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| 1 | Technology-Driven and Evidence-Based Genomic Analysis for Integrated Pediatric and Prenatal Genetics Evaluation显示文摘The first decade since the completion of the Human Genome Project has been marked with rapid development of genomic technologies and their immediate clinical applications.Genomic analysis using oligonucleotide array comparative genomic hybridization(aCGH) or single nucleotide polymorphism(SNP) chips has been applied to pediatric patients with developmental and intellectual disabilities(DD/ ID),multiple congenital anomalies(MCA) and autistic spectrum disorders(ASD).Evaluation of analytical and clinical validities of aCGH showed>99%sensitivity and specificity and increased analytical resolution by higher density probe coverage.Reviews of case series, multi-center comparison and large patient-control studies demonstrated a diagnostic yield of 12%—20%;approximately 60%of these abnormalities were recurrent genomic disorders.This pediatric experience has been extended toward prenatal diagnosis.A series of reports indicated approximately 10%of pregnancies with ultrasound-detected structural anomalies and normal cytogenetic findings had genomic abnormalities,and 30%of these abnormalities were syndromic genomic disorders.Evidence-based practice guidelines and standards for implementing genomic analysis and web-delivered knowledge resources for interpreting genomic findings have been established.The progress from this technology-driven and evidence-based genomic analysis provides not only opportunities to dissect disease-causing mechanisms and develop rational therapeutic interventions but also important lessons for integrating genomic sequencing into pediatric and prenatal genetic evaluation. | Yuan Wei Fang Xu Peining Li | 2013 | Journal of Genetics and Genomics2013，40，1： | 4 |
| 2 | Cgr1,a ripe rot resistance QTL in Vitis amurensis‘Shuang Hong’grapevine显示文摘Ripe rot is a serious grapevine disease in Vitis L.and Muscadinia(Planch.)Small.However,resistance to this disease has been reported in some oriental Vitis species.To identify resistance-related Quantitative Trait Loci(QTLs)from the Chinese grape species V.amurensis,an F1 population of V.vinifera‘Cabernet Sauvignon’×V.amurensis‘Shuang Hong’was used to map the ripe rot resistance loci expected in‘Shuang Hong’grape.A total of 7598 single nucleotide polymorphisms(SNPs)between the parents were identified in our previous study,and 934 SNPs were selected for genetic map construction.These SNPs are distributed across the 19 chromosomes covering a total of 1665.31 cM in length,with an average of 1.81 cM between markers.Ripe rot resistance phenotypes among the hybrids were evaluated in vitro using excised leaves for three consecutive years from 2016 to 2018;a continuous variation was found among the F1 hybrids,and the Pearson correlation coefficients of the phenotypes scored in all three years were significant at the 0.01 level.Notably,the first QTL reported for resistance to grape ripe rot disease,named Cgr1,was identified on chromosome 14 of‘Shuang Hong’grapevine.Cgr1 could explain up to 19.90%of the phenotypic variance.In addition,a SNP named‘np19345’was identified as a molecular marker closely linked to the peak of Cgr1 and has the potential to be developed as a marker for the Cgr1 resistance haplotype. | Peining Fu Quanyou Tian Gongti Lai Rongfang Li Shiren Song Jiang Lu | 2019 | Horticulture Research2019，6，1： | 3 |
| 3 | Spectrum of Cytogenomic Abnormalities Revealed by Array Comparative Genomic Hybridization on Products of Conception Culture Failure and Normal Karyotype Samples显示文摘Approximately 30% of pregnancies after implantation end up in spontaneous abortions, and 50% of them are caused by chromosomal abnormalities. However, the spectrum of genomic copy number variants(CNVs) in products of conception(POC) and the underlying genedosage-sensitive mechanisms causing spontaneous abortions remain largely unknown. In this study, array comparative genomic hybridization(a CGH) analysis was performed as a salvage procedure for 128 POC culture failure(POC-CF) samples and as a supplemental procedure for106 POC normal karyotype(POC-NK) samples. Chromosomal abnormalities were detected in 10% of POC-CF and pathogenic CNVs were detected in 3.9% of POC-CF and 5.7% of POC-NK samples. Compiled results from this study and relevant case series through a literature review demonstrated an abnormality detection rate(ADR) of 35% for chromosomal abnormalities in POC-CF samples, 3.7% for pathogenic CNVs in POC-CF samples, and 4.6% for pathogenic CNVs in POC-NK samples. Ingenuity Pathway Analysis(IPA) was performed on the genes from pathogenic CNVs found in POC samples. The denoted primary gene networks suggested that apoptosis and cell proliferation pathways are involved in miscarriage. In summary, a similar spectrum of cytogenomic abnormalities was observed in POC culture success and POC-CF samples. A threshold effect correlating the number of dosage-sensitive genes in a chromosome with the observed frequency of autosomal trisomy is proposed. A rationalized approach using firstly fluorescence in situ hybridization(FISH) testing with probes of chromosomes X/Y/18, 13/21, and 15/16/22 for common aneuploidies and polyploidies and secondly a CGH for other cytogenomic abnormalities is recommended for POC-CF samples. | Qinghua Zhou Shen-Yin Wu Katherine Amato Autumn DiAdamo Peining Li | 2016 | Journal of Genetics and Genomics2016，43，3： | 3 |
| 4 | Effects of boron number per unit volume on the shielding properties of composites made with boron ores from China显示文摘The total macroscopic removal cross sections,deposited energies and the absorbed doses of three new shielding composites loaded with specific boron-rich slag,boron concentrate ore and boron mud of China for 252Cf neutron source were investigated by experimental and Monte Carlo calculation.The results were evaluated by boron mole numbers per unit volume in composites.The half value layers of the composites were calculated and compared with that of Portland concrete,indicating that ascending boron mole numbers per unit volume in the composites can enhance the shielding properties of the composites for 252Cf neutron source. | LI Zhefu XUE Xiangxin LIU Sulan LI Yong DUAN Peining | 2012 | Nuclear Science and Techniques2012，23，6： | 2 |
| 5 | Anisotropic polaritons in van der Waals materials显示文摘Polaritons in two-dimensional(2D)materials continues to garner significant attention due to their favorable ability of field-confinement and intriguing potential for low-loss and ultrafast optical and photonic devices.The recent experimental observation of in-plane anisotropic dispersion in natural van der Waals materials has revealed much richer physics as compared to isotropic plasmonic materials,which provides new insight to manipulate the polaritons and manufacture flat optical devices with unprecedented controls.Herein,we give an overview of the recent progress in in-plane anisotropic polaritons launched and visualized in the near-field range in 2D layered van der Waals materials.Furthermore,future prospects in this promising but emerging field are featured on the basis of its peculiar applications.This review article will stimulate the scientific community to explore other hyperbolic materials and structures in order to develop optical technologies with novel functionalities and further improve the understanding of the exotic photonic phenomena. | Weiliang Ma Babar Shabbir Qingdong Ou Yemin Dong Huanyang Chen Peining Li Xinliang Zhang Yuerui Lu Qiaoliang Bao | 2020 | InfoMat2020，2，5： | 2 |
| 6 | Study on hydro-forming technology of manufacturing bimetallic CRA-lined pipe显示文摘 | Xuesheng Wang Peining Li Ruzhu Wang | 2005 | Interna- tional Journal of Machine Tools & Manufacture 45 (2005):373- 3782005，45，2005： | 1 |
| 7 | Controlled synthesis of BLOCl hierarchical self-assemblies with highly efficient photocatalytic properties 显示文摘 | Peng Shengjie Li Linlin Zhu peining | 2013 | Chemistry - An A- sian Journal2013，8，1： | 1 |
| 8 | Study onHydro-forming Hechnology of Manufacturing Bimetallic CRA-lined pipe显示文摘 | W ANG Xuesheng LI Peining WANG Ruzhu | 2005 | International Journal of Machines Tools & Manufacture2005，，45： | 1 |
| 9 | Study on hydro-forming technology of manufacturing bimetallic CRA-lined pipe显示文摘 | Wang Xuesheng Li Peining Wang Ruzhu | | 0，，4： | 1 |
| 10 | Age Trends and Correlations of Fiber Traits in Clone of Eucalyptus Urophylla×E.Grandis in Guangdong Province显示文摘Growth traits and wood properties were assessed for DH32-29,a clone of Eucalyptus urophylla×E.grandis,at the age of two to six in Guangdong,China.Analysis of variance of studied traits showed that there were significant differences(1%level)on Fiber Length and Fiber Width among ages,with F value ranging from 12.73 to 18.91,indicating clear differences between ages.The Fiber Length increased from 0.58 mm at 2-year to 0.60 mm at 3-year,061 mm at 4-year,0.72 mm at 5-year and 0.79 mm at 6-year,meanwhile the annual Fiber Length increment among ages increased from 0.02 to 0.01,0.11 and 0.07 mm,respectively.However,Mean Curl,Kink Index and Kink Angle were not found any trend by age.In general,the correlations between same traits were different with different ages.The biggest negative correlations(-0.78)was found between Fiber Length and Fine Percentage at 4-year while the biggest positive correlations(0.98)was found between Kink Index and Kink Angle at 2-year and 4-year. | Shijun Wu Jianmin Xu Guangyou Li Peining Song Wenzhong Gu | 2017 | 环境科学前沿(中英文版)2017，6，1： | 1 |
| 11 | Boron nitride nanoresonators for phonon-enhanced molecular vibrational spectroscopy at the strong coupling limit显示文摘Enhanced light-matter interactions are the basis of surface-enhanced infrared absorption(SEIRA)spectroscopy,and conventionally rely on plasmonic materials and their capability to focus light to nanoscale spot sizes.Phonon polariton nanoresonators made of polar crystals could represent an interesting alternative,since they exhibit large quality factors,which go far beyond those of their plasmonic counterparts.The recent emergence of van der Waals crystals enables the fabrication of highquality nanophotonic resonators based on phonon polaritons,as reported for the prototypical infrared-phononic material hexagonal boron nitride(h-BN).In this work we use,for the first time,phonon-polariton-resonant h-BN ribbons for SEIRA spectroscopy of small amounts of organic molecules in Fourier transform infrared spectroscopy.Strikingly,the interaction between phonon polaritons and molecular vibrations reaches experimentally the onset of the strong coupling regime,while numerical simulations predict that vibrational strong coupling can be fully achieved.Phonon polariton nanoresonators thus could become a viable platform for sensing,local control of chemical reactivity and infrared quantum cavity optics experiments. | Marta Autore Peining Li Irene Dolado Francisco J Alfaro-Mozaz Ruben Esteban Ainhoa Atxabal Fèlix Casanova Luis E Hueso Pablo Alonso-González Javier Aizpurua Alexey Y Nikitin Saül Vélez Rainer Hillenbrand | 2017 | Light(Science & Applications)2017，6，1： | 0 |
| 12 | Rubicon: a facilitator of viral immune evasion显示文摘In a study published in cellular and molecular immunology,Wan et al.demonstrate a new mechanism of viral immune evasion.1 It was observed that Rubicon,the RUN domain Beclin-1-interacting and cysteine-rich domain-containing protein,is induced by viral infection and antagonizes interferon(IFN)production,thereby facilitating viral replication.This study not only demonstrates a direct link between Rubicon and NF-κB essential modulator(NEMO),but also demonstrates how the interaction between Rubicon and NEMO inhibits the production of type I interferon.This study shows a previously unrecognized function of Rubicon as an important negative regulator of the innate immune response. | Peining Fang Haisheng Yu Mengqi Li Rui He Ying Zhu Shi Liu | 2019 | Cellular & Molecular Immunology2019，16，9： | 0 |
| 13 | Modeling the pressure drop of wet gas in horizontal pipe显示文摘A model for gas–liquid annular and stratified flow through a horizontal pipe is investigated, using the two-phase hydrokinetics theory. Taking into consideration the flow factors including the void fraction, the friction between the two phases and the entrainment in the gas core, the one-dimensional momentum equation for gas has been solved. The differential pressure of the wet gas between the two tapings in the straight pipe has been modeled in the pressure range of 0.1–0.8 MPa. In addition a more objective iteration approach to determine the local void fraction is proposed. Compared with the experimental data, more than 83% deviation of the test data distributed evenly within the band of ± 10%. Since the model is less dependent on the specific empirical apparatus and data,it forms the foundation for further establishing a flow measurement model of wet gas which will produce fewer biases in results when it is extrapolated. | Peining Yu Yi Li Jing Wei Ying Xu Tao Zhang | 2017 | Chinese Journal of Chemical Engineering2017，25，7： | 0 |
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