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12篇 您的检索式:作者名="Paul GL"
    题名 作者 年代 出处 被引量
1Permissive hypercapnia-role in protective lung ventilatory strategies显示文摘John GL Donall OC Paul M 2004Intensive Care Med2004,30,:1
2Effect of biomass concentration and mycelial morphology on fermentation broth rheology显示文摘Riley GL Tucker K G Paul GC 2000Biotechnol Bioeng2000,68,2:1
3Cerebral microvascular pathology in aging and Alzheimer's disease显示文摘Eszter F Paul GL 2001Prog Neurobiol2001,64,6:1
4Prompt Gamma Activation Analysis Using the ko Approach显示文摘Molnar GL Revay Z Paul RL 1998J Radioanal Nucl Chem1998,234,12:1
5Serum and urinary markers of skeletal muscle tissue damage after weight lifting exercise显示文摘Paul GL 1989Appl Physiol1989,,58:1
6Dietary protein requirements of physically active individuals显示文摘Paul GL 1989Sports Med1989,8,3:1
7The rationale for consuming protein blends in sports nutrition显示文摘Paul GL 2009J Am Coil Nutr2009,28,:1
8Effect of biomass concentration and mycelial morphology on fermentation broth rheology显示文摘Riley GL Tucker KG Paul GC 0,,2:1
9Rellability of isometric and isokinetic evaluations of ankle dorsi/plantar strength among older adults 显示文摘Paul GL 1997Isokinetics and Exercise Science1997,4,:1
10Histidine availability alters glucagon gene expression in murine alpha TC6 cells显示文摘Paul GL Waegner A Gaskins HR 1998J Nutr1998,128,6:1
11Serum and urinary mark- ers of skeletal muscle tissue damage after weight lifting exercise 显示文摘Paul GL DeLany JP Snook JT 1989Eur J Appl Physiol Occup Physiol1989,58,7:1
12CXCR5^(+)PD-1^(++)CD4^(+)T cells colonize infant intestines early in life and promote B cell maturation显示文摘Gastrointestinal infections are a major cause for serious clinical complications in infants.The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++CD4+T cells(TFH cells).We investigated the ontogeny of CXCR5+PD-1++CD4+T cells in human intestines.While CXCR5+PD-1++CD4+T cells were absent in fetal intestines,CXCR5+PD-1++CD4+T cells increased after birth and were abundant in infant intestines,resulting in significant higher numbers compared to adults.These findings were supported by scRNAseq analyses,showing increased frequencies of CD4+T cells with a TFH gene signature in infant intestines compared to blood.Co-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B cells.Taken together,we demonstrate that functional TFH cells are numerous in infant intestines,making them a promising target for oral pediatric vaccine strategies.Ana Jordan-Paiz Glòria Martrus Fenja L.Steinert Max Kaufmann Adrian F.Sagebiel Renée R.C.E.Schreurs Anne Rechtien Martin E.Baumdick Johannes M.Jung Kimberly J.Möller Lucy Wegner Cordula Grüttner Laura Richert Roland Thünauer Jennifer Schroeder-Schwarz Johannes Bvan Goudoever Teunis B.H.Geijtenbeek Marcus Altfeld Steven T.Pals Daniel Perez Paul L.Klarenbeek Christian Tomuschat Guido Sauter Ingo Königs Udo Schumacher Manuel A.Friese Nathaniel Melling Konrad Reinshagen Madeleine J.Bunders 2023Cellular & Molecular Immunology2023,20,2:0
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