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| 1 | Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology显示文摘Virtually all drug interventions that have been successful pre-clinically in experimental stroke have failed to prove their efficacy in a clinical setting. This could be partly explained by the complexity and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efficacious in clinical practice. One aspect of crucial importance in the physiopathology of stroke which is not completely understood is neuroinflammation. At the present time, it is becoming evident that subtle, but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity, hypertension, diabetes and atherosclerosis could act as 'silent contributors' promoting a chronic proinflammatory state. This could aggravate the outcome of various pathological entities and can contribute to a number of subsequent post-stroke complications such as dementia, depression and neurodegeneration creating a pathological vicious cycle. Moreover, recent data suggests that the inflammatory process might be closely linked with multiple neurodegenerative pathways related to depression. In addition, pro-inflammatory cytokines could play a central role in the pathophysiology of both depression and dementia. | Raluca Elena Sandu Ana Maria Buga Adriana Uzoni Eugen Bogdan Petcu Aurel Popa-Wagner | 2015 | Neural Regeneration Research2015，10，9： | 6 |
| 2 | Dietary habits, lifestyle factors and neurodegenerative diseases显示文摘Worldwide stroke is increasing in parallel with modernization,changes in lifestyle,and the growing elderly population.Our review is focused on the link between diet,as part of‘modern lifestyle’,and health in the context of genetic predisposition of individuals to‘unhealthy’metabolic pathway activity.It is concluded that lifestyle including high sugar diets,alcohol and tobacco addiction or high fat diets as well as ageing,brain injury,oxidative stress and neuroinflammation,negatively influence the onset,severity and duration of neurodegenerative diseases.Fortunately,there are several healthy dietary components such as polyunsaturated fatty acids and the anti-oxidants curcumin,resveratrol,blueberry polyphenols,sulphoraphane,salvionic acid as well as caloric restriction and physical activity,which may counteract ageing and associated neurodegenerative diseases via increased autophagy or increased neurogenesis in the adult brain. | Aurel Popa-Wagner Dinu Iuliu Dumitrascu Bogdan Capitanescu Eugen Bogdan Petcu Roxana Surugiu Wen-Hui Fang Danut-Adrian Dumbrava | 2020 | Neural Regeneration Research2020，15，3： | 3 |
| 3 | The effect of HRG gas addition on diesel engine combustion characteristics and exhaust emissions显示文摘 | Adrian Birtas Iulian Voicu Cristian Petcu Radu Chiriac Nicolae Apostolescu | 2011 | International Journal of Hydrogen Energy2011，，18： | 1 |
| 4 | Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: perform ance and questionnaire data显示文摘 | Nicolescu R Petcu C Cordeanu A | | Environ Res0，110，： | 1 |
| 5 | Masticatory tensile developed in upper anterior teeth with chronic apical pc-riodontitis: a finite-element analysis study 显示文摘 | Petcu CM Nitoi D Mercut V | 2013 | Rom J Morphol Embryol2013，54，3： | 1 |
| 6 | Role of kinin B 1 and B2 receptors in a rat model of neuropathie pain 显示文摘 | Petcu M Dias JP Ongali B | 2008 | Int Immunopharmacol2008，8，2： | 1 |
| 7 | The effect of drought stress on fatty acid composition in some Romanian sun- flower hybrids 显示文摘 | Petcu E Arsintescu A Stanciu D | 2011 | Romanian Agri Res2011，15，： | 1 |
| 8 | Multi-GPU implementation of the minimum volume sirnplex analysis algorithm for hyperspectral unmixing 显示文摘 | Agathos A Li J Petcu D | 2014 | IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing2014，7，6： | 1 |
| 9 | Follicular variant of papillary thyroid carcinoma : a diagnostic challenge for clinicians and pathologists显示文摘 | Salajegheh A Petcu EB Smith RA | 2008 | Postgrad Med J2008，84，988： | 1 |
| 10 | Ternary microemulsions of vinylic and acrylic monomers 显示文摘 | Dan Donescu Liana Fusulan Cristian Petcu | 2002 | European Polymer Journal2002，38，： | 1 |
| 11 | Follicular variant of papillary thyroid carcinoma: a diagnostic challenge for clinicians and pathologists显示文摘 | Salajegheh A Petcu EB Smith RA | 2008 | Postgrad Med J2008，84，988： | 1 |
| 12 | Follicular variant of papillary thyroid carcinoma:a diagnostic challenge for clinicians and pathologists显示文摘 | Salajegheh A Petcu EB Smith RA | 2008 | Postgrad Med J2008，84，988： | 1 |
| 13 | Effects of alpha-lipoic acid on kinin B1 and B2 receptor binding sites in the spinal cord of chronically angiotensin-treated rats显示文摘 | Petcu M Ongali B EI Midaoui A | 2005 | Peptides2005，26，8： | 1 |
| 14 | Available rotation capacity of wide- flange beams and beam-columns : 1 : theoretical approaches 显示文摘 | Gioncu V Petcu D | 1997 | Journal of Constructional Steel Research1997，43，123： | 1 |
| 15 | Rotation capacity of wide-flange beams and beam-columns : 2 : experimental and numerical tests 显示文摘 | Gioncu V Petcu D | 1997 | Journal of Constructional Steel Research1997，43，123： | 1 |
| 16 | Propofol-imprinted membranes with potential applications in biosensors显示文摘 | PETCU M | 2004 | Analytica Chimica Acta2004，504，1： | 1 |
| 17 | Electrically induced protoplast fusion for ergosterol-producing yeast strain improvement显示文摘 | Avram D Petcu I Radu M Dan F Stan R | 1992 | Basic Microbiol1992，32，6： | 1 |
| 18 | Symbolic computations based on grid services显示文摘 | PETCU D BONCHIS C IZBASA C | 2006 | International Journal of Computers Communications & Control2006，1，1： | 1 |
| 19 | The ellect ot HRG gas addition on diesel engine combustion characteristics and exhaust emissions显示文摘 | Adrian Birtas Iulian Voieu Cristian Petcu | 2011 | International Journal of Hydrogen Energy2011，36，12： | 1 |
| 20 | Polymer-silica hybrids obtained by microemulsion polymerization显示文摘 | DONESCU D SERBAN S PETCU C | 2007 | Colloid Polym Sci2007，285，： | 1 |
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