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| 1 | Observation of environment-Induced double sudden transitions in geometric quantum correlations显示文摘 | Paula F M Silva I A Montealegre J D | 2013 | Phys Rev Lett2013，111，25： | 1 |
| 2 | Absence of cross-reactivity to myeloperoxidase of anti-thyroid microsomal antibodies in patients with autoimmune thyroid diseases显示文摘 | Freire B A Paula I D Paula F | 2001 | Am J Med Sci2001，321，2： | 1 |
| 3 | Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting显示文摘 | DE PAULA D M V L B R I | 2007 | RNA2007，13，： | 1 |
| 4 | University-industry collaboration and innovation in emer- gent and mature industries in new industrialized coun- tries显示文摘 | Freitas I M B Marques R A De Paula Silva D E | 2013 | Research Policy2013，42，2： | 1 |
| 5 | Specialized Neuromuscular Training to Improve Neuromuscular Function and Biomechanics in a Patient With Quiescent Juvenile Rheumatoid Arthritis显示文摘 | Gregory D Myer Hermine I Brunner Paula G Melson | 2005 | Physical Therapy2005，85，8： | 1 |
| 6 | Sesquiterpenes, triterpenoids, limonoids and flavonoids of Cedrela odorata graft and speculations on the induced resistance against Hypsipyla grandella显示文摘 | Paula J D Vieira I J C Silva M F | 1997 | Phytochemistry1997，44，8： | 1 |
| 7 | Potential environmental effects of probiotics used in aquaculture显示文摘 | Diego I Paula D Maria T M | 2012 | Aquaculture International2012，20，： | 1 |
| 8 | Polymer nanotechnology of' nano - composites 显示文摘 | PAULA D R ROBESONB I M | 2008 | Polymer2008，49，15： | 1 |
| 9 | 添加大豆饲料对奶牛生产性能、消化和代谢的影响显示文摘研究高浓缩甘蔗饲料中添加不同浓度的大豆油(SBO)对奶牛的牛奶质量和代谢反应的影响。试验选取8头泌乳中期(体重574±19.1 kg,产奶122±6.9 d),平均产奶量22.5±1.22 kg·d^(-1),随机分配到4×4拉丁方阵中。试验为期21 d,包括前14 d适应期,15~21 d采样期。根据SBO占干物质(DM)的比例不同,分为空白组(0%)、低剂量组(1.57%)、中剂量组(4.43%)和高剂量组(7.34%)。随着SBO的添加,干物质摄入量呈二次方趋势降低。中剂量组和高剂量组干物质摄入量最低。牛奶和能量校正乳产量均受SBO添加的影响,但中剂量组轻微减少,而高剂量组大幅下降。乳脂浓度呈线性下降,空白组含量为3.78%,而高剂量组为3.50%。高剂量组瘤胃中潜在的可消化中性洗涤纤维消化率从55.7%下降至35.2%,瘤胃中的可消化中性洗涤纤维部分消化率速度呈直线下降到1.39%·h^(-1),而空白组为3.13%·h^(-1)。从高剂量组可知,瘤胃中的中性洗涤纤维消化率受影响较大,为2.25%·h^(-1)。空白组和高剂量组瘤胃pH从6.42升到6.67,氨氮从28.1下降到21.4 mg·dL^(-1)。中剂量组和高剂量组瘤胃挥发性脂肪酸含量下降,血清葡萄糖、脂肪酸和β-羟丁酸不受SBO影响。然而,随着SBO的添加,血清中总胆固醇、高密度脂肪和低密度脂蛋白浓度线性增加。SBO添加量从4.43%到7.34%过程中,干物质采食量、能量校正乳产量、纤维消化率和瘤胃发酵程度均下降,因此在奶牛饲料中添加SBO 1.57%是安全的。 | Rodrigues J P P Paula R M d Rennó L N Fontes M M S Machado A F Filho S d C V Huhtanen P Marcondes M I | 2017 | 饲料博览2017，0，8： | 0 |
| 10 | Impact of preoperative antibiotics and other variables on integrated microbiome-host transcriptomic data generated from colorectal cancer resections显示文摘BACKGROUND Integrative multi-omic approaches have been increasingly applied to discovery and functional studies of complex human diseases.Short-term preoperative antibiotics have been adopted to reduce site infections in colorectal cancer(CRC)resections.We hypothesize that the antibiotics will impact analysis of multi-omic datasets generated from resection samples to investigate biological CRC risk factors.AIM To assess the impact of preoperative antibiotics and other variables on integrated microbiome and human transcriptomic data generated from archived CRC resection samples.METHODS Genomic DNA(gDNA)and RNA were extracted from prospectively collected 51 pairs of frozen sporadic CRC tumor and adjacent non-tumor mucosal samples from 50 CRC patients archived at a single medical center from 2010-2020.The 16S rRNA gene sequencing(V3V4 region,paired end,300 bp)and confirmatory quantitative polymerase chain reaction(qPCR)assays were conducted on gDNA.RNA sequencing(IPE,125 bp)was performed on parallel tumor and non-tumor RNA samples with RNA Integrity Numbers scores≥6.RESULTS PERMANOVA detected significant effects of tumor vs nontumor histology(P=0.002)and antibiotics(P=0.001)on microbialβ-diversity,but CRC tumor location(left vs right),diabetes mellitus vs not diabetic and Black/African Ancestry(AA)vs not Black/AA,did not reach significance.Linear mixed models detected significant tumor vs nontumor histology*antibiotics interaction terms for 14 genus level taxa.QPCR confirmed increased Fusobacterium abundance in tumor vs nontumor groups,and detected significantly reduced bacterial load in the(+)antibiotics group.Principal coordinate analysis of the transcriptomic data showed a clear separation between tumor and nontumor samples.Differentially expressed genes obtained from separate analyses of tumor and nontumor samples,are presented for the antibiotics,CRC location,diabetes and Black/AA race groups.CONCLUSION Recent adoption of additional preoperative antibiotics as standard of care,has a measurable impact on-omics analysis of resected specimens.This study still confirmed increased Fusobacterium nucleatum in tumor. | Sarah A Malik Chencan Zhu Jinyu Li Joseph F LaComb Paula I Denoya Igor Kravets Joshua D Miller Jie Yang Melissa Kramer W Richard McCombie Charles E Robertson Daniel N Frank Ellen Li | 2021 | World Journal of Gastroenterology2021，27，14： | 0 |
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