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| 1 | Side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: Influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC显示文摘AIM: To investigate the systemic availability of budesonide in a patient with Child A drrhosis due to autoimmune hepatitis (AIH) and primary hepatocellular carcinoma, who developed serious side effects.METHODS: Serum levels of budesonide, 6β-OH-budesonide and 16α-OH-prednisolon were measured by HPLC/MS/MS;portosysternic shunt-index (SI) was determined by 99mTc nuclear imaging. All values were compared with a matched control patient without side effects.RESULTS: Serum levels of budesonide were 13-fold increased in the index patient. The ratio between serum levels of the metabolites 6β-OH-budesonide and 16α-OH-prednisolone, respectively, and serum levels of budesonide was diminished (1.0 vs. 4.0 for 6β-OH-budesonide, 4.2 vs.10.7 for 16α-OH-prednisolone). Both patients had portosystemic SI (5.7% and 3.1%) within the range of healthy subjects.CONCLUSION: Serum levels of budesonide vary up to 13-fold in AIH patients with Child A cirrhosis in the absence of relevant portosysternic shunting. Reduced hepatic metabolism, as indicated by reduced metabolite-to-drug ratio, rather than portosystemic shunting may explain systemic side effects of this drug in cirrhosis. | Andreas Geier Carsten Gartung Christoph G.Dietrich Hermann E.Wasmuth Patrick Reinartz Siegfried Matern | 2003 | World Journal of Gastroenterology2003，9，12： | 3 |
| 2 | FDG—a marker of tumour hypoxia? A comparison with [18F]fluoromisonidazole and pO2-polarography in metastatic head and neck cancer显示文摘 | Michael Zimny Bernd Gagel Ercole DiMartino Kurt Hamacher Heinz H. Coenen Martin Westhofen Michael Eble Ulrich Buell Patrick Reinartz | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，12： | 1 |
| 3 | pO2 Polarography Versus Positron Emission Tomography ([18F] Fluoromisonidazole, [18F]-2-Fluoro-2’-Deoxyglucose)显示文摘 | Bernd Gagel MD Patrick Reinartz Ercole DiMartino Michael Zimny Michael Pinkawa Payam Maneschi Sven Stanzel Kurt Hamacher Heinz H. Coenen Michael Westhofen Ulrich Büll Michael J. Eble | 2004 | Strahlentherapie und Onkologie2004，，10： | 1 |
| 4 | Benign versus malignant osseous lesions in the lumbar vertebrae: differentiation by means of bone SPET显示文摘 | Patrick Reinartz Joachim Schaffeldt Osama Sabri Michael Zimny Bernd Nowak Elisabeth Ostwald Uwe Cremerius Udalrich Buell | 2000 | European Journal of Nuclear Medicine2000，，6： | 1 |
| 5 | Side-by-side reading of PET and CT scans in oncology: which patients might profit from integrated PET/CT?显示文摘 | Patrick Reinartz Franz-Josef Wieres Wolfram Schneider Alexander Schur Ulrich Buell | 2004 | European Journal of Nuclear Medicine and Molecular Imaging2004，，11： | 1 |
| 6 | Fatty acid binding receptors in intestinal physiology and pathophysiology显示文摘Free fatty acids are essential dietary components and recognized as important molecules in the maintenance of cellular homeostasis.In the last decade,the molecular pathways for free fatty acid sensing in the gastrointestinal tract have been further elucidated by molecular identification and functional characterization of fatty acid binding receptors.These sensing molecules belong to the family of G proteincoupled receptors.In the intestine,four important receptors have been described so far.They differ in molecular structure,ligand specificity,expression pattern,and functional properties.In this review,an overview of intestinal fatty acid binding receptors and their role in intestinal physiology and pathophysiology is given. | Elke Kaemmerer Patrick Plum Christina Klaus Ralf Weiskirchen Christian Liedtke Maximilian Adolf Angela Schippers Norbert Wagner Andrea Reinartz Nikolaus Gassler | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，5： | 0 |
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