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33篇 您的检索式：作者名="Perring A E"

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	题名	作者	年代	出处	被引量
1	CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL.	Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed	2018	Cellular & Molecular Immunology2018，15，2：	2
2	Design of PID-type controllers using multiobjective genetic algorithms显示文摘	Herreros A Baeyens E Perán J R	2002	Isa Transactions2002，41，4：	1
3	Association of the nucleic acid of squash leaf curl geminivirus with the whitefly Bemisia tabaci显示文摘	Polston J E A1-Musa A Perring T M Dodds J A		0，，：	1
4	High-speed heck reactions in ionic liquid with controlled microwave heating 显示文摘	KARL S A V PER E MATS L	2002	J Org Chern2002，67，17：	1
5	Report of the ad hoc committee for the reevaluation of the species definition in bacteriology显示文摘	Stackebrandt E Frederiksen W Garrity GM Grimont PAD K(a)mpfer P Maiden MCJ Nesme X Rosselló-Mora R Swings J Trüper HG Vauterin L Ward AC Whitman WB		0，，：	1
6	Effects of slow and fast pyrolysis biochar on soil C and N turnover dynamics 显示文摘	Esben W B Per A Helge E	2012	Soil Biology & Biochemistry2012，46，1：	1
7	Int racellularglutathione and cytotoxicit y of plat inumcomplexes 显示文摘	PENDYALA L CR EAVEN P J PER EZ R e t a l	1995	Cancer Chemother Pharmacol1995，36，4：	1
8	Direct measurements of the convective recycling of the upper tropo- sphere显示文摘	Bertram T H Perring A E Wooldridge P J	2007	Science2007，315，5813：	1
9	Effect of prolonged heat treatment from 48℃ to 63℃ on toughness, cooking loss and color of pork 显示文摘	Line C Per E Margit D A	2011	Meat Science2011，88，2：	1
10	EIS studyof heat-treated Al-Zn-Mg alloys in the passive and transpassivepotential region显示文摘	CABOT P L GARRIDO J A PEREZ E PERéZ A H	1995	Electrochimica Acta1995，40，4：	1
11	Local Infiltration Analgesia Versus Intrathecal Morphine for Postoperative Pain Management After Total Knee Arthroplasty:A Randomized Control ed Trial显示文摘	Per E Kjel A Elisabeth A		0，，04：	1
12	Polymicrogyria: corre-lation of magnetic resonance imaging and clinical findings显示文摘	Mavili E Coskun A Per H	2012	Childs Nerv Syst2012，28，6：	1
13	Mea- suring the Efficiency of Decision Making Units 显示文摘	CHARNES A CIX)PER W W RHODES E	1978	European Journal of Operational Research1978，2，6：	1
14	4-Hydroxyphenylpyruvate dioxygenase: A hybrid density functional study of the catalytic reaction mechanism显示文摘	Borowski T Bassan A Per E M	2004	Biochemistry2004，43，12：	1
15	Electronic and magnetic properties of neutral and charged quinone and plastoquinone radicals 显示文摘	Leif A Eriksson Fahmi Himo Per E M S	1997	J Phys Chem1997，101，：	1
16	Character- istics of Black Carbon Aerosol from a Surface Oil Bum Dur- ing the Deepwater Horizon Oil Spill 显示文摘	Perring A E Schwarz J P Spackman J R	2011	Geophy Res Lett2011，38，17：	1
17	Dehydration of water/dichloromethane/n-butanol mixtures by pervaporation;optimisation and modelling by response surface methodology显示文摘	GARC(I)A V LANDABURU-AGUIRRE J PONGR(A)CZ E PER(A)M(A)KI P KEISKI R L		0，，：	1
18	Polymicrogyria: corre-lation of magnetic resonance imaging and clinical findings显示文摘	Mavili E Coskun A Per H	2012	Childs Nerv Syst2012，28，6：	1
19	Comparison of tropospheric NO2 from in situ aircraft measurements with near-real-time and standard product data from OMI显示文摘	Buesela E Perring A Cohen R	2008	Journal of Geophysical Research: Atmospheres (1984-2012)2008，113，16：	1
20	Dextran sodium sulphate colitis mouse model:traps and tricks显示文摘	Pere M Cerar A	2012	J Biomed Biotechnol2012，2012，71：	1

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