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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 4 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | 轮胎工业用更安全的操作油显示文摘在欧洲 ,立法和公众压力正在使欧洲市场上的操作油性质发生变化。这引起欧洲橡胶行业对不使用有潜在致癌危险芳香油的新型轮胎和橡胶配方进行评述。本文对这一状况进行了研究 ,并探讨了美国市场上可能出现的动态 ,介绍了不同产品的需求量以及北美操作油和润滑基油制造不断变化的局面。 | Paul W H T Juergen E P 吴淑华 | 2002 | 轮胎工业2002，22，5： | 3 |
| 5 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 2 |
| 6 | Plant volatiles as a defense against insect herbivores 显示文摘 | PAUL W P JAMES H T | 1999 | Plant Physiology1999，121，： | 1 |
| 7 | Polymer matrix degradation and color or formation in melt processed nylon6 /clay nanocomposites显示文摘 | Fornes T D Yoon P J Paul D R | 2003 | Polymer2003，44，24： | 1 |
| 8 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 9 | Visible-light-mediated TiOz photocatalysis of fluoroquinolone antibacterial agents 显示文摘 | Paul T Miller P L Strathmann T J | 2007 | Environment Science and Technology2007，41，： | 1 |
| 10 | Rheological behavior of multi- walled carbon nanotube/polycarbonate composites 显示文摘 | Potschke P Fornes T D Paul D R | 2002 | Polymer2002，43，11： | 1 |
| 11 | Radiofrequency catheter ablation in small children : relationship of complications to application dose 显示文摘 | Blaufox A D Paul T Saul J P | 2004 | Pacing Clin Electrophysiol2004，27，2： | 1 |
| 12 | SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo显示文摘 | Paul J D Coulombe K L Toth P T | 2013 | J Mol Cell Cardiol2013，64，： | 1 |
| 13 | Rheological Beha- viour of Multiwalled Carbon Nanotubes/Polycarbonate Composites显示文摘 | Potschke P Fornes T D Paul D R | 2002 | Polymer2002，43，11： | 1 |
| 14 | Kidney transplantation after oxygenated machine perfusion preservation with Custodiol-Nsolution显示文摘 | Minor T Paul A Efferz P | 2015 | Transpl Int2015，28，9： | 1 |
| 15 | Carbon materials obtained from organo metallic modification of pitch and its oxidation resistance prop erties显示文摘 | Paul P P Schwab S T | | 0，，01： | 1 |
| 16 | Transgenie production of a variant of human tissue-type plasminogen aetivator in goat milk: generation of transgenie goats and analysis of expression 显示文摘 | Ebert K M Selgrath J P Paul D T | 1991 | Bio Teehnol1991，9，： | 1 |
| 17 | OTU deu- biquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis 显示文摘 | TYCHO E T M MANUELA K H PAUL P G | 2013 | Cell2013，154，： | 1 |
| 18 | Evidence based Diagnosis and Staging of Pancreatic Cancer 显示文摘 | Michl P Pauls S Gress T M | 2006 | Best Pract Res Clin Gast roenterol2006，20，2： | 1 |
| 19 | Rheological behavior of multiwalled carbon nanotube/polycarbonate composites显示文摘 | Potschke P Fornes T D Paul D R | 2002 | Polymer2002，43，： | 1 |
| 20 | Nylon 6nanocomposites:the effect of matrix molecular weight显示文摘 | Fornes T D Yoon P J Keskkula H Paul D R | 2001 | Polymer2001，42，： | 1 |
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