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| 1 | Adverse events with bismuth salts for Helicobacter pylori eradication:Systematic review and meta-analysis显示文摘AIM: To assess the safety of bismuth used in Helico- bacter pylori (H pylori) eradication therapy regimens. METHODS: We conducted a systematic review and meta-analysis. MEDLINE and EMBASE were searched (up to October 2007) to identify randomised controlled tri- als comparing bismuth with placebo or no treatment, or bismuth salts in combination with antibiotics as part of eradication therapy with the same dose and duration of antibiotics alone or, in combination, with acid suppres- sion. Total numbers of adverse events were recorded. Data were pooled and expressed as relative risks with 95% confidence intervals (CI). RESULTS: We identified 35 randomised controlled tri- als containing 4763 patients. There were no serious adverse events occurring with bismuth therapy. There was no statistically significant difference detected in total adverse events with bismuth [relative risk (RR) = 1.01; 95% CI: 0.87-1.16], specific individual adverse events, with the exception of dark stools (RR = 5.06; 95% CI: 1.59-16.12), or adverse events leading to withdrawal of therapy (RR = 0.86; 95% CI: 0.54-1.37). CONCLUSION: Bismuth for the treatment of H pylori is safe and well-tolerated. The only adverse event oc- curring significantly more commonly was dark stools. | Alexander C Ford Peter Malfertheiner Monique Giguère José Santana Mostafizur Khan Paul Moayyedi | 2008 | World Journal of Gastroenterology2008，14，48： | 62 |
| 2 | Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses:A multicenter study显示文摘AIM:To evaluate the ability of endoscopic ultrasound(EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes.METHODS:A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass(n=121) or lymph node(n=101).The classification as benign or malignant,based on the real time elastography pattern,was compared with the classif ication based on the B-mode EUS images and with the fi nal diagnosis obtained by EUS-guided fi ne needle aspiration(EUS-FNA) and/or by surgical pathology.An interobserver study was performed.RESULTS:The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%,respectively,compared to 92.3% and 68.9%,respectively,for the conventional B-mode images.The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%,respectively,compared to 78.6% and 50.0%,respectively,for the B-mode images.The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes.CONCLUSION:EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity,specificity and accuracy.It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes. | Marc Giovannini Botelberge Thomas Bories Erwan Pesenti Christian Caillol Fabrice Esterni Benjamin Monges Geneviève Arcidiacono Paolo Deprez Pierre Yeung Robert Schimdt Walter Schrader Hanz Szymanski Carl Dietrich Christoph Eisendrath Pierre Van Laethem Jean-Luc Devière Jacques Vilmann Peter Saftoiu Andrian | 2009 | World Journal of Gastroenterology2009，15，13： | 48 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 4 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 5 | Long term effects of infant pain 显示文摘 | Grunau RE Holsti L Peters JWB | 2006 | Sem Fetal Neonatal Med2006，11，： | 1 |
| 6 | Somatostatin-like receptors in goldfish:cloning of four new receptors显示文摘 | Lin X Peter RE | 2003 | Peptides2003，24，1： | 1 |
| 7 | Molecular basis of endothelial dysfunction in sepsis 显示文摘 | Peters K Unger RE Brunner J | 2003 | Cardiovasc Res2003，15，1： | 1 |
| 8 | Neonatal Facial Coding System for assessing postoperative pain in infants: item reduction is valid and feasible显示文摘 | Peters JW Koot HM Grunau RE | 2003 | Clin J Pain2003，19，6： | 1 |
| 9 | Randomized trial on endoscopic resection-cap versus multiband mucosectomy for piecemeal endoscopic resection of early Barretts neoplasia显示文摘 | Pouw RE van Vilsteren FG Peters FP | 2011 | Gastrointest Endosc2011，74，1： | 1 |
| 10 | Association between expression of activated 72 kilodalton gelatinase and tumor spreed in non-small lung camcer显示文摘 | Peter BD Bloxide RE Start NS | 1993 | Jnatl Cancer Inst1993，85，7： | 1 |
| 11 | Effects of food deprivation and refeeding on neuropeptide Y (NPY) mRNA levels in goldfish 显示文摘 | Narnaware YK Peter RE | 2001 | Comparative Biochemistry and Physiology2001，129，： | 1 |
| 12 | Growth of human cells on a nonwoven silk fibroin net: a potential for use in tissue engineering显示文摘 | Unger RE Wolf M Peters K | 2004 | Biomatefials2004，25，： | 1 |
| 13 | Long-term consequences of pain in human neonates 显示文摘 | Grunau RE Holsti L Peters JW | 2006 | Semin Fetal Neonatal Med2006，11，4： | 1 |
| 14 | Stimulation of feeding behavior and food consumption in the goldfish,carassius auratus,by orexin-A and orexin-B显示文摘 | Volkoff H Bjorklund JM Peter RE | 1999 | Brain Res1999，846，： | 1 |
| 15 | Influencc of age,sex,and strength training on human muscle gene expression deferminde by microarray显示文摘 | Roth SM Ferrell RE Peters DG | 2002 | Physiol Genomics2002，10，： | 1 |
| 16 | Does glyceryl nitrate prevent post-ERCP pancreatitis? A prospective, randomized, double-blind, placebo-controlled multicenter trial显示文摘 | Camilla N?jgaard Mads Hornum Margarita Elkjaer Claes Hjalmarsson Laurent Heyries Truls Hauge K?re Bakkevold Per Kragh Andersen Peter Matzen | 2009 | Gastrointestinal Endoscopy2009，，6： | 1 |
| 17 | Long-tern1 consequences of pain in human neonates 显示文摘 | Grunau RE Holsti I Peters jw | 2006 | Semin Fetal Neonatal Med2006，11，4： | 1 |
| 18 | Growth of human cells on a nonwoven silk fibroin net: a potential for use in tissuengineering显示文摘 | Unger RE Wolf M Peters K | 2004 | Biomaterials2004，25，6： | 1 |
| 19 | Neonatal Facial Coding System for assessing postoperative pain in infants:Item reduction is valid and feasible显示文摘 | Peter J W Koot HM G rtnan RE | 2003 | Clin J Pain2003，19，6： | 1 |
| 20 | Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial显示文摘 | Peter Malfertheiner Franco Bazzoli Jean-Charles Delchier Krysztof Celi?ski Monique Giguère Marc Rivière Francis Mégraud | 2011 | The Lancet2011，，9769： | 1 |
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