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| 1 | 应用组织追踪法评价左室功能的研究显示文摘目的 用超声心动图组织追踪法评价左室功能。方法 对 90例具有不同左室收缩功能患者的心尖四腔心、心尖长轴和心尖二腔心切面 ,用组织追踪法和M型超声心动图法记录收缩期二尖瓣瓣环向心尖方向的运动位移。所有患者均用Simpson方法确定左室射血分数 ,其中 2 7例患者又做了左室造影。 结果 在 5 0例患者中 (包括 2 5例正常左室功能患者和 2 5例左室整体功能减退患者 ) ,组织追踪法从二尖瓣环的 6个位置测得的收缩期平均二尖瓣瓣环距离与M型测得的值非常接近 (r =0 .99,P <0 .0 0 1) ,与左室射血分数的相关性很匹配 (r =0 .97,P <0 .0 0 1)。用组织追踪法测定的收缩期二尖瓣瓣环下移距离 4.8mm作为一个切断点的值(cut ofvalue) ,预测左室射血分数≤ 30 %的敏感性为 98%,特异性为 78%。但在陈旧性心肌梗死患者中 ,组织追踪法从二尖瓣瓣环的 6个位置测得的收缩期平均二尖瓣瓣环下移的距离与左室射血分数的相关性是较低的 (r= 0 .87,P <0 .0 0 1)。结论 组织追踪法测收缩期二尖瓣瓣环下移距离可为临床提供一种简单快速和无创伤性评价左室功能的方法。 | 潘翠珍 舒先红 陈灏珠 Rainer Hoffmann Peter Hanrath | 2001 | 中华超声影像学杂志2001，10，12： | 58 |
| 2 | 组织追踪法快速而精确评价心梗患者左室功能显示文摘目的 :本研究旨在用一种新的超声心动图技术—组织追踪法评价心梗患者左室节段收缩功能。方法 :我们研究 4 0例陈旧性心梗患者和 2 5例左室收缩功能正常对照组 ,在心尖四腔心、三腔心和二腔心切面 ,用组织追踪法和 M型超声心动图法记录收缩期二尖瓣瓣环向心尖方向的运动位移。所有患者均用 Simpson s方法确定左室射血分数 ,其中 2 7例患者又做了对比造影。结果 :在陈旧性心梗患者中 ,组织追踪法从二尖瓣瓣环的 6个位置测得的收缩期平均二尖瓣瓣环下移的距离与 M- mode测得的距离相关性很匹配 (r=0 .98,P<0 .0 0 1) ,与左室射血分数的相关性很好 (r=0 .87,P<0 .0 0 1)。陈旧性心梗节段收缩减退患者与正常左室收缩功能患者的比较 ,收缩期二尖瓣瓣环下移距离在 6个位置都是有意义地减少 ,而且收缩期二尖瓣瓣环下移距离在 6个位置之间有较大的异质性。结论 :组织追踪法测收缩期二尖瓣瓣环下移距离为临床提供了一种简单的。 | 潘翠珍 Rainer Hoffmann Peter Hanrath 舒先红 陈灏珠 | 2002 | 中国超声医学杂志2002，18，2： | 22 |
| 3 | Effect of humic substances on the precipitation of calcium phosphate显示文摘For phosphorus (P) recovery from wastewater, the effect of humic substances (HS) on the precipitation of calcium phosphate was studied. Batch experiments of calcium phosphate precipitation were undertaken with synthetic water that contained 20 mg/L phosphate (as P) and 20 mg/L HS (as dissolved organic carbon, DOC) at a constant pH value in the range of 8.0—10.0. The concentration variations of phosphate, calcium (Ca) and HS were measured in the precipitation process; the crystalline state and compositions of the precipitates were analysed by powder X-ray diffraction (XRD) and chemical methods, respectively. It showed that at solution pH 8.0, the precipitation rate and removal efficiency of phosphate were greatly reduced by HS, but at solution pH ≥9.0, the effect of HS was very small. The Ca consumption for the precipitation of phosphate increased when HS was added; HS was also removed from solution with the precipitation of calcium phosphate. At solution pH 8.0 and HS concentrations ≤ 3.5 mg/L, and at pH ≥ 9.0 and HS concentrations ≤ 10 mg/L, the final precipitates were proved to be hydroxyapatite (HAP) by XRD. The increases of solution pH value and initial Ca/P ratio helped reduce the influence of HS on the precipitation of phosphate. | SONG Yong-hui Hermann H. HAHN Erhard HOFFMANN Peter G. WEIDLER | 2006 | Journal of Environmental Sciences2006，18，5： | 11 |
| 4 | Prevalence and risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel diseases:A cross-sectional and longitudinal analysis显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is common in the German population,with an even higher prevalence in inflammatory bowel disease patients.AIM To investigate the risk factors for NAFLD in inflammatory bowel disease patients.METHODS This monocentric retrospective study with a cross-sectional and a longitudinal part included 694 patients.Inclusion criteria were diagnosed inflammatory bowel disease,age≥18 years,availability of at least one abdominal ultrasound.Patients with infectious or suspected alcoholic fatty liver disease were excluded.NAFLD was defined by increased echogenicity at liver ultrasound.Demographic characteristics,disease activity and medications were analyzed as potential risk factors.Parameters influencing the course of NAFLD were identified by a generalized linear mixed model.RESULTS Forty-eight percent of Crohn’s disease(CD)patients and 44%of ulcerative colitis patients suffered from NAFLD.Its occurrence was associated with greater age,hypertension and body mass index(BMI)in both groups,and with higher disease activity and dyslipidemia in CD.2467 ultrasound results were included in the longitudinal analysis.Risk factors for NAFLD were age,BMI,higher disease activity,bowel resection(s),endoscopic activity and azathioprine use in CD;and BMI and endoscopic activity in ulcerative colitis.CONCLUSION NAFLD was highly prevalent in this cohort of German inflammatory bowel disease patients.Its risk increased mainly with rising age and BMI.This analysis provides a rationale for non-invasive liver screening in inflammatory bowel disease patients. | Peter Hoffmann Victoria Jung Rouven Behnisch Annika Gauss | 2020 | World Journal of Gastroenterology2020，26，46： | 8 |
| 5 | 大鼠肾移植1000例经验总结显示文摘目的:对大鼠肾移植进行经验总结以指导实验与临床研究。方法:作者在2004-01/2009-07海德堡大学移植中心期间,采用大鼠肾动、静脉与腹主动脉、腔静脉行端侧吻合。对于急性肾移植模型,输尿管直接植入膀胱内;对于慢性肾移植模型,输尿管采用端端吻合法。术中直接切除对侧肾脏,完成大鼠肾移植1000例,并对其进行总结。结果:只要供体肾脏冲洗良好,吻合时暖缺血时间小于30min,手术时间60min左右,吻合技术娴熟,移植成功率达98%以上。结论:该实验模型安全、方便、可行。肾移植成功的关键是手术技术。 | 李占清 关晓海 王世军 陈晶 伊雪 邬鹏宇 肖志 Nickkholgh Arash Bruns Helge Hoffmann Katrin Schemmer Peter | 2011 | 中国组织工程研究与临床康复2011，15，5： | 7 |
| 6 | 糖基化终产物对脉络膜微血管内皮细胞增生和管腔形成的影响(英文)显示文摘目的:研究糖基化终产物(advanced glycationendproducts, AGEs)在年龄相关性黄斑变性发生中的作用。方法:使用lycopersiconesculentum agglutinin包被磁珠的改良方法分离牛脉络膜微血管内皮细胞(bovine choroidalendothelialcells, CEC),采用抗VIII因子免疫细胞化学法和摄取低密度脂蛋白(dil-acetylated low-density lipoprotein,dil-ac-LDL)法进行细胞鉴定。将50g/L牛血清白蛋白和150g/L葡萄糖在37℃孵育6wk 以制备AGEs,通过抗-AGEs 抗体点杂交法定性分析。用MTT 法(3,(4,5-dimethylthiazol-2-yl)-2,5- diphenyl te-trazolium bromide assay)测定CEC 增生,用Vit-rogen凝胶系统观察管腔形成情况。结果:培养细胞中90%以上呈因子阳性,并具有摄取dil-ac-LDL的能力,表明具有内皮细胞的特征。制备的AGEs 与抗-AGEs 抗体具有亲和力。浓度在62.5~500mg/L范围内的AGEs 处理CEC 3d 后,细胞增生呈剂量依赖性增加。碱性成纤维细胞生长因子(basic fibroblastgrowth factor, bFGF)可明显增强CEC 中管腔样结构的形成(P <0.05),但500mg/L和50mg/L的AGEs 对CEC 管腔形成无明显影响(P >0.05)。结论:AGEs 可以促进CEC 的增生,但对其管腔形成无影响。提示AGEs 通过增强CEC 增生,可能是渗出型AMD 发病中潜在的启动因子之一? | 王雨生 Ulrike Friedrichs Wolfram Eichler Stephan Hoffmann Peter Wiedemann | 2005 | 国际眼科杂志2005，5，2： | 3 |
| 7 | The Energy Efficiency Gap in Maritime Transport显示文摘 | Michele Acciaro Peter Nyegaard Hoffmann Magnus Strandmyr Eide | 2013 | Journal of Shipping and Ocean Engineering2013，3，1： | 2 |
| 8 | Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis显示文摘BACKGROUND Acute severe ulcerative colitis unresponsive to systemic steroid treatment is a lifethreatening medical condition requiring hospitalization and often colectomy.Despite the increasing choice of medical therapy options for ulcerative colitis, the condition remains a great challenge in the field of inflammatory bowel diseases(IBD). The performance of the calcineurin inhibitor tacrolimus in this clinical setting is insufficiently elucidated.AIM To evaluate the short and long-term outcomes of tacrolimus therapy in adult inpatients with steroid-refractory acute severe ulcerative colitis.METHODS We conducted a retrospective monocentric study enrolling 22 patients at a tertiary care center for the treatment of IBD. All patients who were admitted to one of the wards of the Department of Gastroenterology and Hepatology of the Heidelberg University Hospital with acute severe ulcerative colitis between 2007 and 2018, and who received oral or intravenous tacrolimus for steroid-refractory disease were included. Baseline characteristics and data on the disease courses were retrieved from entirely computerized patient charts. The primary study endpoint was clinical response to tacrolimus therapy, resulting in discharge from the hospital. Secondary study endpoints were colectomy rate and time to colectomy, achievement of clinical remission under tacrolimus therapy, and the occurrence of side effects.RESULTSIn the majority of the 22 included patients(68.2%), tacrolimus therapy was initiated intravenously and subsequently converted to oral administration. The treatment duration was 128 ± 28.5 d(mean ± SEM), and the patients were followed up for 705 ± 110 d after treatment initiation. Among all patients, 86.4%were discharged from the hospital under continued oral tacrolimus therapy. In36.4% of the patients, the administration of tacrolimus resulted in clinical remission at some point during the treatment. Thirty-two percent of the patients underwent colectomy between 5 and 194 d after the initiation of tacrolimus treatment(mean: 97.4 ± 20.8 d). Colectomy-free survival rates at 1, 3, 6 and 12 mo after the initiation of tacrolimus therapy were 90.9%, 86.4%, 77.3% and 68.2%,respectively. The safety profile of tacrolimus was overall favorable. Only two patients discontinued the treatment due to side effects.CONCLUSION The short-term outcome of tacrolimus in steroid-refractory acute severe ulcerative colitis was beneficial, and side effects were rare. In all, tacrolimus therapy appears to be a viable option for short-term treatment of steroidrefractory acute severe ulcerative colitis besides ciclosporin and anti-tumor necrosis factor α treatment. | Peter Hoffmann Cyrill Wehling Johannes Krisam Jan Pfeiffenberger Nina Belling Annika Gauss Department of | 2019 | World Journal of Gastroenterology2019，25，13： | 2 |
| 9 | Potential mechanisms of the acute coronary syndrome presentation in patients with the coronary slow flow phenomenon — Insight from a plasma proteomic approach显示文摘 | Victoria A. Kopetz Megan A.S. Penno Peter Hoffmann David P. Wilson John F. Beltrame | 2011 | International Journal of Cardiology2011，，1： | 2 |
| 10 | Acute hepatitis induced by an Aloe vera preparation: A case report显示文摘AIM: Aloe vera, plant extracts of Aloe barbadensis miller,is widely used in phytomedicine. The first case of acute hepatitis due to this compound was described.METHODS: Description of a clinical case.RESULTS: Hepatitis in a 57-year old female could be linked to the ingestion of Aloe barbadensis miller compounds. The patient's hepatitis resolved completely after discontinuing this medication.CONCLUSION: The case emphasizes the importance of considering phytopharmaceutical over-the-counter drugs as causative agents of hepatitis. | Christian Rabe Annemarie Musch Peter Schirmacher Wolfgang Kruis Robert Hoffmann | 2005 | World Journal of Gastroenterology2005，11，2： | 2 |
| 11 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 12 | Komplikationen nach Hochdosistherapie und autologer Stammzelltransplantation Retrospektive Untersuchung an einem nicht selektionierten Patientenkollektiv显示文摘 | Martin Hoffmann Dirk Henrich Ulrich Hackenberg Dirk Mewes Peter Hellstern Michael Uppenkamp | 2001 | Medizinische Klinik2001，，4： | 2 |
| 13 | 13-cis-retinoic acid and interferon-a +Irradiation in the treatment of squamous cell carcinomas显示文摘 | Martina Schiebe Peter Hirnle | 1997 | Int J Cancer1997，70，： | 1 |
| 14 | The two faces of market support—How deployment policies affect technological exploration and exploitation in the solar photovoltaic industry显示文摘 | Joern Hoppmann Michael Peters Malte Schneider Volker H. Hoffmann | 2013 | Research Policy2013，，： | 1 |
| 15 | Central hepatectomy: The golden mean for treating central liver tumors?显示文摘 | Charalabos Stratopoulos Zahir Soonawalla Jens Brockmann Kathrin Hoffmann Peter J. Friend | 2007 | Surgical Oncology2007，，2： | 1 |
| 16 | An Intervention Study to Enhance Girls' Interest,Self-Concept,and Achievement in physics Classes显示文摘 | Peter Haussler Lore Hoffmann | 2002 | Journal of Research in Science Teaching2002，，9： | 1 |
| 17 | Surgical Management of Pulmonary Metastases from Colorectal Cancer in 153 Patients显示文摘 | Süleyman Yedibela Peter Klein Karsta Feuchter Martin Hoffmann Thomas Meyer Thomas Papadopoulos Jonas G?hl Werner Hohenberger | 2006 | Annals of Surgical Oncology2006，，11： | 1 |
| 18 | Sequential surgical resection of hepatic and pulmonary metastases from colorectal cancer显示文摘 | Stefan Limmer Elisabeth Oevermann Claudia Killaitis Peter Kujath Martin Hoffmann Hans-Peter Bruch | 2010 | Langenbeck’s Archives of Surgery2010，，8： | 1 |
| 19 | Analysis of Positron Lifetime Spectra Using Quantified Maximum Entropyand A general Linear Filter显示文摘 | Shukla A Peter M Hoffmann L | 1993 | Nucl Instrum Methods A1993，335，： | 1 |
| 20 | Magnetic Resonance Imaging–Guided Focused Ultrasound Treatment of Symptomatic Uterine Fibroids: Impact of Technology Advancement on Ablation Volumes in 115 Patients显示文摘 | Christoph G. Trumm Robert Stahl Dirk-André Clevert Peter Herzog Irene Mindjuk Sabine Kornprobst Christina Schwarz Ralf-Thorsten Hoffmann Maximilian F. Reiser Matthias Matzko | 2013 | Investigative Radiology2013，，： | 1 |
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