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| 1 | Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis显示文摘AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations(variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality(OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites(OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed. | Jonathan G Stine Puja M Shah Scott L Cornella Sean R Rudnick Marwan S Ghabril George J Stukenborg Patrick G Northup | 2015 | World Journal of Hepatology2015，7，27： | 42 |
| 2 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 3 | Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis显示文摘AIM To examine if liver transplant recipients with high-risk non-alcoholic steatohepatitis(NASH) are at increased risk for pre-transplant portal venous thrombosis.METHODS Data on all liver transplants in the United States from February 2002 through September 2014 were analyzed. Recipients were sorted into three distinct groups: High-risk(age > 60, body mass index > 30 kg/m2, hypertension and diabetes), low-risk and non-NASH cirrhosis. Multivariable logistic regression models were constructed.RESULTS Thirty-five thousand and seventy-two candidates underwent liver transplantation and of those organ recipients, 465 were transplanted for high-risk and 2775 for lowrisk NASH. Two thousand six hundred and twentysix(7.5%) recipients had pre-transplant portal vein thrombosis; 66(14.2%) of the high-risk NASH group had portal vein thrombosis vs 328(11.8%) of the lowrisk NASH group. In general, all NASH recipients were less likely to be male or African American and more likely to be obese. In adjusted multivariable regression analyses, high-risk recipients had the greatest risk ofpre-transplant portal vein thrombosis with OR = 2.11(95%CI: 1.60-2.76, P < 0.001) when referenced to the non-NASH group.CONCLUSION Liver transplant candidates with high-risk NASH are at the greatest risk for portal vein thrombosis development prior to transplantation. These candidates may benefit from interventions to decrease their likelihood of clot formation and resultant downstream hepatic decompensating events. Prospective study is needed. | Jonathan G Stine Curtis K Argo Shawn J Pelletier Daniel G Maluf Stephen H Caldwell Patrick G Northup | 2017 | World Journal of Hepatology2017，9，3： | 2 |
| 4 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 5 | Review of rapid diagnostic tests for influenza 显示文摘 | Patrick J G Richard BT Jr | 2003 | Clinical and applied immunology reviews2003，4，： | 1 |
| 6 | Formanilide and carbanilide from aniline and carbon dioxide 显示文摘 | Munshi Pradip Heldebrant David J McKoon Erin P Kelly Patrick A Tai Chih-Cheng Jessop Philip G | 2003 | Tetrahedron Letters2003，44，： | 1 |
| 7 | Hybrid fiber Bragg grating/long period fiber grating sensor for strain/temperature discrimination显示文摘 | Patrick H J Williams G M Kersey A D | 1996 | IEEE Photon Technol Lett1996，8，： | 1 |
| 8 | 查看详情显示文摘 | Schuch R Garibian A Nygaard P Raymond S Araik G Hans H S Patrick J P Per N | | 0，，： | 1 |
| 9 | Interleukin-8 signaling attenuates TRAIL-and chemotherapyinduced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells显示文摘 | Catherine W Timothy W Patrick G J | 2008 | Mol Cancer Ther2008，7，9： | 1 |
| 10 | Fiber grating sensors 显示文摘 | A D Kersey M A Davis H J Patrick M LeBlanc K P Koo C G Askins M A Putnam E J Friebele | 1997 | Lightwave Technology1997，15，8： | 1 |
| 11 | Fenton-driven chemical regeneration of MTBE-spent GAC显示文摘 | Scott G H Patrick K J Wendell P E | 2005 | Water Research2005，39，10： | 1 |
| 12 | Oxidation of Roading Asphalts 显示文摘 | Herrington P R Patrick J E Ball G F A | 1994 | IndEngChemRes1994，33，11： | 1 |
| 13 | Metabolic engineering of sugars and simple sugar derivatives in plants显示文摘 | Patrick J W Botha F C Birch R G | 2013 | Plant Biotechnology Journal2013，11，2： | 1 |
| 14 | The kinetics of the hydriding of uranium metal显示文摘 | POWELL G L HARPER W L KIRK- PATRICK J R | 1991 | J Less-Common Met1991，，： | 1 |
| 15 | The reduction of silica carbon and silicon carbide 显示文摘 | Patrick D M Lee J G Ivan B C | 1979 | J Am Ceram Soc1979，62，34： | 1 |
| 16 | The Nucleus 22-channel cochlear implant system显示文摘 | Patrick J F Clark G M | 1991 | Ear Hear1991，12，4： | 1 |
| 17 | Multiple independent emer- gences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria显示文摘 | Burns C C Shaw J Jorba J Bukbuk D Adu F Gumede N Pate M A Abanida E A Gasasira A Iber J Chen Q Vincent A Chenoweth P Henderson E Wannemuehler K Naeem A Umarni R N Nishimura Y Shimizu H Baba M Adeniji A Williams A J Kil- patrick D R Oberste M S Wassilak S G Tomori O Pallansch M A Kew O | 2013 | J Virol2013，87，9： | 1 |
| 18 | A simple enantioselective preparation of (2S,5S) -2,5-diphenylpyrrolidine and related diaryl amines显示文摘 | William M Duttona Patrick G Stee | 2000 | Tetrahedron:Asymmetry2000，11，： | 1 |
| 19 | Urinary type Ⅱ collagen ttelieal peptide ( HELIX - Ⅱ) as a new biochemical marker of cartilage degradation in patients with osteoarthritis and rheumatoid arthritis显示文摘 | Nadine C Fabrice J Patrick G | 2005 | Arthritis Rheum2005，52，： | 1 |
| 20 | A short synthesis of (±) -epiasarinin 显示文摘 | David J A Anne J D Patrick G S | 2002 | Organic Letters2002，7，4： | 1 |
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