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| 1 | Rifaximin vs conventional oral therapy for hepatic encephalopathy:A meta-analysis显示文摘AIM: To characterize the efficacy of rifaximin in the management of hepatic encephalopathy (HE) as several randomized controlled studies have shown contradictory results on its effectiveness in comparison to other oral agents. METHODS: We performed a systematic review and random effects meta-analysis of all eligible trials identifi ed through electronic and manual searches. Twelve randomized controlled trials met the inclusion criteria with a total of 565 patients. RESULTS: The clinical effectiveness of rifaximin was equivalent to disaccharides or other oral antibiotics[odds ratio (OR) 0.96; 95% CI: 0.94-4.08] but with a better safety profi le (OR 0.27; 95% CI: 0.12-0.59). At the completion of treatment protocols, patients receiving rifaximin showed lower serum ammonia levels [weighted mean difference (WMD) = -10.65; 95% CI: -23.4-2.1; P = 0.10], better mental status (WMD = -0.24; 95% CI: -0.57-0.08; P = 0.15) and less asterixis (WMD -0.1; 95% CI -0.26-0.07; P = 0.25) without reaching statistical signifi cance. On the other hand, other psychometric outcomes such as electroencephalographic response and grades of portosystemic encephalopathy were superior in patients treated with rifaximin in comparison to the control group (WMD = 0.21, 95% CI: -0.33-0.09, P = 0.0004; and WMD = -2.33, 95% CI: -2.68-1.98, P = 0.00001, respectively). Subgroup and sensitivity analysis did not show any signifi cant difference in the above fi ndings. CONCLUSION: Rifaximin appears to be at least as effective as other conventional oral agents for the treatment of HE with a better safety profi le. | Karim M Eltawil Marie Laryea Kevork Peltekian Michele Molinari | 2012 | World Journal of Gastroenterology2012，18，8： | 9 |
| 2 | Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus: Incidence and prevalence of hepatocellular carcinoma in a North American urban population显示文摘 | Morris Sherman Kevork M. Peltekian Cindy Lee | 1995 | Hepatology1995，，2： | 6 |
| 3 | Evidence-Based Approach to Cholangiocarcinoma: A Systematic Review of the Current Literature显示文摘 | Murad Aljiffry Alhawsawi Abdulelah Mark Walsh Kevork Peltekian Ian Alwayn Michele Molinari | 2008 | Journal of the American College of Surgeons2008，，1： | 3 |
| 4 | Cardiovascular,renal and neurohumoral responses to single large-volume paracentesis in cirrhotic patients with diuretic-resistant ascites显示文摘 | Peltekian KM Wong F Liu PP | 1997 | Am J Gastroenterol1997，92，： | 1 |
| 5 | Orthotopic liver transplantation using low-dose Tacrolimus and Sirolimus显示文摘 | McAlister VC Peltekian KM Malatjalian DA | 2001 | Liver Transpl2001，7，8： | 1 |
| 6 | Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein 显示文摘 | Ordien E RosmorducO Peltekian C | 2001 | J Virol2001，75，： | 1 |
| 7 | Blood borne macrophages are essential for the triggering of muscle regeneration following muscle tansplant显示文摘 | Lescaudron L Peltekian E Fontaine PJ | 1999 | Neuromuscul Disord1999，9，2： | 1 |
| 8 | Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein显示文摘 | Gordien E Rosmorduc O Peltekian C | 2001 | J Virol2001，75，6： | 1 |
| 9 | Human MxA protein partici- pates to the interferon-related inhibition of hepatitis B virus replication in female transgenic mice显示文摘 | Peltekian C Gordien E C mreau F | 2005 | J Hepatol2005，43，6： | 1 |
| 10 | Screening for hepatocellular carcinoma in chronic carriers of hepatitis B virus:incidence and prevalence of hepatocellular carcinoma in a North American urban population显示文摘 | SHEMRMAN M PELTEKIAN K M LEE C | 1995 | Hepatology1995，22，2： | 1 |
| 11 | Inhibition of hepatitis B virus replication by the interferon-inducible Mx A protein显示文摘 | Gordien E Rosmorduc O Peltekian C | 2001 | J Virol2001，75，6： | 1 |
| 12 | Early invasive Listeria rnonocytogenes infection after orthotopic liver transplantation:case report and review of the literature显示文摘 | Kruszyna T Walsh M Peltekian K | 2008 | Liver Transpl2008，14，1： | 1 |
| 13 | Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein显示文摘 | Gordien E Rosmorduc O Peltekian C | 2001 | J Virol2001，75，6： | 1 |
| 14 | Effect of interferon-alpha,ribavirin,pentoxifylline,and interleukin-18antibody on hepatitis C sera-stimulated hepatic stellate cell proliferation显示文摘 | Khan F Peltekian K M Peterson T C | 2008 | J Interferon Cytokine Res2008，28，11： | 1 |
| 15 | Blood borne macrophages are essential for the triggering of muscle regeneration following muscle transplant显示文摘 | Lescaudron L Peltekian E Fontaine-Perus J | 1999 | Neuromuscul Disord1999，9，： | 1 |
| 16 | Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein 显示文摘 | Gordien E Rosmorduc O Peltekian C | 2001 | J Virol2001，75，6： | 1 |
| 17 | Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein显示文摘 | Gordien E Rosmorduc O Peltekian C | 2001 | J Virol2001，75，6： | 1 |
| 18 | A clinical pharmacokinetic study of tacrolimus and sirolimus combination immunosuppression comparing simultaneous to separated administration显示文摘 | McMister VC Mahalati K Peltekian KM | 2002 | Ther Drug Monit2002，24，3： | 1 |
| 19 | Human MxA protein participates to the interferon-related inhibition of hepatitis B virus replication in female transgenic mice 显示文摘 | Peltekian C Gordien E Garreau F | 2005 | J Hepatol2005，43，6： | 1 |
| 20 | Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein 显示文摘 | Gordien E Rosmorduc O Peltekian C | 2001 | J Virot2001，75，6： | 1 |
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