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| 1 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 4 | Apfel's simplified score may favourably predict the risk of postoperative nausea and vomiting 显示文摘 | Pierre S Benais H Pouymayou J | 2002 | Can J Anesth2002，4，9： | 1 |
| 5 | Abnormality de- tection using low-level co-occurringevents 显示文摘 | Yannick B Pierre M J Venkatesh S | 2011 | Pattern Recognition Letters2011，32，3： | 1 |
| 6 | Muscle fiber area distribution of musculus uvulae in obstructive sleep apnea and non-apneic snorers显示文摘 | SEARIEAS F SIMONEAU J ST PIERRE S | 2000 | Int J Obesity2000，24，： | 1 |
| 7 | Critical flux determination by the flux-step method in a submerged membrane bioreactor 显示文摘 | Pierre L C Bruce J Chang I S | 2003 | Journal of Membrane Science2003，227，： | 1 |
| 8 | Remifentanil induces consistent and sustained controlled hypotension in children during middle ear surgery显示文摘 | Christian S Marie J Pierre Y | 2003 | Can J Anesth2003，50，3： | 1 |
| 9 | RnKSN, a floral repressor, forms protein complexes with RoFD and RoFT to regulate vegetative and reproductive development in rose 显示文摘 | RANDOUX M DAVIERE J M JEAUFFRE J THOUROUDE T PIERRE S TOUALBIA Y PERROTTE J REYNO1RD J P JAMMES M J HIBRAND-SAINT OYANT L FOUCHER F | 2014 | New Phytologist2014，202，1： | 1 |
| 10 | Apfel's simplified score may favourably predict the risk of postoperative nausea and vomiting显示文摘 | Pierre S Benais H Pouymayou J | 2002 | Can J Anesth2002，49，3： | 1 |
| 11 | Electrowinning of zinc from alkaline solutions at high current densities显示文摘 | Pierre J S T Piron D L | 1990 | Journal of Applied Electrochemistry1990，20，1： | 1 |
| 12 | Apfe 1 s simplified score- may favourably predict the risk of postoperative nausea and vomiting 显示文摘 | Pierre S Benais H Pouym ayou J | 2002 | Can J Anaesth2002，49，3： | 1 |
| 13 | Sulfur Equilibria Between Gases and Slags Containing FeO 显示文摘 | Pierre G R S Chipman J | 1956 | J Met1956，，10： | 1 |
| 14 | Magnetite nanoparticle dispersions stabilized with triblock copolymers显示文摘 | Harris L A Goff J D Carmichael A Y Riffle J S Harburn J J Pierre T G S Saunders M | 2003 | Chemistry of Materials2003，15，： | 1 |
| 15 | Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity显示文摘 | PIERRE M ONGE S JONES P J H | 2002 | The American Society for Nutritional Sciences: Journal of Nutrition2002，132，： | 1 |
| 16 | Cracking chaos-based encryption systems ruled by nonlinear time delay differential equations显示文摘 | Vladimir S Pierre J Laurent L | 2003 | Physics Letters A2003，308，1： | 1 |
| 17 | Traveling--wave Excitation and Optical Measurement Techniques for Non--contacting Investigation of Bladed Disk Dynamies显示文摘 | Judge J A Ceccio S L Pierre C | 2003 | The Shock and Vibration Digest2003，35，3： | 1 |
| 18 | New butenolides in plantlets of Virola surinamensis (Myristicaceae) 显示文摘 | NORBERTO P L PIERRE A D S MASSUO J K | 2004 | Chem Pharm Bull2004，52，10： | 1 |
| 19 | Bioenergetic analysis of peroxisome proliferator activated receptor gamma coactivatom 1 alpha and 1 beta ( PGC 1 alpha and PGC 1 beta) in muscle cells 显示文摘 | Pierre JST Lin J Krauss S | 2003 | J Biol Chem2003，278，50： | 1 |
| 20 | Mechanistic virtual modeling: coupling a plant simulation model with a three-dimensional plant architecture component显示文摘 | ERIC J RON S PIERRE M | 2009 | Environmental Modeling and Assessment2009，14，1： | 1 |
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