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| 1 | Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis显示文摘AIM: To investigate the relationship between osteopontin plasma concentrations and the severity of portal hypertension and to assess osteopontin prognostic value.METHODS: A cohort of 154 patients with confirmed liver cirrhosis(112 ethylic, 108 men, age 34-72 years)were enrolled in the study. Hepatic venous pressure gradient(HVPG) measurement and laboratory and ultrasound examinations were carried out for all patients. HVPG was measured using a standard catheterization method with the balloon wedge technique. Osteopontin was measured using the enzyme-linked immunosorbent assay(ELISA) method in plasma. Patients were followed up with a specific focus on mortality. The control group consisted of 137 healthy age- and sex- matched individuals.RESULTS: The mean value of HVPG was 16.18 ± 5.6 mm Hg. Compared to controls, the plasma levels of osteopontin in cirrhotic patients were significantly higher(P < 0.001). The plasma levels of osteopontin were positively related to HVPG(P = 0.0022, r = 0.25) and differed among the individual Child-Pugh groups of patients. The cut-off value of 80 ng/m L osteopontin distinguished patients with significant portal hypertension(HVPG above 10 mm Hg) at 75% sensitivity and 63% specificity. The mean follow-up of patients was 3.7 ± 2.6 years. The probability of cumulative survival was 39% for patients with HVPG > 10 mm Hg and 65% for those with HVPG ≤ 10 mm Hg(P = 0.0086, odds ratio(OR), 2.92, 95% confidence interval(CI): 1.09-7.76). Osteopontin showed a similar prognostic value to HVPG. Patients with osteopontin values above 80 ng/m L had significantly lower cumulative survival compared to those with osteopontin ≤ 80 ng/m L(37% vs 56%, P = 0.00035; OR = 2.23, 95%CI: 1.06-4.68).CONCLUSION: Osteopontin is a non-invasive parameter of portal hypertension that distinguishes patients with clinically significant portal hypertension. It is a strong prognostic factor for survival. | Radan Bruha Marie Jachymova Jaromir Petrtyl Karel Dvorak Martin Lenicek Petr Urbanek Tomislav Svestka Libor Vitek | 2016 | World Journal of Gastroenterology2016，22，12： | 20 |
| 2 | Probiotics in hepatology显示文摘The paper provides a basic review of intestinal micro- flora and its importance in liver diseases. The intestinal microflora has many important functions, above all to maintain the microbial barrier against established as well as potential pathogens. Furthermore, it influences the motility and perfusion of the intestinal wall, stimu- lates the intestinal immune system and therefore also the so-called common mucosal immune system, re- ducing bacterial translocation and producing vitamins. Immune homeostasis at mucosal level results from a controlled response to intestinal luminal antigens. In liver cirrhosis, there are many changes in its function, mostly an increase in bacterial overgrowth and trans- location. In this review, probiotics and their indications in hepatology are generally discussed. According to recent knowledge, these preparations are indicated in clinical practice only for cases of hepatic encephalopa- thy. Probiotics are able to decrease the permeability ofthe intestinal wall, and decrease bacterial translocation and endotoxemia in animal models as well as in clinical studies, which is extremely important in the prevention of complications of liver cirrhosis and infection after liv- er transplantation. Probiotics could limit oxidative and inflammatory liver damage and, in some situations, improve the histological state, and thus non-alcoholic steatohepatitis could be considered as another possible indication. ? 2011 Baishideng. All rights reserved. | Jan Lata Jana Jurankova Marcela Kopacova Petr Vitek | 2011 | World Journal of Gastroenterology2011，17，24： | 19 |
| 3 | Dietary habits of colorectal neoplasia patients in comparison to their first-degree relatives显示文摘AIM:To compare the dietary habits between colorectal neoplasia patients,their first-degree relatives,and unrelated controls.METHODS:From July 2008 to April 2011,we collected epidemiological data relevant to colorectal cancer from patients with colorectal neoplasias,their first-degree relatives,and also from a control group consisting of people referred for colonoscopy with a negative family history of colorectal cancer and without evidence of neoplasia after colonoscopic examination.The first-degree relatives were divided into two groups following the colonoscopic examination:(1)patients with neoplasia or(2)patients without neoplasia.Dietary habits of all groups were compared.Aχ2 test was used to assess the association between two dichotomous categorical variables.RESULTS:The study groups consisted of 242 patients with colorectal neoplasias(143 men,99 women;mean age:64±12 years)and 160 first-degree relatives(66men,94 women;mean age:48±11 years).Fifty-five of the first-degree relatives were found to have a neoplastic lesion upon colonoscopy,while the remaining105 were without neoplasia.The control group contained 123 individuals with a negative family history for neoplastic lesions(66 men,57 women;mean age:54±12 years).Two hypotheses were tested.In the first,the dietary habits of first-degree relatives with neoplasia were more similar to those of patients with neoplasia,while the dietary habits of first-degree relatives without neoplasia were similar to those of the control group.In the second,no sex-related differences in dietary habits were expected between the particular groups.Indeed,no significant differences were observed in the dietary habits between the groups of patients,controls and first-degree relatives with/without neoplastic lesions.Nevertheless,statistically significant sex-related differences were observed in all groups,wherein women had healthier dietary habits than men.CONCLUSION:In all groups examined,women had healthier dietary habits than men.Modification of screening guidelines according to sex may improve the efficiency of screening programs. | Ivana Mikoviny Kajzrlikova Petr Vitek Josef Chalupa Petr Dite | 2014 | World Journal of Gastroenterology2014，20，17： | 0 |
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