1, 3 galactosyltransferase gene-knock out donors and the cotransplantation of vascularized thymic tissue显示文摘 | Yamada K Yazawa K Shimizu A Iwanaga T Hisashi Y Nuhn M O'Malley P Nobori S Vagefi P A Patience C Fisherman J Cooper D K C Hawley R J Greenstein J Schuurman H-J Awwad M Sykes M Sachs D H | 2005 | Nature Medicine2005，11，1： | 1 |
| 5 | Antimotility effects of extracts and fractions of Eastern Nigeria mistletoe(Loranthus micranthus Linn)显示文摘Objective:To evaluate the antimotility activity of Eastern Nigerian mistletoe[Loranthus micranthus(L.micranthus) Linn]parasitic on six different host trees viz.Baphia nitida,Persia americana,Kola accuminata,Irvingia gabonensis,Citrus simensis and Pentacletra macrophylla (P.mycrophylla).Methods:The antimotility of the methanol extracts and solvent fractions were evaluated in castor oil induced diarrheoa in rats.Results:The methanol extracts(200 mg/kg, i.p.) inhibited defeacation significantly(P < 0.05) 4 h after administration(75.73%to 93.33%) more than that of atropine sulphate(2 mg/kg,i.p.) which inhibited defeacation by 80.0%.The methanol extract(200 mg/kg,i.p.) of L micranthus parasitic on P.mycrophylla exhibited significant(P<0.05) inhibition in gastrointestinal transit(67.6%) more than that of atropine sulphate(2 mg/kg,Lp.) which inhibited gastrointestinal transit by 26.4%.The solvent fractions of L micranthus parasitic on P.mycrophylla at dose levels of 150 mg/kg inhibited significantly the gastrointestinal transit of mice.Fraction F5 exhibited inhibitory activity which was comparable to loperamide(73.3%). Conclusions:The methanol extract of L micranthus parasitic on P.macrophylla exhibits higher antimotility activity that other extracts.The solvent fractions could serve as source of novel antimotility agents. | Patience O Osadebe Chika C Abba Matthias O Agbo | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 0 |
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