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| 1 | Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells显示文摘The miR-15/107 family comprises a group of 10 paralogous microRNAs(miRNAs),sharing a 50AGCAGC sequence.These miRNAs have overlapping targets.In order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members,and other selected miRNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal muscle.miR-103,miR-195 and miR-497 were expressed at similar levels across various tissues,whereas miR-107 is enriched in brain samples.We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations(enriched for cortical neurons,astrocytes and microglia,respectively).In primary cultures of rat brain cells,several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system(CNS).In addition to mature miRNAs,we also examined the expression of precursors(pri-miRNAs).Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors.In summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes. | Wang-Xia Wang Robert J.Danaher Craig S.Miller Joseph R.Berger Vega G.Nubia Bernard S.Wilfred Janna H.Neltner Christopher M.Norris Peter T.Nelson | 2014 | Genomics, Proteomics & Bioinformatics2014，12，1： | 9 |
| 2 | Risk factors for complications after ERCP: a multivariate analysis of 11,497 procedures over 12 years显示文摘 | Peter B. Cotton Donald A. Garrow Joseph Gallagher Joseph Romagnuolo | 2009 | Gastrointestinal Endoscopy2009，，1： | 7 |
| 3 | Ileal-anal pouches: A review of its history, indications, and complications显示文摘The ileal pouch anal anastomosis(IPAA)has revolutionised the surgical management of ulcerative colitis(UC)and familial adenomatous polyposis(FAP).Despite refinement in surgical technique(s)and patient selection,IPAA can be associated with significant morbidity.As the IPAA celebrated its 40th anniversary in 2018,this review provides a timely outline of its history,indications,and complications.IPAA has undergone significant modification since 1978.For both UC and FAP,IPAA surgery aims to definitively cure disease and prevent malignant degeneration,while providing adequate continence and avoiding a permanent stoma.The majority of patients experience long-term success,but“early”and“late”complications are recognised.Pelvic sepsis is a common early complication with far-reaching consequences of long-term pouch dysfunction,but prompt intervention(either radiological or surgical)reduces the risk of pouch failure.Even in the absence of sepsis,pouch dysfunction is a longterm complication that may have a myriad of causes.Pouchitis is a common cause that remains incompletely understood and difficult to manage at times.10%of patients succumb to the diagnosis of pouch failure,which is traditionally associated with the need for pouch excision.This review provides a timely outline of the history,indications,and complications associated with IPAA.Patient selection remains key,and contraindications exist for this surgery.A structured management plan is vital to the successful management of complications following pouch surgery. | Kheng-Seong Ng Simon Joseph Gonsalves Peter Michael Sagar | 2019 | World Journal of Gastroenterology2019，25，31： | 6 |
| 4 | Effect of Tangnaikang on TGF-β_1-induced transdifferentiation of human renal tubular epithelial HK-2 cells显示文摘OBJECTIVE: To explore the function of Tangnaikang (TNK) in the prevention and treatment of renal interstitial fibrosis through transdifferentiation of the human renal tubular epithelial cell line HK-2 induced by transforming growth factor-β1(TGF-β1).METHODS: HK-2 cells cultured in dulbecco's modified eagle medium/F12 (1∶1) with 10% fetal calf serum were divided into six groups: blank control group, TGF-β1 group (TGF-β1 10 ng/mL), serum control group (TGF-β1 10 ng/mL+10% serum), treatment group 1 (TGF-β1 10 ng/mL+ 5% TNK serum),treatment group 2 (TGF-β1 10 ng/mL+10% TNK serum), and treatment group 3 (TGF-β1 10 ng/mL+20% TNK serum). Cell proliferation was detected by 4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Expression of α-smooth muscle actin (α-SMA) and E-cadherin were observed by immunohistochemical assay. The contents of collagen Ⅰ (Col Ⅰ), collagen Ⅲ (Col Ⅲ), and fibronectin (FN) in the culture medium supernatant were detected by ELISA.RESULTS: E-cadherin was expressed and α-SMA was not expressed in normal HK-2 cells. In HK-2 cells cultured with TGF-β1,α-SMA expression significantly increased, HK-2 cells significantly proliferated, and secretion of Col Ⅰ, Col Ⅲ, and FN significantly increased compared with the blank control group (all P<0.05). In the HK-2 cells cultured with TGF-β1 and TNK serum, the expression of α-SMA significantly decreased, the expression of E-cadherin significantly increased, and the cell proliferation and the secretion of Col Ⅰ, Col Ⅲ and FN were significantly inhibited compared with the TGF-β1 group (all P<0.05).CONCLUSION: TNK can inhibit cell proliferation and reduce secretion of Col Ⅰ, Col Ⅲ, and FN.This indicates that TNK can inhibit transdifferentiation of human renal tubular epithelial cells induced by TGF-β1, with the effect of preventing and treating renal interstitial fibrosis. | Lixia Yang Xinhuan Ma Tao Cheng Tonghua Liu Lili Wu Wen Sun Margetts Peter Joseph | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 5 |
| 5 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 6 | Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design显示文摘 | Matthew H. G. Katz Robert Marsh Joseph M. Herman Qian Shi Eric Collison Alan P. Venook Hedy L. Kindler Steven R. Alberts Philip Philip Andrew M. Lowy Peter W. T. Pisters Mitchell C. Posner Jordan D. Berlin Syed A. Ahmad | 2013 | Annals of Surgical Oncology2013，，8： | 4 |
| 7 | 止消通脉宁干预转化生长因子-β_1诱导人肾小管上皮细胞表型转化的研究显示文摘目的观察止消通脉宁药物血清对转化生长因子-β1(TGF-β1)诱导人肾小管上皮细胞(HK-2)表型转化的影响,并探讨其机制。方法将HK-2细胞用含10%胎牛血清的DMEM/F12(1∶1)培养基培养并分为空白对照组、TGF-β1诱导组(TGF-β110 ng/mL)、空白血清对照组(TGF-β110 ng/mL+10%空白血清)、干预1组(TGF-β110 ng/mL+10%低剂量止消通脉宁药物血清)、干预2组(TGF-β110 ng/mL+10%中剂量止消通脉宁药物血清)、干预3组(TGF-β110 ng/mL+10%高剂量止消通脉宁药物血清)。药物干预24 h后,免疫组化检测α-平滑肌肌动蛋白(α-SMA)和E-钙黏蛋白(E-cadherin)的表达。在24、48、72 h应用酶联免疫吸附法检测细胞培养上清中Ⅰ型胶原(ColⅠ)、Ⅲ型胶原(ColⅢ)和纤连蛋白(FN)的含量。结果正常HK-2细胞表达E-cadherin,不表达α-SMA,经TGF-β1刺激后细胞表型发生转变,E-cadherin的表达明显减弱,α-SMA表达明显增强,且ColⅠ、ColⅢ和FN的分泌明显增加,与空白对照组比较差异有统计学意义(P<0.05)。止消通脉宁药物血清干预后α-SMA表达明显减弱,E-cadherin表达明显增强;同时抑制了ColⅠ、ColⅢ和FN的分泌,与TGF-β1诱导组比较差异有统计学意义(P<0.05)。结论止消通脉宁在一定程度上能够抑制人肾小管上皮细胞表型转化,减少细胞外基质成分的分泌,具有防治肾间质纤维化的作用。 | 杨丽霞 李晓东 程涛 刘铜华 吴丽丽 Margetts Peter Joseph | 2013 | 中国中医药信息杂志2013，20，1： | 4 |
| 8 | 2010-2015年全球实验室网络支持的消除麻疹和风疹工作的进展显示文摘2012年,世界卫生大会(World Health Assembly)签署全球疫苗行动计划(Global Vaccine Action Plan,GVAP),该计划旨在2020年前消除世界卫生组织(World Health Qrganization,WHO)5个区域的麻疹和风疹。2013年9月,WHO 6个区域的所有国家都已确立消除麻疹的目标,其中3个区域还确立了消除风疹和先天性风疹综合征的目标. | mick n.mulders paul a.rota joseph p.icenogle kevin e.brown makoto takeda gloria j.rey myriam c.ben mamou annick r.g.a.dosseh charles r.byabamazima hinda j.ahmed sirima pattamadilok yan zhang marta gacic-dobo peter m.strebel james l.goodson 周惠嘉(翻译) | 2018 | 上海预防医学2018，30，2： | 4 |
| 9 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 10 | A lexicon for endoscopic adverse events: report of an ASGE workshop显示文摘 | Peter B. Cotton Glenn M. Eisen Lars Aabakken Todd H. Baron Matt M. Hutter Brian C. Jacobson Klaus Mergener Albert Nemcek Bret T. Petersen John L. Petrini Irving M. Pike Linda Rabeneck Joseph Romagnuolo John J. Vargo | 2010 | Gastrointestinal Endoscopy2010，，3： | 3 |
| 11 | Consensus Panel Recommendation for Incorporating Lipoprotein-Associated Phospholipase A 2 Testing into Cardiovascular Disease Risk Assessment Guidelines显示文摘 | Michael H. Davidson Marshall A. Corson Mark J. Alberts Jeffrey L. Anderson Philip B. Gorelick Peter H. Jones Amir Lerman Joseph P. McConnell Howard S. Weintraub | 2008 | The American Journal of Cardiology2008，，12： | 3 |
| 12 | 止消通脉宁干预TGF-β_1诱导HK-2细胞增殖的研究显示文摘目的:通过观察止消通脉宁含药血清对转化生长因子-β1(TGF-β1)诱导人肾小管上皮细胞(HK-2)增殖的影响,探讨治疗糖尿病肾病有效中药复方止消通脉宁在防治肾间质纤维化方面的作用。方法:将HK-2细胞用含10%胎牛血清的DMEM/F12(1∶1)培养基培养;实验分为6组:空白对照组、单纯TGF-β1诱导组(TGF-β110ng/mL)、空白血清对照组(TGF-β110 ng/mL+10%空白血清)、干预1组(TGF-β110 ng/mL+10%低剂量止消通脉宁含药血清)、干预2组(TGF-β110 ng/mL+10%中剂量止消通脉宁含药血清)、干预3组(TGF-β110 ng/mL+10%高剂量止消通脉宁含药血清)。倒置显微镜下观察各组细胞形态,MTT法检测细胞增殖。结果:TGF-β110 ng/mL能显著诱导人肾小管上皮细胞增殖,与空白对照组相比有显著性差异(P<0.05),且其作用随处理时间的延长而增强,但和止消通脉宁含药血清共同作用后,其促细胞增殖作用受到一定抑制(P<0.05)。结论:止消通脉宁能抑制HK-2细胞增殖,在一定程度上具有防治肾间质纤维化的作用。 | 任虹 杨丽霞 吴丽丽 刘铜华 Margetts Peter Joseph | 2012 | 西部中医药2012，25，8： | 3 |
| 13 | Synthesis and Application of Granular Activated Carbon from Biomass Waste Materials for Water Treatment:A Review显示文摘There is an increased global demand for activated carbon(AC)in application of water treatment and purification.Water pollutants that have exhibited a greater removal efficiency by AC included but not limited to heavy metals,pharmaceuticals,pesticides,natural organic matter,disinfection by-products,and microplastics.Granular activated carbon(GAC)is mostly used in aqueous so-lutions and adsorption columns for water treatment.Commercial AC is not only costly,but also obtained from non-renewable sources.This has prompted the search for alternative renewable materials for AC production.Biomass wastes present a great potential of such materials because of their availability and carbonaceous nature.This in turn can reduce on the adverse environmental effects caused by poor disposal of these wastes.The challenges associated with biomass waste based GAC are their low strength and attrition resistance which make them easily disintegrate under aqueous phase.This paper provides a comprehensive review on recent advances in production of biomass waste based GAC for water treatment and highlights future research directions.Production parameters such as granulation conditions,use of binders,carbonization,activation methods,and their effect on textural properties are discussed.Factors influencing the adsorption capacities of the derived GACs,adsorption models,adsorption mechanisms,and their regeneration potentials are reviewed.The literature reveals that biomass waste materials can produce GAC for use in water treatment with possibilities of being regenerated.Nonetheless,there is a need to explore 1)the effect of preparation pathways on the adsorptive properties of biomass derived GAC,2)sustainable production of biomass derived GAC based on life cycle assessment and techno-economic analysis,and 3)adsorption mechanisms of GAC for removal of contaminants of emerging concerns such as microplastics and unregulated disinfection by-products. | Joseph Jjagwe Peter Wilberforce Olupot Emmanuel Menya Herbert Mpagi Kalibbala | 2021 | Journal of Bioresources and Bioproducts2021，6，4： | 3 |
| 14 | Fungal diversity notes 367-490:taxonomic and phylogenetic contributions to fungal taxa显示文摘This is a continuity of a series of taxonomic papers where materials are examined,described and novel combinations are proposed where necessary to improve our traditional species concepts and provide updates on their classification.In addition to extensive morphological descriptions and appropriate asexual and sexual connections,DNA sequence data are also analysed from concatenated datasets(rDNA,TEF-a,RBP2 and b-Tubulin)to infer phylogenetic relationships and substantiate systematic position of taxa within appropriate ranks.Wherever new species or combinations are being proposed,we apply an integrative approach(morphological and molecular data as well as ecological features wherever applicable).Notes on 125 fungal taxa are compiled in this paper,including eight new genera,101 new species,two new combinations,one neotype,four reference specimens,new host or distribution records for eight species and one alternative morphs.The new genera introduced in this paper are Alloarthopyrenia,Arundellina,Camarosporioides,Neomassaria,Neomassarina,Neotruncatella,Paracapsulospora and Pseudophaeosphaeria.The new species are Alfaria spartii,Alloarthopyrenia italica,Anthostomella ravenna,An.thailandica,Arthrinium paraphaeospermum,Arundellina typhae,Aspergillus koreanus,Asterina cynometrae,Bertiella ellipsoidea,Blastophorum aquaticum,Cainia globosa,Camarosporioides phragmitis,Ceramothyrium menglunense,Chaetosphaeronema achilleae,Chlamydotubeufia helicospora,Ciliochorella phanericola,Clavulinopsis aurantiaca,Colletotrichum insertae,Comoclathris italica,Coronophora myricoides,Cortinarius fulvescentoideus,Co.nymphatus,Co.pseudobulliardioides,Co.tenuifulvescens,Cunninghamella gigacellularis,Cyathus pyristriatus,Cytospora cotini,Dematiopleospora alliariae,De.cirsii,Diaporthe aseana,Di.garethjonesii,Distoseptispora multiseptata,Dis.tectonae,Dis.tectonigena,Dothiora buxi,Emericellopsis persica,Gloniopsis calami,Helicoma guttulatum,Helvella floriforma,H.oblongispora,Hermatomyces subiculosa,Juncaceicola italica,Lactarius dirkii,Lentithecium unicellulare,Le.voraginesporum,Leptosphaeria cirsii,Leptosphaeria irregularis,Leptospora galii,Le.thailandica,Lindgomyces pseudomadisonensis,Lophiotrema bambusae,Lo.fallopiae,Meliola citri-maximae,Minimelanolocus submersus,Montagnula cirsii,Mortierella fluviae,Muriphaeosphaeria ambrosiae,Neodidymelliopsis ranunculi,Neomassaria fabacearum,Neomassarina thailandica,Neomicrosphaeropsis cytisi,Neo.cytisinus,Neo.minima,Neopestalotiopsis cocoe¨s,Neopestalotiopsis musae,Neoroussoella lenispora,Neotorula submersa,Neotruncatella endophytica,Nodulosphaeria italica,Occultibambusa aquatica,Oc.chiangraiensis,Ophiocordyceps hemisphaerica,Op.lacrimoidis,Paracapsulospora metroxyli,Pestalotiopsis sequoiae,Peziza fruticosa,Pleurotrema thailandica,Poaceicola arundinis,Polyporus mangshanensis,Pseudocoleophoma typhicola,Pseudodictyosporium thailandica,Pseudophaeosphaeria rubi,Purpureocillium sodanum,Ramariopsis atlantica,Rhodocybe griseoaurantia,Rh.indica,Rh.luteobrunnea,Russula indoalba,Ru.pseudoamoenicolor,Sporidesmium aquaticivaginatum,Sp.olivaceoconidium,Sp.pyriformatum,Stagonospora forlicesenensis,Stagonosporopsis centaureae,Terriera thailandica,Tremateia arundicola,Tr.guiyangensis,Trichomerium bambusae,Tubeufia hyalospora,Tu.roseohelicospora and Wojnowicia italica.New combinations are given for Hermatomyces mirum and Pallidocercospora thailandica.A neotype is proposed for Cortinarius fulvescens.Reference specimens are given for Aquaphila albicans,Leptospora rubella,Platychora ulmi and Meliola pseudosasae,while new host or distribution records are provided for Diaporthe eres,Di.siamensis,Di.foeniculina,Dothiorella iranica,Do.sarmentorum,Do.vidmadera,Helvella tinta and Vaginatispora fuckelii,with full taxonomic details.An asexual state is also reported for the first time in Neoacanthostigma septoconstrictum.This paper contributes to a more comprehensive update and improved identification of many ascomycetes and basiodiomycetes. | Kevin D.Hyde Sinang Hongsanan Rajesh Jeewon D.Jayarama Bhat Eric H.C.McKenzie E.B.Gareth Jones Rungtiwa Phookamsak Hiran A.Ariyawansa Saranyaphat Boonmee Qi Zhao Faten Awad Abdel-Aziz Mohamed A.Abdel-Wahab Supharat Banmai Putarak Chomnunti Bao-Kai Cui Dinushani A.Daranagama Kanad Das Monika C.Dayarathne Nimali Ide Silva Asha J.Dissanayake Mingkwan Doilom Anusha H.Ekanayaka Tatiana Baptista Gibertoni Aristóteles Góes-Neto Shi-Ke Huang Subashini C.Jayasiri Ruvishika S.Jayawardena Sirinapa Konta Hyang Burm Lee Wen-Jing Li Chuan-Gen Lin Jian-Kui Liu Yong-Zhong Lu Zong-Long Luo Ishara S.Manawasinghe Patinjareveettil Manimohan Ausana Mapook Tuula Niskanen Chada Norphanphoun Moslem Papizadeh Rekhani H.Perera Chayanard Phukhamsakda Christian Richter AndréL.C.Mde A.Santiago E.Ricardo Drechsler-Santos Indunil C.Senanayake Kazuaki Tanaka T.M.D.S.Tennakoon Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Benjarong Thongbai Alfredo Vizzini Dhanushka N.Wanasinghe Nalin N.Wijayawardene Hai-Xia Wu Jing Yang Xiang-Yu Zeng Huang Zhang Jin-Feng Zhang Timur S.Bulgakov Erio Camporesi Ali H.Bahkali Mohammad A.Amoozegar Lidia Silva Araujo-Neta Joseph F.Ammirati Abhishek Baghela R.P.Bhatt Dimitar Bojantchev Bart Buyck Gladstone Alves da Silva Catarina Letícia Ferreira de Lima Rafael JoséVilela de Oliveira Carlos Alberto Fragoso de Souza Yu-Cheng Dai Bálint Dima Tham Thi Duong Enrico Ercole Fernando Mafalda-Freire Aniket Ghosh Akira Hashimoto Sutakorn Kamolhan Ji-Chuan Kang Samantha C.Karunarathna Paul M.Kirk Ilkka Kytovuori Angela Lantieri Kare Liimatainen Zuo-Yi Liu Xing-Zhong Liu Robert Lücking Gianfranco Medardi Peter E.Mortimer Thi Thuong Thuong Nguyen Itthayakorn Promputtha K.N.Anil Raj Mateus A.Reck Saisamorn Lumyong Seyed Abolhassan Shahzadeh-Fazeli Marc Stadler Mohammad Reza Soudi Hong-Yan Su Takumasa Takahashi Narumon Tangthirasunun Priyanka Uniyal Yong Wang Ting-Chi Wen Jian-Chu Xu Zhong-Kai Zhang Yong-Chang Zhao Jun-Liang Zhou Lin Zhu | 2016 | Fungal Diversity2016，，5： | 2 |
| 15 | Preoperative Nutritional Status Is an Important Predictor of Survival in Patients Undergoing Surgery for Renal Cell Carcinoma显示文摘 | Todd M. Morgan Dominic Tang Kelly L. Stratton Daniel A. Barocas Christopher B. Anderson Justin R. Gregg Sam S. Chang Michael S. Cookson S. Duke Herrell Joseph A. Smith Peter E. Clark | 2011 | European Urology2011，，6： | 2 |
| 16 | Biodiversity, Nitrogen Deposition, and CO2 Affect Grassland Soil Carbon Cycling but not Storage显示文摘 | Joseph Reid E. Adair Sarah Hobbie Peter Reich | 2012 | Ecosystems2012，，4： | 2 |
| 17 | Long-Term Outcomes for Patients with Post–Liver Transplant Anastomotic Biliary Strictures Treated by Endoscopic Stent Placement显示文摘 | Joseph Morelli Hugh E Mulcahy Ira R Willner John T Cunningham Peter Draganov | 2003 | Gastrointestinal Endoscopy2003，，3： | 2 |
| 18 | 止消通脉宁对TGF-β_1诱导的人肾小管上皮细胞CTGF、PAI-1、MMP-9 mRNA表达的影响显示文摘目的观察止消通脉宁药物血清(以下简称'药物血清')清干预转化生长因子-β1(TGF-β1)诱导的人肾小管上皮细胞(HK-2)结缔组织生长因子(CTGF)、纤溶酶原激活物抑制物-1(PAI-1)、基质金属蛋白酶-9(MMP-9)mRNA的表达,探讨其在防治肾间质纤维化方面的作用。方法将HK-2细胞用含10%胎牛血清的DMEM/F12(1∶1)培养基培养。实验分为空白对照组、单纯TGF-β1诱导组(TGF-β110 ng/mL)、空白血清对照组(TGF-β110 ng/mL+10%空白血清)、干预1组(TGF-β110 ng/mL+10%低剂量药物血清)、干预2组(TGF-β110 ng/mL+10%中剂量药物血清)、干预3组(TGF-β110 ng/mL+10%高剂量药物血清)。药物干预24 h后,荧光定量PCR检测CTGF、PAI-1和MMP-9 mRNA的表达。结果 HK-2细胞经TGF-β1诱导后,CTGF、PAI-1 mRNA表达显著上升,MMP-9 mRNA表达减弱,与空白对照组比较差异有统计学意义(P<0.05)。经止消通脉宁药物血清干预后,CTGF、PAI-1 mRNA表达逐步下降,MMP-9 mRNA表达逐步上升,与单纯TGF-β1诱导组比较差异有统计学意义(P<0.05)。结论止消通脉宁在一定程度上能够抑制TGF-β1诱导的人肾小管上皮细胞纤维化,其机制可能与调节纤维化细胞因子CTGF、PAI-1和MMP-9的mRNA表达有关。 | 马新换 颜春鲁 杨丽霞 张邦能 刘铜华 吴丽丽 Margetts Peter Joseph | 2013 | 中国中医药信息杂志2013，20，3： | 2 |
| 19 | Dual-energy CT of the heart—Principles and protocols显示文摘 | Florian Schwarz Balazs Ruzsics U. Joseph Schoepf Gorka Bastarrika Salvatore A. Chiaramida Joseph A. Abro Robin L. Brothers Sebastian Vogt Bernhard Schmidt Philip Costello Peter L. Zwerner | 2008 | European Journal of Radiology2008，，3： | 2 |
| 20 | Ureteroscopy: Current Practice and Long-Term Complications显示文摘 | William J. Harmon Peter D. Sershon Michael L. Blute David E. Patterson Joseph W. Segura | 1997 | The Journal of Urology1997，，1： | 2 |
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