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4篇 您的检索式:作者名="Philip Esteban"
    题名 作者 年代 出处 被引量
1On the measurement of Polarizatio 显示文摘Philip Esteban Ray D 1994Econometrics1994,62,4:1
2Atmospheric circulation patterns related to heavy snowfall days in Andorra Pyrenees显示文摘Pere Esteban Philip D J Javier 2005International Journal of Climatology2005,25,3:1
3On the measurement of polarization显示文摘Philip Esteban & Ray D 1994Econometrics1994,62,4:1
4Generation of knockout rabbits using transcription activator-like effector nucleases显示文摘Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platformscontributing to redefine the boundaries of modern biological research. They are composed of a non-specificcleavage domain and a tailor made DNA-binding module, which enables a broad range of genetic modifications byinducing efficient DNA double-strand breaks at desired loci. Among other remarkable uses, these nucleases havebeen employed to produce gene knockouts in mid-size and large animals, such as rabbits and pigs, respectively.This approach is cost effective, relatively quick, and can produce invaluable models for human disease studies,biotechnology or agricultural purposes. Here we describe a protocol for the efficient generation of knockout rabbitsusing transcription activator-like effector nucleases, and a perspective of the field.Yu Wang Nana Fan Jun Song Juan Zhong Xiaogang Guo Weihua Tian Quanjun Zhang Fenggong Cui Li Li Philip N Newsome Jon Frampton Miguel A Esteban Liangxue Lai 2014Cell Regeneration2014,3,1:0
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