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1Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19.Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral 2021Cellular & Molecular Immunology2021,18,9:2
2Effect of substrate concentration on dry mesophilic anaerobic digestion of organic fraction of municipal solid waste (OFMSW) 显示文摘Ferna'ndez J Pe'rez M Romero L I 2008Bioresource Technology2008,99,14:1
3First detection of canine parvovirus type 2c in South America 显示文摘Pe'rez R Francia L Romero V 2007Vet Microbiol2007,124,12:1
4Toughening by nanostructure显示文摘Ruiz -Pe'rez L Royston G J Fairclough J P A 2008Polymer2008,49,21:1
5Bacillusthuringiensis subsp, israelensis CytlAa synergizes CryllAa toxin by functioning as a membrane-bound receptor显示文摘Pe'rez C Ferna'ndez L E Sun J 2005Proceeding of the National Academy of Sciences2005,102,18:1
6Simpson– G olabi– B ehmel Syndrome Type 1 and Hepatoblastoma in a Patient With a Novel Exon 2–4 Duplication of the GPC 3 Gene显示文摘María Elena Mateos Katrin Beyer Eduardo López‐Laso Juan López Siles Juan Luis Pérez‐Navero María José Pe?a Juana Guzmán Juliana Matas 2013Am J Med Genet2013,,5:1
7Organosolv Pulping of Wheat Straw by Use of Phenol 显示文摘Jimenez L dela Torre M J Maestre F Ferrer J L Pe'rez I 1997Bioresour Technol1997,60,3:1
8Fermentation optimization for the production of lovastatin by Aspergillus terreus : Use of the response surface methodology 显示文摘Casas Lo'pez J L Sa'nchez Pe'rez J A Ferna'ndez Sevilla J M 2004J Chem Technol Biotechnol2004,79,:1
9Thermophilic anaerobic digestion of source-sorted organic fraction of municipal solid waste显示文摘FORSTER CARNEIRO T PE’REZ M ROMERO L I 2008Bioresource Technology2008,99,:1
10Activity of a new antipseudomonal cephalosporin, CXA-I01, against car- bapenem- resistant and multidrug- resistant显示文摘Juan C Zamorano L Pe'rez JL 2010Antimicrob Ag Chemther2010,54,2:1
11Organizational learning as a determining factor in business performance显示文摘Susana Pérez López José Manuel Montes Peón Camilo José Vazquez Ordás 2005The Learning Organization2005,,3:1
12Role of the chemokines RANTES, monocyte chemotactic proteins- 3 and -4, and eotaxins- 1 and -2 in childhood asthma 显示文摘Rojas -Ramos E Avalos AF Pe'rez - Fernandez L 2003Eur Respir J2003,22,5:1
13Transesterification of sunflower oil over zeolites using different metal loading:A case of leaching and agglomeration studies显示文摘RAMOS M J CASAS A RODRIGUEZ L ROMERO R PE'REZ A 2008Appl Catal A2008,346,12:1
14Hemolytic uremic syndrome with mild renal involvement due to Shigatoxin-producing Escherichia coli(STEC)O145 strain显示文摘Pe rez L Apeztegui a L Pineyru a C 2014Rev Argent Microbio2014,46,2:1
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