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| 1 | PTEN in liver diseases and cancer显示文摘The phosphoinositide 3-kinase (PI3K)/phosphatase and tensin homolog (PTEN)/Akt axis is a key signal transduction node that regulates crucial cellular functions, including insulin and other growth factors signaling, lipid and glucose metabolism, as well as cell survival and apoptosis. In this pathway, PTEN acts as a phosphoinositide phosphatase, which terminates PI3Kpropagated signaling by dephosphorylating PtdIns(3,4)P2 and PtdIns(3,4,5)P3. However, the role of PTEN does not appear to be restricted only to PI3K signaling antagonism, and new functions have been recently discovered for this protein. In addition to the well-established role of PTEN as a tumor suppressor, increasing evidence now suggests that a dysregulated PTEN expression and/or activity is also linked to the development of several hepatic pathologies. Dysregulated PTEN expression/activity is observed with obesity, insulin resistance, diabetes, hepatitis B virus/hepatitis C virus infections, and abusive alcohol consumption, whereas mutations/deletions have also been associated with the occurrence of hepatocellular carcinoma. Thus, it appears that alterations of PTEN expression and activity in hepatocytes are common and recurrent molecular events associated with liver disorders of various etiologies. These recent f indings suggest that PTEN might represent a potential common therapeutic target for a number of liver pathologies. | Marion Peyrou Lucie Bourgoin Michelangelo Foti | 2010 | World Journal of Gastroenterology2010，16，37： | 16 |
| 2 | phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease显示文摘AIM: To investigate the protein expression of phosphatase and tensin homolog(PTEN) in human liver biopsies of patients with alcoholic and non-alcoholic liver disease.METHODS: PTEN protein expression was assessed by immunohistochemistry in formalin-fixed, paraffinembedded liver sections of patients with non-alcoholic fatty liver disease(NAFLD)(n = 44) or alcoholic liver disease(ALD)(n = 25). Liver resections obtained from 3 healthy subjects candidate for partial liver donation served as controls. Histological evaluations were performed by two experienced pathologists, and diagnoses established based on international criteria. The intensity of the PTEN staining in nuclei was compared between steatotic and non-steatotic areas of each liver fragment analyzed. For each liver specimen, the antibody-stained sections were examined and scored blindly by three independent observers, who were unaware of the patients' clinical history.RESULTS: In healthy individuals, PTEN immunostaining was intense in both the cytoplasm and nuclei of all hepatocytes. However, PTEN was strongly downregulated in both the nucleus and the cytoplasm of hepatocytes from steatotic areas in patients with NAFLD, independently of the disease stage. In contrast, no changes in PTEN protein expression were observed in patients with ALD, regardless of the presence of steatosis or the stage of the disease. The degree of PTEN downregulation in hepatocytes of patients with NAFLD correlated with the percentage of steatosis(r = 0.3061, P = 0.0459) and the BMI(r = 0.4268, P = 0.0043). Hovewer, in patients with ALD, PTEN expression was not correlated with the percentage of steatosis with or without obesity as a confounding factor(P = 0.5574). Finally, PTEN expression level in steatotic areas of ALD patients was significantly different from that seen in steatotic areas of NAFLD patients(P < 0.0001).CONCLUSION: PTEN protein expression is downregulated early in NAFLD, but not in ALD. PTEN immunohistochemical detection could help in the differential diagnosis of NAFLD and ALD. | Andrea Sanchez-Pareja Sophie Clément Marion Peyrou Laurent Spahr Francesco Negro Laura Rubbia-Brandt Michelangelo Foti | 2016 | World Journal of Gastroenterology2016，22，14： | 2 |
| 3 | Effect of endoplasmie retieulum stress precondi- tioning on eytotoxicity of clinically relevant nephrotoxins in renal cell lines 显示文摘 | Peyrou M Cribb AE | 2007 | Toxieol In Vitro2007，21，5： | 1 |
| 4 | Cisplatin, gentamicin, and p- aminnphennl induce markers of endoplasmic reticulum stress in the rat kidneys 显示文摘 | Peyrou M Hanna PE Cribb AE | 2007 | Toxicol Sci2007，99，： | 1 |
| 5 | Abnormal left ventrieular contraction sequence in hypertrophic car- diomyopathy patients: first description of hypersyn- ehrony and invert synehrony显示文摘 | Duchateau J Cornolle C Peyrou J | 2015 | Ultrasound Med Biol2015，41，6： | 1 |
| 6 | Direct effects of lightning on aircraft structure:analysis of the thermal,electrical and mechanical constraints显示文摘 | Chemartin L Lalande P Peyrou B | 2012 | Journal of Aerospace Lab2012，21，5： | 1 |
| 7 | Individual contribution of grain outer layers and their cell wall structure to the mechanical properties of wheat bran显示文摘 | Antoine C Peyrou S Mabille F | | 0，，07： | 1 |
| 8 | Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System(RAAS)peptides heightens the understanding of the effect of benazepril in dogs显示文摘 | Mochel JP Peyrou M Fink M | 2013 | J Vet Pharmacol Ther2013，36，2： | 1 |
| 9 | Down-regulation ofphosphatase and tensin homolog by hepatitis C virus core 3 a in hepato-cytes triggers the formation of large lipid droplets 显示文摘 | Clement S Peyrou M Sanchez-Pareja A | 2011 | Hepatology2011，54，1： | 1 |
| 10 | Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys 显示文摘 | Peyrou M Hanna PE Cribb AE | 2007 | Toxicol Sci2007，99，1： | 1 |
| 11 | Role of laparoscopy in blunt perforations of the small bowel显示文摘 | Mathonnet M Peyrou P Gainant A | 2003 | Surg Endosc2003，17，4： | 1 |
| 12 | Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys显示文摘 | Peyrou M Hanna PE Cribb AE | 2007 | Toxicol Sci2007，99，1： | 1 |
| 13 | Gaseous products created by electrical discharges in the atmosphere and condensation nuclei resulting from gaseous phase reactions 显示文摘 | Peyrous R Lapeyre R M | 1982 | Atmospheric Environment1982，16，5： | 1 |
| 14 | Cisplatin, gentamicin, and pamino- phenol induce markers of endoplasmic reticulum stress in the rat kid- neys显示文摘 | Peyrou M Hanna PE Cribb AE | 2007 | Toxicol Sci2007，99，1： | 1 |
| 15 | Direct effects of lightning on aircraft structure: analysis of the thermal, electrical and mechanical constraints显示文摘 | Chemartin L Lalande P Peyrou B | 2012 | Aerospace Lab2012，1，15： | 1 |
| 16 | Kinetic simulation of gaseous species created by an electrical discharge in dry or humid oxygen 显示文摘 | PEYROUS R PIGNOLET P HELD B | 1989 | Journal of Physics D -Applied Physics1989，22，： | 1 |
| 17 | Unsat- urated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN 显示文摘 | VINCIGUERRA M CARROZZINO F PEYROU M | 2009 | J Hep- atol2009，50，6： | 1 |
| 18 | Dorsal distal radius fractures in children: role of piaster in redisplacement of these fractures显示文摘 | Marcheix PS Peyrou P Longis B | 2011 | J Pediatr Orthop B2011，20，6： | 1 |
| 19 | The endo-plasmic reticulum in xenobiotic toxicity 显示文摘 | Cribb A E Peyrou M Muruganandan S | 2005 | Drug MetabRev2005，31，3： | 1 |
| 20 | Ozone generation in air and N2 +02mixtures in wire-to-cylinder reactor-An optimization attempt显示文摘 | Peyrous R Monge C Held B | 1999 | Czechoslovak Journal of Physics1999，49，3： | 1 |
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