3篇
您的检索式：作者名="Pengze Yan"
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| 1 | A single-cell transcriptomic atlas of primate pancreatic islet aging显示文摘Aging-related degeneration of pancreatic islet cells contributes to impaired glucose tolerance and diabetes.Endocrine cells age heterogeneously,complicating the efforts to unravel the molecular drivers underlying endocrine aging.To overcome these obstacles,we undertook single-cell RNA sequencing of pancreatic islet cells obtained from young and aged non-diabetic cynomolgus monkeys.Despite sex differences and increased transcriptional variations,agedβ-cells showed increased unfolded protein response(UPR)along with the accumulation of protein aggregates.We observed transcriptomic dysregulation of UPR components linked to canonical ATF6 and IRE1 signaling pathways,comprising adaptive UPR during pancreatic aging.Notably,we found aging-relatedβ-cell-specific upregulation of HSP90 B1,an endoplasmic reticulum-located chaperone,impeded high glucose-induced insulin secretion.Our work decodes aging-associated transcriptomic changes that underlie pancreatic islet functional decay at single-cell resolution and indicates that targeting UPR components may prevent loss of proteostasis,suggesting an avenue to delayingβ-cell aging and preventing aging-related diabetes. | Jingyi Li Yuxuan Zheng Pengze Yan Moshi Song Si Wang Liang Sun Zunpeng Liu Shuai Ma Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Weiqi Zhang Guang-Hui Liu Fuchou Tang Jing Qu | 2021 | National Science Review2021，8，2： | 3 |
| 2 | Protein quality control of cell stemness显示文摘Protein quality control(PQC)systems play essential roles in the recognition,refolding and clearance of aberrant proteins,thus ensuring cellular protein homeostasis,or proteostasis.Especially,continued proliferation and differentiation of stem cells require a high rate of translation;therefore,accurate PQC systems are essential to maintain stem cell function.Growing evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem cells.This review focuses on current knowledge regarding the components of the proteostasis network in stem cells,and the importance of proteostasis in maintaining stem cell identity and regenerative functions.A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases. | Pengze Yan Jie Ren Weiqi Zhang Jing Qu Guang-Hui Liu | 2020 | Cell Regeneration2020，9，1： | 1 |
| 3 | Numerical simulation and experimental research on oscillation performance of disc-type jet oscillator显示文摘Based on active flow control technology,the two wall jets attached to a standard cylindrical surface due to the Coanda effect will output a detached jet when they collide.The direction of the output jets produced by this collision is very sensitive to small changes in the two wall jets.Therefore,a new type of curved-wall supersonic compressible disc-type jet oscillator is proposed by using the oscillating feedback jet as the source of wall separation.Through monitoring the internal flow field,the jet core’s pressure attenuation,the jet’s amplitude,and the wall pressure are analyzed.The results show that the disc-type jet oscillator model with a double-bend inlet has the best performance.After adding a multi-pipe outlet structure to the model,the oscillators with various disc diameters were simulated at different inlet pressures and air inlet frequencies to the wall-off control port.The oscillation performance of the disc jet oscillator is better when the diameter of the disc is 32 mm and 20 mm,and the included angle between the wall-off control port and the horizontal direction is 45°.Two kinds of oscillators of the same diameter as the model are experimentally studied,and the results prove the feasibility of the disc-type jet oscillator. | Wutekuer NUERMAIMAITI Xuewu LIU Pengze YAN Zongrui WANG Dapen HU | 2023 | Chinese Journal of Aeronautics2023，36，10： | 0 |
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