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| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | Charaterizations of generalized convexities via generalized directional derivative显示文摘 | Sach P H Penot J P | | 0，，： | 1 |
| 3 | Contribu- tion to porous mullite synthesis from clays by adding A1 and Mg powders 显示文摘 | ESHARGHAWI A PENOT C NARDOU F | 2009 | Journal of the European Ceramic Society2009，29，1： | 1 |
| 4 | Synergism between ER alpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains显示文摘 | Penot G Flouriot G | 2001 | Mol Endocrinol2001，15，11： | 1 |
| 5 | The drop theorem, the petal theorem and Ekeland's variational principle显示文摘 | Penot I P | 1986 | Nonlinear Analysis1986，10，： | 1 |
| 6 | Semi-continuous mappings in general topology显示文摘 | Penot J P Thera M | 1982 | Archiy der Mathematik1982，38，： | 1 |
| 7 | Generalized convexity of functions and generalized monotonicity of set-valued maps显示文摘 | Penot J P Quang P H | 1997 | J Optim Theory Appl1997，92，： | 1 |
| 8 | A new constraint qualification condition显示文摘 | J. P. Penot | 1986 | Journal of Optimization Theory and Applications1986，，3： | 1 |
| 9 | Fixed point theorems without convexity显示文摘 | Penot J P | 1979 | Bull Soc Math France1979，60，： | 1 |
| 10 | Characterizaion of Solution Sets of Quasiconvex Programs显示文摘 | PENOT J P | 2003 | Journal of Optimization Theory and Applications2003，117，3： | 1 |
| 11 | Lower Subdifferentiability and Integration显示文摘 | BACHIR M DANIILIDIS A PENOT J P | 2002 | Set-Valued Analysis2002，10，1： | 1 |
| 12 | Differentiability of relations and differential stability of perturbed optimization problems显示文摘 | PENOT J P | 1984 | SIAM J Control Optim1984，22，： | 1 |
| 13 | On minimizing and critical sequences in nonsmooth optimization 显示文摘 | HUANG L R NG K F PENOT J P | 2000 | SIAM Journal on Optimization2000，，10： | 1 |
| 14 | Contribution to porous mullite synthesis from clays by adding A1 and Mg powders 显示文摘 | Esharghawi A Penot C Nardou F | 2009 | Journal of the European Ceramic Society2009，29，1： | 1 |
| 15 | Metric regularity, openness and Lipschitzian behavior of multifunctions显示文摘 | Penot J-P | 1989 | Nonlinear Anal: Theory Methods Appl1989，13，62： | 1 |
| 16 | China and the relationship between the oil price and the dollar显示文摘 | Agnes Benassy-Quere Valerie Mignon Alexis Penot | 2007 | Energy Policy2007，，35： | 1 |
| 17 | The influence of thermal instabilities on the initial conditions of the backdraft phenomenon显示文摘 | GUIGAY G MOST JM PENOT F | 2010 | Combustion Science and Technology2010，182，46： | 1 |
| 18 | Oxidation resistance of Nd-Si-Al-O-N glasses and glass-ceramics 显示文摘 | SEBAI M PENOT C GOURSAT P | 1998 | J Eur Ceram Soc1998，18，2： | 1 |
| 19 | Generalized monotonicity of s ubdifferentials and generalized convexity显示文摘 | Penot J P Sach P H | 1997 | Journal of Optimization Theory and Applications1997，94，： | 1 |
| 20 | Generalized Convexity of Functions and Generalized Monotonicity of Set-Valued Maps 显示文摘 | PENOT J P QUANG P H | 1997 | Journal of Optimization Theory and Applications1997，92，2： | 1 |
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