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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | Resurreccion,Consumer- Based Optimization of a Third-Generation Product Made from Peanut and Rice Flour 显示文摘 | I D Choi R D Phillips A V A | 2007 | Journal of Food Science2007，72，7： | 1 |
| 3 | The molecular hiology of the flavin-containing nlonooxygenases of man显示文摘 | Phillips I R Dolphin C T Clair P | 1995 | Chem Biol Interact1995，96，1： | 1 |
| 4 | Influence of the attachment of acidophilic bacteria during the oxidation of mineral sulfides显示文摘 | Phillips C V Blake Ⅱ R C | 2000 | Minerals Engineering2000，13，4： | 1 |
| 5 | Cellular Structure of Peanut-based Extruded Snack Products Using Scanning Electron Microscopy显示文摘 | I D Choi R D Phillips H S Jeong | 2004 | Jonrnal of Texture Studies2004，35，： | 1 |
| 6 | The platelet membrane glycoprotein Ⅱb-Ⅲa complex显示文摘 | Phillips D R Charo I F Parise L V | 1988 | Blood1988，714，： | 1 |
| 7 | 80 Gbit/s all optical regenerative wavelength conversion using semiconductor optical amplifier based interferometer 显示文摘 | Kelly A E Phillips I D Manning R J | 1999 | Electronics Letters1999，35，17： | 1 |
| 8 | Plasma antioxidant vitamins and carotenoids and age-related cataract显示文摘 | Gale C R Hall N F Phillips D I | 2001 | Ophthalmology2001，108，11： | 1 |
| 9 | Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA显示文摘 | Leslie A Kavanagh D Honeyborne I Pfafferott K Edwards C Pillay T Hilton L Thobakgale C Ramduth D Draenert R Le Gall S Luzzi G Edwards A Brander C Sewell A K Moore S Mullins J Moore C Mallal S Bhardwaj N Yusim K Phillips R Klenerman P Korber B Kiepiela P Walker B Goulder P | 2005 | J Exp Med2005，201，6： | 1 |
| 10 | Antisense oligonucleotides: new tools for physiology显示文摘 | Gyurko R | 1997 | News Physiol Sci1997，12，： | 1 |
| 11 | Influence of organic waste and residue mud additions on chemical, physical and microbial properties of bauxite residue sand显示文摘 | JONES B E H HAYNES R J PHILLIPS I R | 2011 | Environmental Science and Pollution Research2011，18，2： | 1 |
| 12 | Impacts of greenwaste biochar on ammonia volatilisation from bauxite processing residue sand显示文摘 | Chen C R Phillips I R Condron L M | 2013 | Plant and Soil2013，367，12： | 1 |
| 13 | Interleukin-7 respon- siveness of B220^+ B cell precursors from bone marrow decreases in aging mice显示文摘 | Jonsson J I Phillips R A | 2004 | Cell Imrntmol2004，147，： | 1 |
| 14 | Sorption and desorption behavior of tributyltin with natural sediments 显示文摘 | Burton E D Phillips I R Hawker D W | 2004 | Environ Sci Technol2004，38，24： | 1 |
| 15 | Impacts of greenwaste biochar on ammonia volatilization from bauxite processing residue sand显示文摘 | Chen C R Phillips I R Condron L M | 2013 | P/ant and Soil2013，367，12： | 1 |
| 16 | Sorption and desorption behavior of tributyltin with natural sediments显示文摘 | BURTON E D PHILLIPS I R HAWKER D W | | 0，，24： | 1 |
| 17 | Copper,lead,cadmium,and zinc sorption by waterlogged and air-dry soil显示文摘 | Phillips I R | 1999 | J Soil contamination1999，9，3： | 1 |
| 18 | Use of soil amendments to reduce nitrogen,phosphorus and heavy metal availability显示文摘 | Phillips I R | 1998 | Journal of Soil Contamination1998，7，2： | 1 |
| 19 | Cell-, tis- sue-, sex- and developmental stage-specific expression of mouseflavin-containing monooxygenases(FMOs) 显示文摘 | Janmohamed A Hernandez D Phillips I R | 2004 | Biochem Pharma- col2004，68，1： | 1 |
| 20 | Cosmogenic chlorine-36 production rates in terrestrial rocks 显示文摘 | Zreda M G Phillips F M Elmore D Kubik P W Sharma P Dorn R I | 1991 | Earth and Planetary Science Letters1991，105，： | 1 |
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