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3篇 您的检索式：作者名="Picard Nguyen"

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		题名	作者	年代	出处	被引量
	1	The absence of intrarenal ACE protects against hypertension显示文摘	Gonzalez-Villalobos Romer A Janjoulia Tea Fletcher Nicholas K Giani Jorge F Nguyen Mien TX Riquier-Brison Anne D Seth Dale M Fuchs Sebastien Eladari Dominique Picard Nicolas Bachmann Sebastian Delpire Eric Peti-Peterdi Janos Navar L Gabriel	2013	Journal of Clinical Investigation2013，，5：	1
	2	Release of potassium accompanying the dissolution of rice straw phytolith 显示文摘	Nguyen M N Dultz S Picardal F	2015	Chemosphere2015，119，：	1
	3	Characterization of functional transposable element enhancers in acute myeloid leukemia显示文摘Transposable elements(TEs)have been shown to have important gene regulatory functions and their alteration could lead to disease phenotypes.Acute myeloid leukemia(AML)develops as a consequence of a series of genetic changes in hematopoietic precursor cells,including mutations in epigenetic factors.Here,we set out to study the gene regulatory role of TEs in AML.We first explored the epigenetic landscape of TEs in AML patients using ATAC-seq data.We show that a large number of TEs in general,and more specifically mammalian-wide interspersed repeats(MIRs),are more enriched in AML cells than in normal blood cells.We obtained a similar finding when analyzing histone modification data in AML patients.Gene Ontology enrichment analysis showed that genes near MIRs in open chromatin regions are involved in leukemogenesis.To functionally validate their regulatory role,we selected 19 MIR regions in AML cells,and tested them for enhancer activity in an AML cell line(Kasumi-1)and a chronic myeloid leukemia(CML)cell line(K562);the results revealed several MIRs to be functional enhancers.Taken together,our results suggest that TEs are potentially involved in myeloid leukemogenesis and highlight these sequences as potential candidates harboring AML-associated variation.	Yingying Zeng Yaqiang Cao Rivka Sukenik Halevy Picard Nguyen Denghui Liu Xiaoli Zhang Nadav Ahituv Jing-Dong JHan	2020	Science China(Life Sciences)2020，63，5：	0

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