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1篇 您的检索式:作者名="Pei Lin Chee"
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1The Thermogel Chronicle——From Rational Design of Thermogelling Copolymers to Advanced Thermogel Applications显示文摘CONSPECTUS:Temperature responsive supramolecular hydrogels,also known as thermogels,are produced by the self-assembly of amphiphilic copolymers in solution following temperature stimulus.They are a class of high caliber novel materials possessing highly attractive properties such as injectability,ability to undergo temperature controlled reversible sol−gel phase transitions,high biocompatibility,and tunable biodegradability.Much research vigor has been dedicated to designing advanced amphiphilic copolymers and investigating their molecular interactions in order to enhance the properties of the thermogelling systems and expand the scope of their applications.As such,thermogelling systems have since become well established in the field of sustained localized drug or protein delivery and have also been demonstrated as high potential materials for niche applications such as threedimensional cell culture,wound healing patches,and vitreous endotamponades.Recent developments saw the advent of thermogelling systems with advanced biomedical applications ranging from enhanced cancer therapy to radiology imaging to tissue engineering,and these are usually achieved by the conjugating of biologically relevant molecules such as drugs and peptides to the thermogel copolymer or by incorporating nanoparticles into the thermogel systems.New developments in this field see a shift away from employing traditional synthetic polymers such as polypropylene glycol(PPG)and poly(lactic-co-glycolic acid)(PLGA)to utilizing more advanced nature-derived bioactive molecules and also introducing chiral moieties in the thermogelling copolymer backbone.Qianyu Lin Cally Owh Jason Y.C.Lim Pei Lin Chee Michelle P.Y.Yew Eilis T.Y.Hor Xian Jun Loh 2021Accounts of Materials Research2021,2,10:1
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