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| 1 | New targeted therapies in pancreatic cancer显示文摘Patients with pancreatic cancer have a poor prognosis with a median survival of 4-6 mo and a 5-year survival of less than 5%. Despite therapy with gemcitabine, patient survival does not exceed 6 mo, likely due to natural resistance to gemcitabine. Therefore, it is hoped that more favorable results can be obtained by using guided immunotherapy against molecular targets. This review summarizes the new leading targeted therapies in pancreatic cancers, focusing on passive and specific immunotherapies. Passive immunotherapy may have a role for treatment in combination with radiochemotherapy, which otherwise destroys the immune system along with tumor cells. It includes mainly therapies targeting against kinases, including epidermal growth factor receptor, Ras/Raf/mitogenactivated protein kinase cascade, human epidermal growth factor receptor 2, insulin growth factor-1 receptor, phosphoinositide 3-kinase/Akt/m TOR and hepatocyte growth factor receptor. Therapies against DNA repair genes, histone deacetylases, micro RNA, and pancreatic tumor tissue stromal elements(stromal extracellular matric and stromal pathways) are also discussed. Specific immunotherapies, such as vaccines(whole cell recombinant, peptide, and dendritic cell vaccines), adoptive cell therapy and immunotherapy targeting tumor stem cells, have the role of activating antitumor immune responses. In the future, treatments will likely include personalized medicine, tailored for numerous molecular therapeutic targets of multiple pathogenetic pathways. | Andrada Seicean Livia Petrusel Radu Seicean | 2015 | World Journal of Gastroenterology2015，21，20： | 12 |
| 2 | Fixed Points and Homotopy Results for Ciric-type Multivalued Operators on a Set with Two Metrics显示文摘 | Lazar T O'Regan D Petrusel A | | 0，，01： | 1 |
| 3 | Multivalued fractals in b-metric spaces显示文摘 | BORICEANU M BOTA M PETRUSEL A | 2010 | Cent Eur J Math2010，8，2： | 1 |
| 4 | Relationship between cachexia and perineural invasion in pancreatic adenocarcinoma显示文摘BACKGROUND Cachexia is responsible for the low quality of life in pancreatic adenocarcinoma(PDAC).The rapid disease progression and patient deterioration seems related to perineural invasion,but the relationship between cachexia and perineural invasion for the evolution of the disease has been rarely studied.As perineural invasion is difficult to be highlighted,a biomarker such as the neurotrophic factor Midkine(MK)which promotes the neuronal differentiation and the cell migration could be helpful.Also,Activin(ACV)has been described as cachexia related to PDAC.However,their role for assessing and predicting the disease course in daily practice is not known.AIM To assess the relationship between perineural invasion and cachexia and their biomarkers,MK and ACV,respectively,and their prognostic value.METHODS This study included prospectively enrolled patients with proven adenocarcinoma and a matched group of controls without any malignancies.Patients with other causes of malnutrition were excluded.The plasma levels of ACV and MK were analyzed using western blotting and were correlated with the clinicopathological features and survival data.These results were validated by immunohistochemical analyses of the pancreatic tumor tissue of the patients included in the study and a supplementary group of surgically resected specimens from patients with a benign disease.RESULTS The study comprised 114 patients with PDAC,125 controls and a supplementary group of 14 benign pancreatic tissue samples.ACV and MK were both overexpressed more frequently in the plasma of patients with PDAC than in the controls(63% vs 32% for ACV,P<0.001;47%vs 16%for MK,P<0.001),with similar levels in pancreatic tissue the MK protein expression was closely related to the advanced clinical stage(P=0.006),the presence of metastasis(P=0.04),perineural invasion(P=0.03)and diabetes(P=0.002),but with no influence on survival.No correlation between clinicopathological factors and ACV expression was noted.Cachexia,present in 19%of patients,was unrelated to ACV or MK level.Higher ACV expression was associated with a shorter survival(P=0.008).CONCLUSION The MK was a biomarker of perineural invasion,associated with tumor stage and diabetes,but without prognostic value as ACV.Cachexia was unrelated to perineural invasion,ACV level or survival. | Livia Petrusel Ioana Rusu Daniel Corneliu Leucuta Radu Seicean Ramona Suharoschi Paula Zamfir Andrada Seicean | 2019 | World Journal of Gastrointestinal Oncology2019，11，12： | 1 |
| 5 | Existence and data dependence of fixed points for multivalued operators on gauge spaces 显示文摘 | Espinola R Adrian Petrusel | 2005 | J Math Appl2005，309，： | 1 |
| 6 | Multivalued fractals in b-metric spaces显示文摘 | Boriceanu M Bota M Petrusel A | 2010 | Central European Journal of Mathematics2010，8，2： | 1 |
| 7 | Fixed Point Theorems for Generalized Contractions in Ordered Metric Spaces显示文摘 | O'Regan D Petrusel A | | 0，，02： | 1 |
| 8 | Fixed point results for multivalued contractions on ordered gauge spaces显示文摘 | Petrusel G | 2009 | Central European Journal of Mathematics2009，7，3： | 1 |
| 9 | Strict fixed point results for multivalued contractions on gauge spaces显示文摘 | Petrusel G Luca I | 2010 | Fixed Point Theory2010，11，1： | 1 |
| 10 | Strong convergence theorems of averaging iterations of nonexpansive nonself- mappings in Banach spaces 显示文摘 | Ceng L C Petrusel A Yao J C | 2007 | Fixed Point Theory2007，，8： | 1 |
| 11 | Fixed-point results for generalized contractions on ordered gauge spaces with applications显示文摘 | Chifu C Petrusel G | 2011 | Fixed Point Theory Applications2011，，10： | 1 |
| 12 | Multivalued fractals in b-metric spaces显示文摘 | BORICEANU M BOTA M PETRUSEL A | 2010 | Central European Journal of Mathematics2010，8，2： | 1 |
| 13 | Fixed points for non-self operators in gauge spaces显示文摘 | Lazar T Petrusel G | 2013 | Journal Nonlinear Science Applications2013，，6： | 1 |
| 14 | Fixed point Theorems for Generalized Contractions in Ordered Metric Spaces 显示文摘 | Donal O' Regan Adrian Petrusel | 2008 | J Math Anal Appl2008，341，2： | 1 |
| 15 | Fixed point theorems for generalized contractions in ordered metric Spaces显示文摘 | REGAN D PETRUSEL A | 2008 | J Math Anal Appl2008，341，： | 1 |
| 16 | Fixed point theorems for generalized contractions in ordered metric spaces显示文摘 | Ol~egan D Petrusel A | 2008 | Math Anal Appl2008，341，12： | 1 |
| 17 | Viscosity Approximations by Generalized Contractions for Resolvents of Accretive Operators in Banach Spaces显示文摘在这篇论文,我们由粘性近似方法在一个 Banach 空格为 accretive 操作符的溶剂证明一条强壮的集中定理,概括收缩印射。在一个 Banach 空格的近似的点算法也被考虑。结果扩大 W 的一些很最近的定理。Takahashi。 | Adrian PETRUSEL Jen-Chih YAO | 2009 | Acta Mathematica Sinica,English Series2009，25，4： | 0 |
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