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| 1 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 2 | Safety,immunogenicity,and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates显示文摘Although antivirals are important tools to control severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,effective vaccines are essential to control the current coronavirus disease 2019(COVID-19)pandemic.Plant-derived virus-like particle(VLP)vaccine candidates have previously demonstrated immunogenicity and efficacy against influenza.Here,we report the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a VLP bearing a SARS-CoV-2 spike protein(CoVLP)vaccine candidate formulated with or without Adjuvant System 03(AS03)or cytidine-phospho-guanosine(CpG)1018.Although a single dose of the unadjuvanted CoVLP vaccine candidate stimulated humoral and cell-mediated immune responses,booster immunization(at 28 days after priming)and adjuvant administration significantly improved both responses,with higher immunogenicity and protection provided by the AS03-adjuvanted CoVLP.Fifteen micrograms of CoVLP adjuvanted with AS03 induced a polyfunctional interleukin-2(IL-2)-driven response and IL-4 expression in CD4 T cells.Animals were challenged by multiple routes(i.e.,intratracheal,intranasal,and ocular)with a total viral dose of 106 plaque-forming units of SARS-CoV-2.Lower viral replication in nasal swabs and bronchoalveolar lavage fluid(BALF)as well as fewer SARS-CoV-2-infected cells and immune cell infiltrates in the lungs concomitant with reduced levels of proinflammatory cytokines and chemotactic factors in the BALF were observed in animals immunized with the CoVLP adjuvanted with AS03.No clinical,pathologic,or virologic evidence of vaccineassociated enhanced disease was observed in vaccinated animals.The CoVLP adjuvanted with AS03 was therefore selected for vaccine development and clinical trials. | Stéphane Pillet Prabhu SArunachalam Guadalupe Andreani Nadia Golden Jane Fontenot Pyone Pyone Aye Katharina Röltgen Gabrielle Lehmicke Philipe Gobeil Charlotte Dubé Sonia Trépanier Nathalie Charland Marc-AndréD’Aoust Kasi Russell-Lodrigue Christopher Monjure Robert V.Blair Scott D.Boyd Rudolf P.Bohm Jay Rappaport François Villinger Nathalie Landry Bali Pulendran Brian J.Ward | 2022 | Cellular & Molecular Immunology2022，19，2： | 2 |
| 3 | Maximum and minimum temperature trends for the Globe显示文摘 | Easterling David R Horton Briony Jones Philip D | 1997 | Science1997，277，： | 1 |
| 4 | Maximum andminimum temperature trends for the globe显示文摘 | David R E Briony H Philip D J | 1997 | Science1997，277，5324： | 1 |
| 5 | q-Profile Measurement in Tokomaks Using Fueling Pellets显示文摘 | Durst R D Philips P E Rowan W L | | 0，，： | 1 |
| 6 | Moisture movement in porous materials under temperature gradients显示文摘 | PHILIP J R DE VRIES D A | 1957 | Transactions American Geophysical Union1957，38，2： | 1 |
| 7 | Moisture movement in porous material under temperature gradient显示文摘 | Philip J R De Veries D A | 1957 | Trans Am Geophys Union1957，38，2： | 1 |
| 8 | Asymbiotic seed germination, in vitro seedling development, and greenhouse acclimatizalion of the threatened terrestrial orchid Bletia purpurea 显示文摘 | Daniela D Timothy R J Philip J K | 2008 | Plant Cell Tiss and Organ Cult2008，94，： | 1 |
| 9 | Image scrambling withoutbandwidth expansion显示文摘 | Ville D V D Philips W Walle R V | 2004 | IEEE Trans Circuits Syst Video Technol2004，14，6： | 1 |
| 10 | Moisture movement in porous materials under temperature gradients显示文摘 | Philip J R De Vries D A | 1957 | Trans Am Geophys Union1957，38，： | 1 |
| 11 | Drying and rewetting effects on soil microbial community composition and nutrient leaching显示文摘 | Gordon H Philip M H Bardgett R D | 2008 | Soil Biology & Biochemistry2008，40，： | 1 |
| 12 | Voriconazole - Associated Phototoxicity 显示文摘 | Ryan R Riahi B S Philip R Cohen M D | 2011 | Dermatology Online Journal2011，17，2： | 1 |
| 13 | A statistical-topographic model for mapping climatological precipitation over mountainous terrain 显示文摘 | Daly C Neilson R P Philips D L | 1994 | Journal of Applied Meteorology1994，33，： | 1 |
| 14 | Exploratory analysis of the safety climate and safety behavior relationship显示文摘 | Cooper M D Philips R | 2004 | Journal of Safety Research2004，35，5： | 1 |
| 15 | Accurate analytical method for the extraction of solar cell model parameters显示文摘 | Phang J C J Chan D S H Philips J R | 1984 | Electronics Letters1984，20，10： | 1 |
| 16 | Moisture movement in porous materials under temperature gradi- ents显示文摘 | Philip J R De Vries D A | 1957 | Transaction American Geophysical Union1957，38，2： | 1 |
| 17 | Physical properties of directly expanded extrudates formulated from partially defatted peanut flour and different types of starch显示文摘 | Suknard K Philips R D Chinnan M S | 1997 | Food Res Int1997，，： | 1 |
| 18 | Moisture movement in porous materials under temperature gradients显示文摘 | PHILIP J R DEVRIES D A | 1957 | Trans Am Geophys Union1957，38，2： | 1 |
| 19 | A New Perspective on Global Warming A symmetric trends of daily maximum and minimum temperature显示文摘 | Thomas R K Philip D J Richard W K | 1993 | Bulletin of American Meteorological Society1993，74，6： | 1 |
| 20 | Discussion “Stabilization of networked control systems with data packet dropout and transmission delays: continuous-time case” 显示文摘 | PHILIPS S M TILBURY D M MOYNE J R | 2005 | European Journal of Control2005，11，1： | 1 |
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