| 1 | Discovery and inspiration of large-and medium-sized glutenite-rich oil and gas fields in the eastern South China Sea:An example from Paleogene Enping Formation in Huizhou 26 subsag,Pearl River Mouth Basin显示文摘Based on the practice of oil and gas exploration in the Huizhou Sag of the Pearl River Mouth Basin,the geochemical indexes of source rocks were measured,the reservoir development morphology was restored,the rocks and minerals were characterized microscopically,the measured trap sealing indexes were compared,the biomarker compounds of crude oil were extracted,the genesis of condensate gas was identified,and the reservoir-forming conditions were examined.On this basis,the Paleogene Enping Formation in the Huizhou 26 subsag was systematically analyzed for the potential of oil and gas resources,the development characteristics of large-scale high-quality conglomerate reservoirs,the trapping effectiveness of faults,the hydrocarbon migration and accumulation model,and the formation conditions and exploration targets of large-and medium-sized glutenite-rich oil and gas fields.The research results were obtained in four aspects.First,the Paleogene Wenchang Formation in the Huizhou 26 subsag develops extensive and thick high-quality source rocks of semi-deep to deep lacustrine subfacies,which have typical hydrocarbon expulsion characteristics of'great oil generation in the early stage and huge gas expulsion in the late stage',providing a sufficient material basis for hydrocarbon accumulation in the Enping Formation.Second,under the joint control of the steep slope zone and transition zone of the fault within the sag,the large-scale near-source glutenite reservoirs are highly heterogeneous,with the development scale dominated hierarchically by three factors(favorable facies zone,particle component,and microfracture).The(subaqueous)distributary channels near the fault system,with equal grains,a low mud content(<5%),and a high content of feldspar composition,are conducive to the development of sweet spot reservoirs.Third,the strike-slip pressurization trap covered by stable lake flooding mudstone is a necessary condition for oil and gas preservation,and the NE and nearly EW faults obliquely to the principal stress have the best control on traps.Fourth,the spatiotemporal configuration of high-quality source rocks,fault transport/sealing,and glutenite reservoirs controls the degree of hydrocarbon enrichment.From top to bottom,three hydrocarbon accumulation units,i.e.low-fill zone,transition zone,and high-fill zone,are recognized.The main area of the channel in the nearly pressurized source-connecting fault zone is favorable for large-scale hydrocarbon enrichment.The research results suggest a new direction for the exploration of large-scale glutenite-rich reservoirs in the Enping Formation of the Pearl River Mouth Basin,and present a major breakthrough in oil and gas exploration. | XU Changgui GAO Yangdong LIU Jun PENG Guangrong LIU Pei XIONG Wanlin SONG Penglin | 2024 | Petroleum Exploration and Development2024，51，1： | 0 |
| 2 | Equilibria between the K^+ binding and cation vacancy conformations of potassium channels显示文摘Dear Editor, Potassium channels are integral membrane proteins that selectively con duct K^+ ions across cell membra ne (Hille, 2001). They play essential roles in maintaining cellular ionic homoeostasis and generating action membrane potentials in excitable cells. The mechanism of K^+ selectivity has been evaluated in many biophysical and physiological studies (Zhou et al., 2001;Liu et al., 2015;Schewe et al., 2016). A highly con served signature seque nee, TVGYG, in the selectivity filter of potassium channels (e.g., KcsA) is known to coordinate K^+ ions (Zhou et al., 2001). Carbonyls of these residues point toward the pore, forming four continuous ion binding sites (S1-S4) and resulting in higher selectivity for K^+ over Na^+(Zhou et al., 2001). The NaK channel from Bacillus cereus is a norvselective cation channel that shares high structural homology with KcsA (Shi et al., 2006). Owing to a distinctive primary sequenee of 63TVGDG67, the selectivity filter of NaK preserves only two ion binding sites, allocated similarly as S3 and S4 in KcsA (Alam and Jiang, 2009a, b). Remarkably, the D66Y and N68D double mutations of NaK channel (Fig. S1) transform it into a K^+ selective channel (termed as NaK2K)(Sauer et al., 2013). Crystal structure of NaK and NaK2K have revealed distinet binding coordination of Na^+ and K^+ ions in their selectivity filter (Figs. S2 and S3)(Alam and Jiang, 2009a, b;Sauer et al., 2013). However, dynamics of the NaK and NaK2K selectivity filter with the bind泊g of Na+ or K^+ are still elusive. Especially, it has been known that the membrane environment is highly diverse from deterge nt micelles, which was con sidered to in flue nee the structure and functi on of membrane protei ns dramatically (Cross et al., 2011). Thus, it is necessary to study the cation and binding properties of NaK NaK2K channels in lipid bilayers. | Yao He Bo Zhang Hao Dong Penglin Xu Xiaoying Cai Ting Zhou Mu Yu Jun Liang Xiao Zheng Changlin Tian | 2019 | Protein & Cell2019，10，7： | 0 |
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