|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Chronic hepatitis C:Treat or wait? Medical decision making in clinical practice显示文摘AIM:To analyzes the decision whether patients with chronic hepatitis C virus (HCV) infection are treated or not.METHODS:This prospective cohort study included 7658 untreated patients and 6341 patients receiving pegylated interferon α2 a/ribavirin,involving 434 physicians/institutions throughout Germany (377 in private practice and 57 in hospital settings).A structured questionnaire had to be answered prior to the treatment decision,which included demographic data,information about the personal life situation of the patients,anamnesis and symptomatology of hepatitis C,virological data,laboratory data and data on concomitant diseases.A second part of the study analyzes patients treated with pegylated interferon α2a.All questionnaires included reasons against treatment mentioned by the physician.RESULTS:Overall treatment uptake was 45%.By multivariate analysis,genotype 1/4/5/6,HCV-RNA ≤ 520 000 IU/mL,normal alanine aminotransferase (ALT),platelets ≤ 142 500/μL,age > 56 years,female gender,infection length > 12.5 years,concomitant diseases,human immunodeficiency virus co-infection,liver biopsy not performed,care in private practice,asymptomatic disease,and unemployment were factors associated with reduced treatment rate.Treatment and sustained viral response rates in migrants (1/3 of cohort) were higher than in German natives although 1/3 of migrants had language problems.Treatment rate and liver biopsy were higher in clinical settings when compared to private practice and were low when ALT and HCV-RNA were low.CONCLUSION:Some reasons against treatment were medically based whereas others were related to fears,socio-economical problems,and information deficits both on the side of physicians and patients. | Claus Niederau Dietrich Hüppe Elmar Zehnter Bernd Mller Renate Heyne Stefan Christensen Rainer Pfaff Arno Theilmeier Ulrich Alshuth Stefan Mauss | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 2 | Development of intrahepatic cholestasis by alpha - naphthylisothioeyanate in rats 显示文摘 | Krell H Hoke H Pfaff E | 1982 | Gastroenterology1982，82，： | 1 |
| 3 | Chan- ges in Eye-blink Duration and Frequency During Car Driving显示文摘 | PFAFF U FRUHSTORFER H PETER J H | 1976 | Pfltigers Arehiv-- European Journal of Physiology1976，，83： | 1 |
| 4 | Establishment of persistent hepatitis C virus infection and replication in vitro显示文摘 | Seipp S Mueller H M Pfaff E | 1997 | J Gen Virol1997，78，： | 1 |
| 5 | The relationship between so- cial support, shared decision -making and patients trust in doctors : a cross - sectional survey of 2,197 inpatients using the Cologne Patient Questionnaire 显示文摘 | Ommen O Thuem S Pfaff H | 2011 | Intl J Public Health2011，56，3： | 1 |
| 6 | Analysis of neutralizing epitopes on foot-and-mouth disease virus 显示文摘 | Pfaff E Thiel H J Beck E | 1988 | J Virol1988，62，6： | 1 |
| 7 | Peripheral Leukocytes Serve as a Possible Extrahelatic Site for Hepatitis C virus Replication显示文摘 | Muller H M Pfaff E Goeffer T | 1993 | J Gen Virol1993，74，4： | 1 |
| 8 | A functional study of miR-124 in the developing neural tube显示文摘 | Cao X Pfaff S L Gage F H | 2007 | Genes Dev2007，21，5： | 1 |
| 9 | Polyhistidine-tagged hepatitis B core particles as carriers of HIV-1/gp120 epitopes of different HIV-1 subtypes显示文摘 | Wizemann H Weiland F Pfaff E | 2000 | Biol Chem2000，381，3： | 1 |
| 10 | Litomosoicles sigmodontis cystatin acts as an immunomodulator during experimental filariasis显示文摘 | PFAFF A W SCHULZ-KEY H SOBOSLAY P T | 2002 | Int J Parasitol2002，32，2： | 1 |
| 11 | Polyhistidine-tagged hepatitis B core particles as carriers of HIV-1/gp120 epitopes of different HIV-1 subtypes显示文摘 | Wizemann H Weiland F Pfaff E | 2000 | Biol Chem2000，381，3： | 1 |
| 12 | A functional study of miR-124 in the developing neural tube显示文摘 | Cao X Pfaff S L Gage F H | 2007 | Genes Dev2007，21，： | 1 |
| 13 | Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes显示文摘 | Pfaff D H roult M Riedel M | 2008 | J Cell Sci2008，121，22： | 1 |
| 14 | The porcine humoral immune response against pseudorabies virus specifically targets attachment sites on glycoprotein gC显示文摘 | Ober B T Teufel B Wiesmuller K H Jung G Pfaff E Saalmüller A Rziha H J | 2000 | J Virol2000，74，4： | 1 |
| 15 | Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes显示文摘 | Pfaff D Héroult M Riedel M | 2008 | J Cell Sci2008，，： | 1 |
| 16 | Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus显示文摘 | PFAFF E MUSSGAY M BOHM H O | 1982 | EMBOJ1982，1，7： | 1 |
| 17 | Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart显示文摘 | Cai C L Liang X Shi Y Chu P H PfaffS L Chen J Evans S | | 0，，06： | 1 |
| 18 | Characterization and mapping of sequence-tagged microsatellite sites in the chickpea (Cicer arietinum L.) genome显示文摘 | P. Winter T. Pfaff S. M. Udupa B. Hüttel P. C. Sharma S. Sahi R. Arreguin-Espinoza F. Weigand F. J. Muehlbauer G. Kahl | 1999 | MGG - Molecular and General Genetics1999，，1： | 1 |
| 19 | Litomosoides sigmodontis cystatin acts as an immunomodulator during experimental filariasis 显示文摘 | Pfaff AW Schulz-Key H Soboslay PT | 2002 | Int J Parasitol2002，32，2： | 1 |
| 20 | Household Production and Environmental Kuznets Curves-examining the Desirability and Feasibility of Substitution显示文摘 | Pfaff A S P Chaudhuri S Nye H L M | 2004 | Environmental and Resource Economics2004，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员