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| 1 | The immunobiology of avian systemic salmonellosis显示文摘 | Lucy Chappell Peter Kaiser Paul Barrow Michael A. Jones Claire Johnston Paul Wigley | 2008 | Veterinary Immunology and Immunopathology2008，，1： | 1 |
| 2 | Salmonella carrier state in chicken: comparison of expression of immune response genes between susceptible and resistant animals显示文摘 | Jean-Rémy Sadeyen Jér?me Trotereau Philippe Velge José Marly Catherine Beaumont Paul A. Barrow Nat Bumstead Anne-Christine Lalmanach | 2004 | Microbes and Infection2004，，14： | 1 |
| 3 | Virulence determinants of Salmonella Gallinarum biovar Pullorum identified by PCR signature-tagged mutagenesis and the spiC mutant as a candidate live attenuated vaccine显示文摘 | Shizhong Geng Xinan Jiao Paul Barrow Zhiming Pan Xiang Chen | 2013 | Veterinary Microbiology2013，，： | 1 |
| 4 | Multi-attribute partitioning of power networks based on electrical distance显示文摘 | Cotilla-Sanchez Eduardo Hines Paul DH Barrows Clayton | 1992 | IEEE Transactions on Power Systems1992，7，2： | 1 |
| 5 | Resistance to Salmonellosis in the Chicken is linked to NRAMP1 and TNC显示文摘 | JINXIN HU NAT BUMSTEAD PAUL BARROW | 1997 | Genome Research1997，7，7： | 1 |
| 6 | In vivo and in vitro studies of genetic resistance to systemic salmonellosis in the chicken encoded by the SAL1 locus显示文摘 | Paul Wigley Scott D. Hulme Nat Bumstead Paul A. Barrow | 2002 | Microbes and Infection2002，，11： | 1 |
| 7 | Genome degradation promotes Salmonella pathoadaptation by remodeling fimbriae-mediated proinflammatory response显示文摘Understanding changes in pathogen behavior(e.g.increased virulence,a shift in transmission channel)is critical for the public health management of emerging infectious diseases.Genome degradation via gene depletion or inactivation is recognized as a pathoadaptive feature of the pathogen evolving with the host.However,little is known about the exact role of genome degradation in affecting pathogenic behavior,and the underlying molecular detail has yet to be examined.Using large-scale global avian-restricted Salmonella genomes spanning more than a century,we projected the genetic diversity of Salmonella Pullorum(bvSP)by showing increasingly antimicrobial-resistant ST92 prevalent in Chinese flocks.The phylogenomic analysis identified three lineages in bvSP,with an enhancement of virulence in the two recently emerged lineages(L2/L3),as evidenced in chicken and embryo infection assays.Notably,the ancestor L1 lineage resembles the Salmonella serovars with higher metabolic flexibilities and more robust environmental tolerance,indicating stepwise evolutionary trajectories towards avian-restricted lineages.Pan-genome analysis pinpointed fimbrial degradation from a virulent lineage.The later engineeredfim-deletion mutant,and all other five fimbrial systems,revealed behavior switching that restricted horizontal fecal-oral transmission but boosted virulence in chicks.By depleting fimbrial appendages,bvSP established persistent replication with less proinflammation in chick macrophages and adopted vertical transovarial transmission,accompanied by ever-increasing intensification in the poultry industry.Together,we uncovered a previously unseen paradigm for remodeling bacterial surface appendages that supplements virulence-enhanced evolution with increased vertical transmission. | Xiao Zhou Xiamei Kang Jiaqi Chen Yan Song Chenghao Jia Lin Teng Yanting Tang Zhijie Jiang Xianqi Peng Xiaoxi Tao Yiwei Xu Linlin Huang Xuebin Xu Yaohui Xu Tengfei Zhang Shenye Yu Jiansen Gong Shaohui Wang Yuqing Liu Guoqiang Zhu Corinna Kehrenberg Franois-Xavier Weill Paul Barrow Yan Li Guoping Zhao Min Yue | 2023 | National Science Review2023，10，10： | 0 |
| 8 | 接种沙门氏菌苗可使新生雏鸡和强制换羽母鸡得到免疫保护显示文摘过去人们常认为,由于刚出壳雏鸡的免疫系统尚未发育成熟,同时肠道内缺乏有益的微生物,因而处于高度的敏感期,此时接种沙门氏菌苗产生的保护作用很有限。然而,最新的研究表明,在这些敏感期接种疫苗,可诱发产生保护作用。 | 胡宇 Filip Van Immerseel Paul Barrow Peter Holt Ulrich Methner Richard Ducatelle | 2007 | 国外畜牧学(猪与禽)2007，，2： | 0 |
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