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| 1 | Hepatitis C virus genotypes distribution and transmission risk factors in Luxembourg from 1991 to 2006显示文摘AIM:To analyze the Hepatitis C virus (HCV) genotype distribution and transmission risk factors in a population of unselected patients in Luxembourg. METHODS:Epidemiological information (gender, age and transmission risks) were collected from 802 patients newly diagnosed for hepatitis C and living in Luxembourg, among whom 228 patients referred from prison. Genotyping using 5'noncoding (5'NC) sequencing was performed. We compared categorical data using the Fisher's exact F-test and odds ratios (OR) were calculated for evaluating association of HCV genotype and risk factors. RESULTS:The sex ratio was predominantly male (2.2) and individuals aged less than 40 years represented 49.6% of the population. Genotype 1 was predominant (53.4%) followed by genotype 3 (33%). Among risk factors, intravenous drug usage (IVDU) was the most frequently reported (71.4%) followed by medical-related transmission (17.6%) including haemophilia, transfusion recipients and other nosocomial reasons. Genotype 3 was significantly associated to IVDU (OR = 4.84, P < 0.0001) whereas genotype 1 was significantly associated with a medical procedure (OR = 2.42, P < 0.001). The HCV genotype distribution from inmate patients differed significantly from the rest of the population (Chi-square test with four degrees of freedom, P < 0.0001) with a higher frequency of genotype 3 (46.5% vs 27.5%) and a lower frequency of genotype 1 and 4 (44.7% vs 56.8% and 5.3% vs 9.6%, respectively). IVDU was nearly exclusively reported as a risk factor in prison. CONCLUSION:We report the first description of the HCV genotype distribution in Luxembourg. The repartition is similar to other European countries, with one of the highest European prevalence rates of genotype 3 (33%). Since serology screening became available in 1991, IVDU remains the most common way of HCV transmission in Luxembourg. | Francois Roman Karin Hawotte Daniel Struck Anne-Marie Ternes Jean-Yves Servais Vic Arendt Patrick Hoffman Robert Hemmer Thérèse Staub Carole Seguin-Devaux Jean-Claude Schmit | 2008 | World Journal of Gastroenterology2008，14，8： | 3 |
| 2 | Quality of life of persons urinary incontinence:development of a new measure显示文摘 | Wagner TH Patrick DL Bavendam TG | 1996 | Urology1996，47，1： | 1 |
| 3 | The many faces of the publish/subscribe 显示文摘 | Patrick TH Eugster Pascal A Felber Rachid Guerraoui | 2003 | ACM Computer Surveys2003，35，2： | 1 |
| 4 | The many faces of publish/subscribe显示文摘 | Eugster Patrick Th Felber P Guerraoui R | 2003 | ACM Computing Surveys2003，35，2： | 1 |
| 5 | Quality of life of persons with urinary incontinence: Development of a new measure显示文摘 | Wagner TH Patrick DL Bavendam TG | 1996 | Urolo gy1996，47，1： | 1 |
| 6 | Quality of life in persons with urinary incontinence: Development of a new measure显示文摘 | Wagner TH Patrick DL Bavendam TG | 1996 | Urology1996，47，1： | 1 |
| 7 | Quality of life of person with urinary, incontinence : development of a new measure 显示文摘 | Wagner TH Patrick DL Bavendam TG | 1996 | Urology1996，47，1： | 1 |
| 8 | Determination of volatile organic compounds in marine biota 显示文摘 | Patrick Roose Udo A Th Brinkman | 1998 | J Chromatogr A1998，799，： | 1 |
| 9 | Quality of life of persons with urinary incontinence: development of a new measure显示文摘 | Wagner TH Patrick DL Bavendam TG | 1996 | Urology1996，47，1： | 1 |
| 10 | Quality of life of persons with urinary incontinence: development of a new measure显示文摘 | Wagner TH Patrick DL Bavendam TG | 1996 | Urology1996，47，1： | 1 |
| 11 | The many faces of publish/subscribe显示文摘 | Patrick Th Eugster Pascal A Felber Rachid Guerraoui | 2003 | ACM Computing Surveys2003，35，2： | 1 |
| 12 | Isolation and x-ray crystal structure of (E)-4-(r-1\',t-2\',c-4\'-Trihydroxy-2\',6\',6\'-trimethylcyclohexyl)but-3-en-2-one, a constituent of new zealand thyme honey 显示文摘 | Seng TT Alistair LW Patrick TH | 1989 | Aust J Chem1989，42，： | 1 |
| 13 | BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells显示文摘 | Meike Haddad-Weber Patrick Prager Manuela Kunz Lothar Seefried Franz Jakob Martha M. Murray Christopher H. Evans Ulrich N? th Andre F. Steinert | 2010 | Cytotherapy2010，，4： | 1 |
| 14 | The many faces of pub-lish/subscribe显示文摘 | Patrick Th Eugster Pascal A Felber | 2003 | ACM Computing Surveys2003，35，2： | 1 |
| 15 | Quality of life in persons with urinary incontinence:Development of a new measure 显示文摘 | Wagner TH Patrick DL Bavendam TG | 1996 | Urolo- gy1996，47，1： | 1 |
| 16 | The many faces of publish/subscribe 显示文摘 | Patrick TH Eugster Pascal A Felber RachidGuerraoui | 2003 | ACM Compu tingSurveys2003，35，2： | 1 |
| 17 | The many faces of publish/subscribe显示文摘 | Patrick Th Eugster Pascal A Felber Rachid Guerraoui Anne Marie Kermarrec | 2003 | ACM Computing Surveys2003，2，： | 1 |
| 18 | Quality of life of persons with urinary incontinence : development of a new measure显示文摘 | Wagner TH Patrick DL Bavendam TG | 1996 | Urology1996，47，1： | 1 |
| 19 | Quality of life of persons with urinary incontinence: Development of a new measure 显示文摘 | Wagner TH Patrick DL Bavendam TG | 1996 | Urology1996，47，： | 1 |
| 20 | Interfacial Reinitiation of Free Radicals Enables the Regeneration of Broken Polymeric Hydrogel Actuators显示文摘Living organisms,from plants to animals,have inspired and guided the design and fabrication of polymeric hydrogels with biomimetic morphology,shape deformation,and actuation behavior.However,the existing polymeric hydrogels are fragile and vulnerable,which seriously hinders further application.Therefore,endowing hydrogels with a biomimetic self-growth property and regenerating the macroscopic shape of hydrogels after they suffer significant damage are highly desirable for the next generation of adaptive biomimetic hydrogels.Inspired by the tail regeneration of geckos,we herein report an efficient and universal strategy of interfacial diffusion polymerization(IDP),which can regenerate the polymeric layer at a solid–liquid interface,thereby growing new hydrogels on the existing hydrogel layers.Through changing the solvent viscosity and/or monomer type of the hydrogel precursor,diverse new hydrogels have been regenerated to endow the initial hydrogels with additional fluorescent functions and/or actuating properties.Due to the high efficiency and universality of IDP,an injured hydrogel actuator can be repaired,regenerated,and recovered to its initial condition,even after suffering severe damage such as cutting or piercing.We believe that the regeneration strategy of polymeric hydrogels will inspire the design of biomimetic materials and motivate the fabrication of the next generation of soft robots with adaptive and multifunctional properties. | Baoyi Wu Huanhuan Lu Yukun Jian Dachuan Zhang Yu Peng Jie Zhuo Xiaoxia Le Jiawei Zhang Patrick Théato Tao Chen | 2023 | CCS Chemistry2023，5，3： | 0 |
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