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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | Final contractor se- lection using the analytical hierarchy process 显示文摘 | PATRICK S W F SONIA K Y C | 2000 | Construction Management and Economics2000，18，5： | 1 |
| 4 | Image understanding for iris biometrics:a survey 显示文摘 | Kevin W B Karen H Patrick J F | 2008 | Computer Vision and Image Understanding2008，110，2： | 1 |
| 5 | The B73 maize genome: complexity, diversity, and dynamics显示文摘 | Patrick S S Doreen W Robert S F | 2009 | Science2009，326，： | 1 |
| 6 | Phosphorus budget and management strategies for an urban Wisconsin lake 显示文摘 | James William F Barko John W Eakin Harry L Sorge Patrick W | 2002 | Lake&ReservoirManagement2002，18，2： | 1 |
| 7 | Costs and returns ofeducation in five agricultural regions of eastern Brazil显示文摘 | KEHRBERG E W | 1973 | American Journal of Agricultural Economics1973，，55： | 1 |
| 8 | Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial显示文摘 | Edward J Gane Stuart K Roberts Catherine AM Stedman Peter W Angus Brett Ritchie Rob Elston David Ipe Peter N Morcos Linda Baher Isabel Najera Tom Chu Uri Lopatin M Michelle Berrey William Bradford Mark Laughlin Nancy S Shulman Patrick F Smith | 2010 | The Lancet2010，，9751： | 1 |
| 9 | Metabolic engineering of sugars and simple sugar derivatives in plants显示文摘 | Patrick J W Botha F C Birch R G | 2013 | Plant Biotechnology Journal2013，11，2： | 1 |
| 10 | Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual显示文摘 | S.Eva Singletary Craig Allred Pandora Ashley Lawrence W Bassett Donald Berry Kirby I Bland Patrick I Borgen Gary M Clark Stephen B Edge Daniel F Hayes Lorie L Hughes Robert V.P Hutter Monica Morrow David L Page Abram Recht Richard L Theriault Ann Thor Don | 2003 | Surgical Clinics of North America2003，，4： | 1 |
| 11 | Ef- fect of diet on infant subcutaneous tissue fatty acids 显示文摘 | FAEQUHAKSON J COCKBURN F PATRICK W A | 1993 | Archives of Disease in Childhood1993，69，： | 1 |
| 12 | Analysis of reactive oxygen species generating systems in rat epididymal spermatozoa显示文摘 | Patrick V Norma F Ceanna W | 2006 | Biol Reprod2006，65，： | 1 |
| 13 | Sources of and Responses to Risk:Factor Analyses of Large-scale US Combelt Farmers显示文摘 | Musser W N | 1997 | Manaholt Studies1997，，7： | 1 |
| 14 | Sources of and Responses to Risk: Factor Analyses of Large-scale US Cornbeh Farmers 显示文摘 | Patrick G F Musser W N | 1997 | Manshoh Studies1997，7，： | 1 |
| 15 | Label-free optical detection of peptide synthesis on a porous silicon scaffold/Sensor显示文摘 | Patrick F Caiyan L Nicholas W | 2008 | Langmuir2008，24，6： | 1 |
| 16 | Killer DNA plasmids of the Yeast Kluyveromyces lactis显示文摘 | Micheline W Patrick D Hiroshi F | 1982 | Curr Genet1982，5，3： | 1 |
| 17 | The B73 maize genome : Complexity, diversity, and dynamics 显示文摘 | Patrick S S Doreen W Robert S F | 2009 | Science2009，326，： | 1 |
| 18 | KIH-485 and S-Metolachlor Efficacy Comparisons in Conventional and No- Tillage Cornl 显示文摘 | PATRICK W G PHILLIP W S JOHN C F | 2006 | Weed Technology2006，20，3： | 1 |
| 19 | Nicotine Stroop and addiction memory-an ERP study 显示文摘 | Thorsten F Patrick W Manfred H | 2006 | International Journal of Psychophysiology2006，62，2： | 1 |
| 20 | Nicotine stroop and addiction memory: An ERP study 显示文摘 | Thorsten F Patrick W Manfred H | 2006 | International Journal ofPsychophysiology2006，62，2： | 1 |
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