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您的检索式：作者名="Pengbo Guan"
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| 1 | Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis显示文摘While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS), there is an unmet need for treatments that slow neurodegeneration resulting from secondary disease progression. The mechanism of neurodegeneration in MS has not yet been established. Here, we discovered a potential pathogenetic role of ferroptosis, an iron-dependent regulated cell death mechanism, in MS. We found that critical ferroptosis proteins (acyl-CoA synthetase long-chain family member 4, ACSL4) were altered in an existing genomic database of MS patients, and biochemical features of ferroptosis, including lipid reactive oxygen species (ROS) accumulation and mitochondrial shrinkage, were observed in the experimental autoimmune encephalitis (EAE) mouse model. Targeting ferroptosis with ferroptosis inhibitors or reducing ACSL4 expression improved the behavioral phenotypes of EAE mice, reduced neuroinflammation, and prevented neuronal death. We found that ferroptosis was an early event in EAE, which may promote T-cell activation through T-cell receptor (TCR) signaling in vitro and in vivo. These data indicate that ferroptosis may be a potential target for treating MS. | Jinyuan Luoqian Wenyong Yang Xulong Ding Qing-zhang Tuo Zheng Xiang Zhaoyue Zheng Yu-jie Guo Li Li Pengbo Guan Scott Ayton Biao Dong Huiyuan Zhang Hongbo Hu Peng Lei | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 2 | Oblique extension of pre-existing structures and its control on oil accumulation in eastern Bohai Sea显示文摘Based on 3D seismic data, the evolution mechanism and characteristics of faults were investigated to reveal the structural origin and its control on differential hydrocarbon accumulation through comprehensive analyses, including structure style analysis, fault activity analysis, analogue modelling and comparison among the wells. The complex fault system with differently trending faults resulted from strike-slip and rifting in Paleogene was partly activated, developed successively and stretched obliquely by the near-NS extensional stress field in Neogene. In the area little affected by pre-existing faults, new faults nearly perpendicular to the extension direction developed. The structural development in the study area was not caused by transpressional strike slip. Under the oblique extension effect of pre-existing faults, if the angle between the strike of pre-existing fault and the extensional direction is different, the strike-slip and extensional stresses are different in ratio. The larger the angle between the two is, the stronger the extensional component, the poorer the sealing ability of the fault, and the stronger the oil and gas migration capacity will be. Conversely, the smaller the angle between the two is, the stronger the strike-slip component, the better the sealing ability of the fault, and the poorer the oil and gas migration capacity will be. The accumulation condition analysis results considering the fault trend are in good agreement with the oil and gas shows in wells drilled in this area. | REN Jian LYU Dingyou CHEN Xingpeng LIU Pengbo GUAN Dayong SU Kai ZHANG Hongguo | 2019 | Petroleum Exploration and Development2019，46，3： | 0 |
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