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| 1 | 陕南石笋稳定同位素记录中的古气候和古季风信息显示文摘采自陕西省柞水县的石笋给出了过去 750a来的高分辨率气候记录以及全新世和80~ 330ka之间的低分辨率的气候变化。定年方法使用了石笋生长纹层计数法、2 10 Pb法和TIMS2 30 Th法。分析了石笋中δ18O和δ13C的气候含义 ,认为当δ18O和δ13C值变重时 ,指示干热的气候组合 ,当δ18O和δ13C值同时变轻时 ,指示湿冷的气候组合。在长时间尺度δ18O值的变化以反映温度变化为主 ,δ13C值的变化反映湿度变化为主。当δ18O变轻 ,而δ13C变重时 ,指示干冷气候。这时期的夏季风很弱而冬季风很强 ,相反 ,当δ18O变重 ,而δ13C变轻时 ,指示湿热气候 ,表明夏季风很强 ,冬季风很弱。过去 750a的记录中分为 :公元 12 50~ 152 0年的温暖中世纪 (MedievalWarmPeriod) ,公元 152 0~ 182 0年的湿冷小冰期 (LittleIceAge)和公元 182 0年以来的温热期。全新世的气候在 4 0 0 0a左右有一显著的变化。在此时之前的温度低于全新世的平均气温 ,而在此之后的温度高于全新世的平均气温。全新世气候记录可细分为 18个不同的时期。 | 李红春 顾德隆 Dorte Paulsen 王非 陈文寄 尹功明 程海 R.L.Edwards | 2000 | 地震地质2000，22，B12： | 26 |
| 2 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 3 | Effects of insulin and pathway inhibitors on the PI3K-Akt- mTOR phosphorylation profile in acute myeloid leukemia cells显示文摘The phosphatidylinositol 3-kinase(PI3K)-Akt-mechanistic target of rapamycin(mTOR)pathway is constitutively activated in human acute myeloid leukemia(AML)cells and is regarded as a possible therapeutic target.Insulin is an agonist of this pathway and a growth factor for AML cells.We characterized the effect of insulin on the phosphorylation of 10 mediators in the main track of the PI3K-Akt-mTOR pathway in AML cells from 76 consecutive patients.The overall results showed that insulin significantly increased the phosphorylation of all investigated mediators.However,insulin effects on the pathway activation profile varied among patients,and increased phosphorylation in all mediators was observed only in a minority of patients;in other patients,insulin had divergent effects.Global gene expression profiling and proteomic/phosphoproteomic comparisons suggested that AML cells from these two patient subsets differed with regard to AML cell differentiation,transcriptional regulation,RNA metabolism,and cellular metabolism.Strong insulin-induced phosphorylation was associated with weakened antiproliferative effects of metabolic inhibitors.PI3K,Akt,and mTOR inhibitors also caused divergent effects on the overall pathway phosphorylation profile in the presence of insulin,although PI3K and Akt inhibition caused a general reduction in Akt pT308 and 4EBP1 pT36/pT45 phosphorylation.For Akt inhibition,the phosphorylation of upstream mediators was generally increased or unaltered.In contrast,mTOR inhibition reduced mTOR pS2448 and S6 pS244 phosphorylation but increased Akt pT308 phosphorylation.In conclusion,the effects of both insulin and PI3K-Akt-mTOR inhibitors differ between AML patient subsets,and differences in insulin responsiveness are associated with differential susceptibility to metabolic targeting. | Ina Nepstad Kimberley Joanne Hatfield Ida Sofie Grønningsæter Elise Aasebø Maria Hernandez-Valladares Karen Marie Hagen Kristin Paulsen Rye Frode SBerven Frode Selheim Håkon Reikvam Øystein Bruserud | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 4 | 使用Trufill DCS Orbit^(TM)水解脱铂金圈治疗颅内动脉瘤中期随访结果显示文摘 | Rick Paulsen MD | 2005 | 介入放射学杂志2005，14，6： | 3 |
| 5 | 铝电解中二氧化锡基(氢气)气体阳极(英文)显示文摘开发一种在低温电解质(850°C)铝电解中应用的新型二氧化锡基气体阳极以降低铝电解能耗和二氧化碳排放。在此种气体阳极中,氢气通入阳极后参与阳极反应,分别用石墨和铝作阴极和参比电极。采用循环伏安法研究此体系中铂和二氧化锡基电极上氧离子的电化学行为,并确定氧气的析出电势。然后,采用气体电极进行恒电流电解实验,相对于未通入气体和通入氩气,通入氢气后阳极出现明显的去极化现象(阳极电势约下降0.8 V)。实验结果表明,氢气已参与阳极三相界面(气体-电解质-电极)反应,为还原性气体阳极在铝电解上的应用提供了可行性。 | 肖赛君 Tommy MOKKELBOST Ove PAULSEN Arne P.RATVIK Geir M.HAARBERG | 2014 | Transactions of Nonferrous Metals Society of China2014，24，12： | 2 |
| 6 | Nitro-PAH exposures of occupationally-exposed traffic workers and associated urinary 1-nitropyrene metabolite concentrations显示文摘The assessment of occupational exposure to diesel exhaust(DE) is important from an epidemiological perspective. Urinary biomarkers of exposure have been proposed as a novel approach for measuring exposure to DE. In this study, we measured the concentrations of two urinary metabolites of 1-nitropyrene(1NP), a nitrated polycyclic aromatic hydrocarbon that has been suggested as a molecular marker of diesel particulate matter. These two metabolites, 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were determined in urine samples(10 m L) from a small group of workers who were occupationally-exposed to vehicle exhaust in Trujillo, Peru, before and after their workshifts. Workshift exposures to1 NP, as well as PM_(2.5), 2-nitropyrene and 2-nitrofluoranthene, were also measured.Exposures to 1NP were similar in all studied workers, averaging 105 ± 57.9 pg/m^3(±standard deviation). Median urinary concentrations of the average of the pre- and post-exposure samples for 6-hydroxy-1-nitropyrene and 8-hydroxy-1-nitropyrene, were found to be 3.9 and 2.3 pg metabolite/mg creatinine, respectively in the group of occupationally-exposed subjects(n = 17) studied. A direct relationship between workshift exposure to 1NP and urinary 1NP metabolites concentrations was not observed. However,the 1NP exposures and the creatinine-corrected urinary concentrations of the hydroxynitropyrene metabolites in these Peruvian traffic workers were similar to occupationally-exposed taxi drivers in Shenyang, China, and were higher than biomarker levels in office workers from Trujillo without occupational exposure to vehicle exhaust.This study provides further evidence that urinary metabolites of 1NP are associated with exposure to DE and may serve as a useful exposure biomarker. | Justin P.Miller-Schulze Michael Paulsen Takayuki Kameda Akira Toriba Kazuichi Hayakawa Brandon Cassidy Luke Naeher Manuel Aguilar Villalobos Christopher D.Simpson | 2016 | Journal of Environmental Sciences2016，28，11： | 2 |
| 7 | Brassica rapa plants adapted to microgravity with reduced photosystem I and its photochemical activity显示文摘 | E Hilaire A Q Paulsen | 2004 | Physiologia plantarum2004，122，2： | 1 |
| 8 | Optimal choice of dividend barriers for a risk process with stochastic return of investment 显示文摘 | Paulsen J Gjessing H | 1997 | Insurance: Mathematics and Economics1997，20，： | 1 |
| 9 | Ruin theory with compounding assets: a survey显示文摘 | Paulsen J | 1998 | Insurance Mathematics and Economics1998，22，： | 1 |
| 10 | Studies of the Layered Manganese Bronzes, Na2/3 O2 with M = Co, Ni, Li and Li2/2 O2 Prepared by Ion-exchange 显示文摘 | J M Paulsen J R Dahn | 1999 | Solid State Ionics1999，126，1： | 1 |
| 11 | Illumination for computer vision systems显示文摘 | Paulsen MR McClure WF | 1986 | Trans of the ASAE1986，29，5： | 1 |
| 12 | Stewart Extractable starch as a quality measurement of dried corn显示文摘 | Paulsen M R Mbuvi S W Haken A E | 2002 | Applied Engineering in Agriculture2002，19，2： | 1 |
| 13 | Pulp and perio- dontal healing, root development and root resorption subsequent to transplantation anc显示文摘 | Paulsen HU Andreasen JO Schwartz O | 1995 | Am J Orthod Dentofacial Orthop1995，108，6： | 1 |
| 14 | Novel Lithium-Ion Cathode Ma- terials Based on Layered Manganese Oxides 显示文摘 | Ammundsen B Paulsen J | 2001 | Adv Mater2001，13，： | 1 |
| 15 | TLR-2-mediated induction of vascular endothelial growth factor (VEGF) in cartilage in septic joint disease显示文摘 | VAROGA D PAULSEN F MENTLEIN R | 2006 | J Pathol2006，210，3： | 1 |
| 16 | Resveratrol has inhibitory effects on the hypoxia-induced inflammation and angiogenesis in human adipose tissue in vitro显示文摘 | Cullberg KB Olholm J Paulsen SK | 2013 | Eur J Pharm Sci2013，49，2： | 1 |
| 17 | Proton dependent mul- tidrug efflux systems显示文摘 | Paulsen I T Brown M H Skurray R A | 1996 | Microbiol Rev1996，60，4： | 1 |
| 18 | EMAP-surface water:a multi-assemblage probability survey of ecological integrity in the USA显示文摘 | Hughes R M Paulsen S G Stoddard J L | 2000 | Hydrobiologia2000，422，4： | 1 |
| 19 | Leukocyte rheolojy in recent stroke显示文摘 | Emst E Matrai h Paulsen F | 1987 | Stroke1987，18，1： | 1 |
| 20 | An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism:the use of fluorocitrate显示文摘 | Paulsen R E Contestabile A Villani L | 1987 | J Neurochem1987，48，5： | 1 |
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