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| 1 | Three-dimensional analysis of the physiological foramen geometry of maxillary and mandibular molars by means of micro-CT显示文摘The aim of this study was to investigate the physiological foramen diameter, shape and distance between physiological and anatomical apex of maxillary and mandibular first and second molars. Accurate knowledge of the physiological foramina morphology; thus, inherent mechanical shaping technical hindrances, is decisive when taking the corresponding root canal final preparation decision. The morphological dimensions of a total of 1 727 physiological foramina were investigated by means of micro-computed tomography. Mean narrow and wide(to a high number, oval) diameters of the physiological foramen were 0.24,0.22 and 0.33 mm and 0.33, 0.31 and 0.42 mm in mesiobuccal(MB), distobuccal(DB) and palatal(P) roots in maxillary first molars; 0.24, 0.22 and 0.33 mm and 0.41, 0.33 and 0.44 in MB, DB, and P roots in maxillary second molars. Mandibular first molars showed mean narrow and wide diameters of 0.24 and 0.30 mm and of 0.39 and 0.46 mm in mesial(M) and distal(D)roots; second mandibular molars showed 0.25 and 0.31 mm and 0.47 mm in M and D roots. The mean distance between the physiological foramina and anatomical apex was 0.82, 0.81 and 1.02 mm and 0.54, 0.43 and 0.63 mm in MB, DB and P roots of the maxillary first and second molars, respectively. A mean distance of 0.95 mm(M) and 1.05 mm(D) in the first and0.78 mm(M) and 0.81 mm(D) in the second mandibular molars was observed. Based on the results obtained, assumable recommendations for final preparation size of the physiological foramen were calculated. However, when taking into consideration, the resulting standard deviations of marginal errors must be cautiously considered when taking a final decision in clinical endodontic treatment. | Thomas Gerhard Wolf Frank Paqué Michael Sven Patyna Brita Willershausen Benjamín Briseno-Marroquín | 2017 | International Journal of Oral Science2017，9，3： | 4 |
| 2 | SU14813 : a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity 显示文摘 | PATYNA S LAIRD A D MENDEL D B | 2006 | Mol Cancer Ther2006，5，7： | 1 |
| 3 | A proposed multigeneration protocol for Japanese medaka(Oryzias latipes ) to evaluate effects of en- docrine disruptQrs显示文摘 | Patyna P J Davi R A Parkerton T F | 1999 | The Science of the Total Environment1999，233，13： | 1 |
| 4 | Evaluation of the safety and pharmacokinetics of the multi-targeted receptor tyrosine kinase inhibitor sunitinib during embryo-fetaldevelopment in rats and rabbits 显示文摘 | Patyna S Haznedar J Morris D | 2009 | Birth Defects Res B Dev Reprod Toxicol2009，86，4： | 1 |
| 5 | Hazard evaluation of anddiisodecyl phthalate and diisodecyl phthalate in a Japanesemedaka mnhigenerational assay 显示文摘 | Patyna P J Brown R P Davi R A | 2006 | Ecotoxicol Environ Saf2006，65，1： | 1 |
| 6 | A proposed multigeneration protocol for Japanese medaka (Oryzias latipes) to evaluate effects of endocrine disruptors 显示文摘 | Patyna PJ Davi RA Parkerton TF | 1999 | Sci Total Environ1999，233，13： | 1 |
| 7 | Phase II Study of Sunitinib in Patients with Non-small Cell Lung Cancer and Irradiated Brain Metastases显示文摘 | Silvia Novello Carlos Camps Francesco Grossi Julien Mazieres Lauren Abrey Jean-Marc Vernejoux Aron Thall Shem Patyna Tiziana Usari Zhixiao Wang Richard C. Chao Giorgio Scagliotti | 2011 | Journal of Thoracic Oncology2011，，7： | 1 |
| 8 | A proposed muhigeneration protocol for Japanese medaka ( Oryzias latipes) to evalu- ate effects of endocrine disruptors显示文摘 | PATYNA P J DAVI R A PARKERTON T F | 1999 | Science of the Total Environment1999，233，123： | 1 |
| 9 | Hazard evaluation of diisononyl phthalate and diisodecyl phthalate in a Japanese medaka multigenerational assay 显示文摘 | Patyna PJ Brown RP Davi RA | 2006 | Ecology and Environmental Safety2006，65，： | 1 |
| 10 | SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity显示文摘 | PATYNA S LAIRD AD MENDEL DB | 2006 | Mol Cancer Ther2006，5，7： | 1 |
| 11 | SU14813:a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity 显示文摘 | PATYNA S LAIRD AD MENDEL DB | 2006 | Mol Cancer Ther2006，5，7： | 1 |
| 12 | Single- and multiple- dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species 显示文摘 | Haznedar JO Patyna S Bello CL | 2009 | Cancer Chemother Pharmacol2009，64，4： | 1 |
| 13 | SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity 显示文摘 | Patyna S Laird AD Mendel DB | 2006 | Mol Cancer Ther2006，5，7： | 1 |
| 14 | SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity 显示文摘 | Patyna S Laird AD Mendel DB | 2006 | Mol Cancer Ther2006，5，7： | 1 |
| 15 | A proposed multigeneration protocol for Japanese medaka (Oryzias latipes) to evaluate effects of endocrine disrupters 显示文摘 | Patyna PJ Davi RA Parkerton TF | 1999 | Sci Total Environ1999，233，3： | 1 |
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