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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | cDNA and deduced amino acid sequences of a peritrophic membrane glycoprotein,'peritrophin-48',from the larvae of Lucilia cuprina显示文摘 | Schorderet S Pearson R D Vuocolo T | 1998 | Insect Biochemistry and Molecular Biology1998，28，： | 1 |
| 5 | Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients 显示文摘 | Lamont J M McManamy C S Pearson A D | 2004 | Clin Cancer Res2004，10，： | 1 |
| 6 | Critical pathways as a strategy for improving care:Problems and potential显示文摘 | Pearson S D Goulart-Fisher D Lee T H | 1995 | Annals of internal medicine1995，123，12： | 1 |
| 7 | Video-rate image correlation processor显示文摘 | Pearson J J Hines D C Golosman S | | 0，，： | 1 |
| 8 | Potentiation of VSV N J infection in mice by mosquito salive显示文摘 | Limesand K H Higgs S Pearson L D | 2000 | Parascte Immunol2000，22，9： | 1 |
| 9 | Solvent extraction/anion exchange separation and determination of PGEs(Os,Ir,Pt,Pd,Ru)and Re-Os isotopes in geological samples by isotope dilution ICP-MS显示文摘 | Pearson D G Woodland S J | | 0，，1： | 1 |
| 10 | Concentration-dependent effects of 9-cisretinoic acid on neuroblastoma differentiation and proliferation in vitro显示文摘 | Lovat P E Lsmis S P Pearson A D | 1994 | Neurosci Lett1994，182，1： | 1 |
| 11 | Critical pathways as a strategy for improving care:problems and potential显示文摘 | Pearson S D Goulan-Fisher D Lee TH | 1995 | Ann Intern Med1995，125，5： | 1 |
| 12 | A new silicon p-n junction photocell for converting solar radiation into electri-cal power 显示文摘 | Chapin D M Fuller C S Pearson G L | 1954 | J Appl Phys1954，25，5： | 1 |
| 13 | On the existence and role of free radicals in methanol conversion to hydrocarbons over HZSM-5 I: inhibition by NO显示文摘 | Chang C D Hellring S D Pearson J A | 1989 | J Catal1989，115，： | 1 |
| 14 | Critical Pathways Intervention to Reduce Length of Hospital Stay显示文摘 | Pearson S D Kleefield S F Soukop J R | 2001 | Am J Med2001，110，10： | 1 |
| 15 | Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha:haploinsufficiency is associated with reduced serum apolipoprotein M levels显示文摘 | RICHTER S SHIH D Q PEARSON E | 2003 | Diabetes2003，52，： | 1 |
| 16 | Biological and ecological insights into Ca isotopes in planktic foraminifers as a palaeotemperature proxy显示文摘 | Kasemann S A Schmidt D N Pearson P N | 2008 | Earth Planetary Sciences Letters2008，271，14： | 1 |
| 17 | Multimetric macroinvertebrate indices for mid-continent US great rivers显示文摘 | Angradi T R Pearson M S Bolgrien D W | 2009 | Journal of the North American Benthological Society2009，28，4： | 1 |
| 18 | Re-Os, Sm-Nd, and Rb-Sr Isotope Evidence for Thick Archaean Lithospherie Mantle Beneath the Siberian Craton Modi- fied by Multistage Metasomatism显示文摘 | PEARSON D SHIREY S CARLSON R | 1995 | Geochimica et Cos- moehimica Acta1995，59，5： | 1 |
| 19 | Air-water exchange and mass balance of toxaphene in the Great Lakes 显示文摘 | Swackhamer D Schottler S Pearson R | 1999 | Environ Sci Technol1999，33，21： | 1 |
| 20 | The role of AP-1 in glucocortieoid resistance in leukaemia显示文摘 | BAILEY S HALL A G PEARSON A D J | 2001 | Leukemia2001，15，： | 1 |
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