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| 1 | Aerobic bacteria associated with chronic suppurative otitis media in Angola显示文摘Background:Chronic suppurative otitis media(CSOM)is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions.Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas.The goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment recommendations.Methods:Samples from ear discharge and the nasopharynx were collected and cultured from 152 patients with ear discharge and perforation of the tympanic membrane.Identification of bacterial species was performed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and pneumococci were serotyped using multiplex polymerase chain reactions.Antimicrobial susceptibility testing was done according to EUCAST.Results:One hundred eighty-four samples from ear discharge and 151 nasopharyngeal swabs were collected and yielded 534 and 289 individual isolates,respectively.In all patients,correspondence rate of isolates from 2 ears in patients with bilateral disease was 27.3%and 9.3%comparing isolates from the nasopharynx and ear discharge,respectively.Proteus spp.(14.7%),Pseudomonas aeruginosa(13.2%)and Enterococcus spp.(8.8%)were dominating pathogens isolated from ear discharge.A large part of the remaining species belonged to Enterobacteriaceae(23.5%).Pneumococci and Staphylococcus aureus were detected in approximately 10%of nasopharyngeal samples.Resistance rates to quinolones exceeded 10%among Enterobacteriaceae and was 30.8%in S.aureus,whereas 6.3%of P.aeruginosa were resistant.Conclusions:The infection of the middle ear in CSOM is highly polymicrobial,and isolates found in nasopharynx do not correspond well with those found in ear discharge.Pathogens associated with CSOM in Angola are dominated by gram-negatives including Enterobacteriaceae and P.aeruginosa,while gram-positive enterococci also are common.Based on the results of antimicrobial susceptibility testing topical quinolones would be the preferred antibiotic therapy of CSOM in Angola.Topical antiseptics such as aluminium acetate,acetic acid or boric acid,however,may be more feasible options due to a possibly emerging antimicrobial resistance. | Fabian Udden Matuba Filipe Ake Reimer Maria Paul Erika Matuschek John Thegerstrom Sven Hammerschmidt Tuula Pelkonen Kristian Riesbeck | 2018 | Infectious Diseases of Poverty2018，7，1： | 6 |
| 2 | Cytotoxicity and biotransformation inducing activity of rodent beddings:a global survey using the Hepa-1 assay 显示文摘 | Pelkonen K H Hanninen OO | 1997 | Toxicology1997，122，12： | 1 |
| 3 | Budesonide improves decreased airway conductance in infants with respiratory symptoms 显示文摘 | Pelkonen AS Malmstrom K Malmberg LP | 2009 | Arch Dis Child2009，94，7： | 1 |
| 4 | Inhibition and induction of human cytochrome P450 enzymes: current status显示文摘 | Pelkonen O Turpeinen M Hakkola J Honkakoski P Hukkanen J Raunio H | 2008 | Arch Toxicol2008，82，10： | 1 |
| 5 | Child and adolescent suicide: epidemiology risk factors, and approaches to prevention显示文摘 | Pelkonen M Marttunem M | 2003 | Paediatr Drugs2003，5，4： | 1 |
| 6 | Perinatal outcome of children born after frozen and fresh embryo transfer:the Finnish cohort study 1995-2006显示文摘 | Pelkonen S Koivunen R Gissler M | 2010 | Hum Reprod2010，25，： | 1 |
| 7 | Inhibition and induction of human cytochrome P450 (CYP) enzymes显示文摘 | Pelkonen O Maenpaa J Taavitsainen P | 1998 | Xenobi-otica1998，28，12： | 1 |
| 8 | Cardiac arrest after interscalene brachial plexus block with ropivacaine and lidocaine显示文摘 | Reinikainen M Hedman A Pelkonen O | 2003 | Acta Anaesthesiol Scand2003，47，： | 1 |
| 9 | Prediction of drug metabolism and interactions on the basis of in vitro investigations 显示文摘 | Pelkonen O Turpeinen M Uusitalo J | 2005 | Basic Clin Pharmacol Toxicol2005，96，3： | 1 |
| 10 | Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung显示文摘 | Hukkanen J Pelkonen O Hakkola J | 2002 | Crit Rev Toxicol2002，32，5： | 1 |
| 11 | Comparison of insulin regimens in the therapy of type 1 diabetes 显示文摘 | PELKONEN R KOIUISTO V MUSTAJOKI P | 1985 | Acta Ehdocrinol Suppl Compenh1985，272，1： | 1 |
| 12 | Systemic immunoresponses in mice after repeated exposure of lungs to spores of streptomyces califomicus 显示文摘 | Jussila J Pelkonen J Kosma VM | 2003 | Clin Diagn Lab Immun2003，10，1： | 1 |
| 13 | Allergy in children:practical recommendations of the Finnish Allergy Programme2008-2018 for prevention,diagnosis,and treatment显示文摘 | Pelkonen A S Kuitunen M Dunder T | 2012 | Pediatric Allergy and Immunology2012，23，2： | 1 |
| 14 | Factors associated with deliberate self-harm behaviour among depressed adolescent outpatients显示文摘 | Tuisku V Pelkonen M Kiviruusu O | | 0，，32： | 1 |
| 15 | Continuous ver- sus intermittent inhaled corticosteroid (budesonide) for mild persistent asthma in children-not too much, not too little 显示文摘 | Turpeinen M Pelkonen A S Selroos O | 2012 | Thorax2012，67，2： | 1 |
| 16 | Intrahepatic Chlolestasis of pregnancy impairs the activities of human placental xenobiotic and steroid metabolizing enzymes in vitro显示文摘 | Pasanen M Pelkonen O Leirkinen P | 1997 | Placenta1997，18，1： | 1 |
| 17 | Airway responsiveness : associated features in infants with recurrent respiratory symptoms 显示文摘 | Kotaniemi-Syrjanen A Malmberg LP Pelkonen AS et aI | 2007 | Eur Respir J2007，30，6： | 1 |
| 18 | Role of gut in xenobiotic metabolism 显示文摘 | Lindstrom-Sppa P Pelkonen K | 1987 | Arch Toxico1987，60，1： | 1 |
| 19 | Ssecondary failure to treatment with oral antidiabetic agents in non-insulin-dependent diabetes显示文摘 | Groop LG Pelkonen R Koskimies S | 1986 | Diabetes Care1986，9，2： | 1 |
| 20 | Omics and its potential impact on R&D and regulation of complex herbal products显示文摘 | Pelkonen O Pasanen M Lindon JC | | 0，，03： | 1 |
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