1篇
您的检索式：作者名="Penghe Quan"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cationic telluroviologen derivatives as type-I photosensitizers for tumor photodynamic theranostics显示文摘The hypoxia of the tumor microenvironment(TME)seriously restricts the photodynamic therapy(PDT)effect of conventional type-II photosensitizers,which are highly dependent on O_(2).In this work,a new type-I photosensitizer(TPE-TeVPPh3)consisting of a tetraphenylethylene group(TPE)as a bioimaging moiety,triphenyl-phosphine(PPh3)as a mitochondria-targeting group,and telluroviologen(TeV2+)as a reactive oxygen species(O_(2)•−,•OH)generating moiety is developed.The luminescence intensity of TPE-TeV-PPh3 increased significantly after specific oxidation by excess H2O2 in the TME without responding to normal tissues via the formation of Te═O bond,which can be used for monitoring abnormal H2O2,positioning,and imaging of tumors.TPE-TeV-PPh3 with highly reactive radicals generation and stronger hypoxia tolerance realizes efficient cancer cell killing under hypoxic conditions,achieving 88%tumor growth inhibition.Therefore,TPE-TeV-PPh3 with low phototoxicity in normal tissue achieves tumor imaging and effective PDT toward solid tumors in response to high concentrations of H_(2)O_(2)in the TME,which provides a new strategy for the development of type-I photosensitizers. | Qi Sun Qi Su Yujing Gao Kun Zhou Weijie Song Penghe Quan Xiaojian Yang Zhishen Ge Yanmin Zhang Gang He | 2023 | Aggregate2023，4，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员