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| 1 | Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis显示文摘AIM: To determine the eff icacy of tacrolimus on clinical status, histopathological status and biochemical markers in patients with steroid refractory autoimmune hepatitis (AIH). METHODS: Retrospectively, clinical parameters, biochemistry and histology were obtained from patient records. RESULTS: Nine patients [8 females/1 male, median age 32 (range 16-64) years] were identified to have received tacrolimus for a median duration of 18 (12-37) mo. Before initiation of tacrolimus treatment the patients were maintained on a prednisolone dose of 20 mg daily (range 20-80 mg/d), which was tapered to 7.5 (5-12.5) mg/d (P = 0.004). Alanine aminotransferase and immunoglobulin-G concentrations decreased from 154 (100-475) to 47(22-61) U/L (P = 0.007), and from 16 (10-30.2) to 14.5 (8.4-20) g/L (P = 0.032), respectively. All patients showed improvement of the liver inflammatory activity, as determined by the Ishak score (P = 0.016), while the degree of f ibrosis tended to decrease (P = 0.049). CONCLUSION: The use of low dose tacrolimus can lead to biochemical and histologic improvement of inflammation with no progression of the stage of f ibrosis in patients with steroid refractory AIH. Low dose tacrolimus therapy also allows substantial reduction of prednisone dose. | Fin Stolze Larsen Ben Vainer Martin Eefsen Peter Nissen Bjerring Bent Adel Hansen | 2007 | World Journal of Gastroenterology2007，13，23： | 15 |
| 2 | Vibriofischeri显示文摘 | Antje Brack J irgen Strube Peter Stolz | | 0，，03： | 1 |
| 3 | The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema显示文摘 | Peter Nissen Bjerring Martin Eefsen Bent Adel Hansen Fin Stolze Larsen | 2009 | Metabolic Brain Disease2009，，1： | 1 |
| 4 | Cerebral oxygenation determined by near-infrared spectrophotometry in patients with fulminant hepatic failure显示文摘 | Henning Bay Nielsen Flemming Tofteng Lars Peter Wang Fin Stolze Larsen | 2002 | Journal of Hepatology2002，，2： | 1 |
| 5 | Cerebral microdialysis in patients with fulminant hepatic failure显示文摘 | Flemming Tofteng Linda Jorgensen Bent Adel Hansen Peter Ott Jens Kondrup Fin Stolze Larsen | 2002 | Hepatology2002，，6： | 1 |
| 6 | Metabolic Ensinecring of Corynebacterium glutamicum for L - Serine Production 显示文摘 | Petra Peters - Wcndisch Michael Stolz Hclga Ettcrich | 2005 | Applied and Environmental Microbiology2005，71，： | 1 |
| 7 | Blood–brain barrier permeability to ammonia in liver failure: a critical reappraisal显示文摘 | Peter Ott Fin Stolze Larsen | 2003 | Neurochemistry International2003，，4： | 1 |
| 8 | Vibrio fischeri 显示文摘 | Antic Brack Jtlrgen Strube Peter Stolz | 2003 | Biochimica et Biophysica Acta (BBA) - General Subjects2003，1621，3： | 1 |
| 9 | Sildenafil does not influence hepatic venous pressure gradient in patients with cirrhosis显示文摘AIM: To investigate if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient (HVPG) in patients with cirrhosis.Phosphodiesterase type-5 inhibitors are valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stage liver disease.However,the effect of phosphodiesterase type-5 inhibitors on splanchnic blood flow and portal hypertension remains essentially unknown.METHODS: Ten patients with biopsy proven cirrhosis (five females/five males,mean age 54 ± 8 years) and an HVPG above 12 mmHg were studied after informed consent.Measurement of splanchnic blood flow and the HVPG during liver vein catheterization were done before and 80 min after oral administration of 50 mg sildenafil.Blood flow was estimated by use of indocyanine green clearance technique and Fick's principle,with correction for non-steady state.RESULTS: The plasma concentration of sildenafil was 222 ± 136 ng/mL 80 min after administration.Mean arterial blood pressure decreased from 77 ± 7 mmHg to 66 ± 12 mmHg,P = 0.003,while the splanchnic blood flow and oxygen consumption remained unchanged at 1.14 ± 0.71 L/min and 2.3 ± 0.6 mmol/ min,respectively.Also the HVPG remained unchanged (18 ± 2 mmHg vs 16 ± 2 mmHg) with individual changes ranging from -8 mmHg to +2 mmHg.In seven patients,HVPG decreased and in three it increased.CONCLUSION: In spite of arterial blood pressure decreases 80 min after administration of the phosphodiesterase type-5 inhibitor sildenafil,the present study could not demonstrate any clinical relevant influence on splanichnic blood flow,oxygen consumption or the HVPG. | Jens Otto Clemmesen Annamaria Giraldi Peter Ott Kim Dalhoff Bent Adel Hansen Fin Stolze Larsen | 2008 | World Journal of Gastroenterology2008，14，40： | 1 |
| 10 | Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure显示文摘 | Peter Nissen Bjerring John Hauerberg Linda J?rgensen Hans-J?rgen Frederiksen Flemming Tofteng Bent Adel Hansen Fin Stolze Larsen | 2010 | Journal of Hepatology2010，，6： | 1 |
| 11 | Cerebral Glutamine Concentration and Lactate–Pyruvate Ratio in Patients with Acute Liver Failure显示文摘 | Peter Nissen Bjerring John Hauerberg Hans-Jorgen Frederiksen Linda Jorgensen Bent Adel Hansen Flemming Tofteng Fin Stolze Larsen | 2008 | Neurocritical Care2008，，1： | 1 |
| 12 | Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia显示文摘AIM:To investigate the neuroprotective potential of ciclosporin during acute liver failure. We evaluated the effect of intrathecally administered ciclosporin on intracranial pressure, brain water content and aquaporin-4 expression in a rat model with acute hyperammonaemia.METHODS:Twenty-four male Wistar rats with portacaval anastomosis were randomised into four groups receiving ciclosporin or vehicle and ammonia or saline infusion. Ciclosporin or vehicle was given intrathecally prior to the ammonia or saline infusion. The ammonia or saline infusion was given intravenously for 4 h,while intracranial pressure and arterial pressure was recorded. At the end of the experiment, cerebral cortex and cerebellar brain tissue was analysed for water and aquaporin-4 content.RESULTS:The following intracranial pressures were found at the end of the experiment:ammonia + ciclosporin:10.0±1.7 mmHg, ammonia + vehicle:6.8±1.0mmHg, saline + ciclosporin:3.1±0.5 mmHg, saline +vehicle:3.3 ± 0.6 mmHg. Ammonia infusion had a significant effect on intracranial pressure and brain water content, which both were higher in the groups receiving ammonia(P<0.001, two-way analysis of variance). Treatment with ciclosporin resulted in relevant tissue concentrations of ciclosporin(>0.2 micromolar)but did not reduce intracranial pressure after 4 h. Furthermore, ciclosporin did not attenuate the increase in cerebral water content, and did not affect aquaporin-4expression.CONCLUSION:Intrathecal administration of ciclosporin does not attenuate intracranial hypertension or brain oedema in rats with portacaval anastomosis and 4 h of ammonia infusion. | Rikke Hebo Larsen Mette S Kjr Martin Eefsen Fin Stolze Larsen Peter Nissen Bjerring | 2013 | World Journal of Hepatology2013，5，9： | 0 |
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