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| 1 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 2 | Comparison of the structure and porous texture of alumina gels synthesized by different methods 显示文摘 | PIERRE A C ELALOUI E PAJONK G M | 1998 | Langmuir1998，14，1： | 1 |
| 3 | Characterization of acetal ring conformations in poly(vinyl acetal)resins using two-dimensional nuclear magnetic resonance spectroscopy显示文摘 | Berger Pierre A Remsen Edward E Leo Gregory C | 1991 | Macromolecules1991，24，9： | 1 |
| 4 | Antithrombotic and thrombolytic therapy for ischemic stroke 显示文摘 | Gregory W A Pierre A J D E | 2008 | Chest2008，188，6： | 1 |
| 5 | NMR and IR spectroscopy of silica aerogels with different hydrophobic characteristics 显示文摘 | RASSY H E PIERRE A C | 2005 | Non-Cryst Solids2005，351，16： | 1 |
| 6 | NMR and IR spectroscopy of silica aerogels with different hydrophobic characteristics显示文摘 | RASSY H E PIERRE A C | 2005 | J Non-Cryst Solids2005，351，： | 1 |
| 7 | Fretting Fatigue Crack Growth Simulation based on a Combined Ex- perimental and XFEM Strategy 显示文摘 | BAIETTO M C PIERRES E GRAVOUIL A | 2013 | International Journal of Fatigue2013，47，1： | 1 |
| 8 | Multi-Harmonic analysis of dry friction damped system using an incremental harmonic balance method显示文摘 | Pierre C Ferri A A Dowell E H | 1985 | Journal of Applied Mechanics1985，52，： | 1 |
| 9 | A Multi-model X-FEM Strategy Dedicated to Frictional Crack Growth under Cyclic Fretting Fatigue Loadings 显示文摘 | BAIETTO M C PIERRES E GRAVOUIL A | 2010 | International Journal of Solids & Structures2010，47，10： | 1 |
| 10 | Use of the WECC WAMS in wide-area probing tests for validation of system performance and modeling 显示文摘 | HAUER J F MITTELSTADT W A MARTIN K E BUMS J W LEE H PIERRE J W TRUDNOWSKI D J | 2009 | IEEE Transactions on Power Systems2009，24，1： | 1 |
| 11 | 显示文摘 | Pierre E Frederic A Laurence D | 2005 | Talanta2005，67，： | 1 |
| 12 | Oxidation of hafnium carbide and hafnium carbide with additions of tantalum and praseodymium显示文摘 | Courtright E L Prater J T Holcomb G R Pierre G R Rapp R A | 1991 | Oxidation of Metals1991，36，56： | 1 |
| 13 | A Tabu search algorithm for cluster building in wireless sensor networks显示文摘 | Rhazi E A Pierre S | 2009 | IEEE Transaction on Mobile Computing2009，8，4： | 1 |
| 14 | Comparison of the structure and porous texture of alumina gels synthesized by different methods显示文摘 | PIERRE A C ELALOUI E PAJONK G M | 1998 | Langmuir1998，14，1： | 1 |
| 15 | Influence of the sol-gel processing method on the structure and the porous texture of nondoped aluminas显示文摘 | ELALOUI E PIERRE A C PAJONK G M | 1997 | J Catal1997，166，2： | 1 |
| 16 | Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee显示文摘 | David W Dempster Juliet E Compston Marc K Drezner Francis H Glorieux John A Kanis Hartmut Malluche Pierre J Meunier Susan M Ott Robert R Recker A Michael Parfitt | 2012 | J Bone Miner Res2012，，1： | 1 |
| 17 | Arginine and mixed ami-no acids increase protein accretion in the growth-restricted and normal ovine fetus by different mechanisms显示文摘 | Hendrina A Pierre L Desiree E C | 2005 | International Pediatric Research Foundation2005，58，： | 1 |
| 18 | How cells feel their environment: a focus on early dynamic events 显示文摘 | CRETEL E PIERRES A BENOLIEL A M | 2008 | Cell Mol Bioeng2008，1，1： | 1 |
| 19 | Tumor necrosis factor/cachectin plays a key role in bleomyein-induced pneumopathy and fi-brosis显示文摘 | PIERRE F MARTINE A GEORGS E | 1989 | J Exp Med1989，170，9： | 1 |
| 20 | Carbonization of coals in the presence of alkaline hydroxides and carbonates: formation of activated carbons 显示文摘 | PIERRE E ABDELHAMID A FATIMA A | 1986 | Fuel1986，65，10： | 1 |
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