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| 1 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 2 | Pathophysiology of Coronary Artery Disease显示文摘 | Peter Libby Pierre Theroux | 2005 | Circulation2005，，25： | 3 |
| 3 | 2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction显示文摘 | Jeffrey L. Anderson Cynthia D. Adams Elliott M. Antman Charles R. Bridges Robert M. Califf Donald E. Casey William E. Chavey Francis M. Fesmire Judith S. Hochman Thomas N. Levin A. Michael Lincoff Eric D. Peterson Pierre Theroux Nanette K. Wenger R. Scott | 2013 | Journal of the American College of Cardiology2013，，23： | 2 |
| 4 | 接受纤溶治疗的ST段抬高心肌梗死患者在经皮冠状动脉介入治疗前服用氯吡格雷的效果:PCI-CLARITY研究显示文摘背景:关于经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)前氯吡格雷预治疗的益处目前仍有争议,并且其使用亦未获得普遍认可。
目的:于新近发生ST段抬高心肌梗死(ST—segment elevation myocardial infarction,STEMI)的患者中确定PCI前氯吡格雷预治疗预防严重不良心血管事件的效果是否优于PCI时开始采用氯吡格雷治疗。
设计、地点及参试者:CLARITY(PCI—Clopidogrel as Adjunctive Reperfusion Therapy)研究是一项于1863例患者中进行的前瞻性计划分析。这些患者均于CLARITY—TIMI(Thrombolysis in Myocardial Infarction)28试验中在血管造影后实施了PCI。CLARITY—TIMI28是一项在接受纤溶治疗的患者中进行的有关氯吡格雷效果的随机、双盲、安慰剂对照试验。患者于2003年2月至2004年10月入选自23个国家的319家医院。
干预:患者服用阿斯匹林并于纤溶治疗时开始随机接受氯吡格雷(300mg负荷剂量,以后75mg,每日1次)或安慰剂,直至冠状动脉造影前为止。造影在开始研究药物后2~8天进行。接受冠脉支架的患者建议于诊断性血管造影后给予开标氯吡格雷(包括负荷剂量)。
主要观测指标:一级终点为PCI至随机分组后30天心血管死亡、MI复发或脑卒中的复合发生率。二级终点包括在PCI之前发生的MI或脑卒中以及前述随机分组后30天相关终点。
结果:氯吡格雷预治疗可显著降低PCI后心血管死亡、MI或脑卒中的发生率(34[3.6%]比58[6.2%];校正优势比[odds ratio,OR],0.54[95%CI,0.35—0.85];P=0.008)。氯吡格雷预治疗还可降低PCI前MI或脑卒中的发生率(37[4.0%]比58[6.2%];OR,0.62[95%CI,0.40~0.95];P=0.03)。总体上,氯吡格雷预治疗可导致随机分组后30天心血管死亡、MI或脑卒中显著下降(70[7.5%]比112[12.0%];校正OR,0.59[95%CI,0.43~0.81];P=0.001;所需治疗例数=23)。TIMI严重或轻微出血的发生率未显著增加((18[20%]比17[1.9%];P〉0.99)。
结论:氯吡格雷预治疗可显著降低PCI前后心血管死亡或缺血并发症,而严重或轻微出血无显著增加。这些数据为STEMI患者早期使用氯吡格雷以及接受PCI的患者常规采用氯吡格雷预治疗方案提供了进一步的支持。 | Marc S. Sabatine Christopher P.Cannon C. Michael Gibson Jose L Lopez-Sendon Gilles Montalescot Pierre Theroux Basil S. Lewis Sabina A. Murphy Carolyn H. McCabe Eugene Braunwald 李呈亿(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 2 |
| 5 | Signaling crossroads:the function of Raf kinase inhibitory protein in cancer,the central nervous system and reproduction显示文摘 | Klysik J Theroux SJ Sedivy JM | 2008 | Cell Signal2008，20，4： | 1 |
| 6 | Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina显示文摘 | Theroux P Waters D Qiu S | 1993 | Circulation1993，88，51： | 1 |
| 7 | Effect of platelet glycoproteirl Ⅱb/Ⅲa receptor blockade with tirofiban on adverse cardiac events in women with unstable angina/non-ST elevation myocardial in- farction ( PRISM-PLUS study )显示文摘 | Huynh T Theroux P Snapinn S | 2003 | Am Heatrt J2003，146，4： | 1 |
| 8 | 2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update)显示文摘 | Hani Jneid Jeffrey L. Anderson R. Scott Wright Cynthia D. Adams Charles R. Bridges Donald E. Casey Steven M. Ettinger Francis M. Fesmire Theodore G. Ganiats A. Michael Lincoff Eric D. Peterson George J. Philippides Pierre Theroux Nanette K. Wenger James P | 2012 | Journal of the American College of Cardiology2012，，7： | 1 |
| 9 | Pathophysiology of coronary artery disease 显示文摘 | Libby P Theroux P | 2005 | Circulation2005，111，25： | 1 |
| 10 | Acute coronarv syndromes:unstable angina and non-Q-wave myocardial infarction显示文摘 | Theroux P Fuster V | 1998 | Circulation1998，97，： | 1 |
| 11 | Clincal and anglographic features of non- Q wave and Q wave myocardial infarction显示文摘 | Theroux P Koug S Bosch X | 1986 | Circulation1986，74，： | 1 |
| 12 | Unstable angina: pathogenesis, diagnosis, and treatment显示文摘 | Theroux P Lidon R M | 1993 | Curr Probl Cardiol1993，18，3： | 1 |
| 13 | 2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction显示文摘 | R. Scott Wright Jeffrey L. Anderson Cynthia D. Adams Charles R. Bridges Donald E. Casey Steven M. Ettinger Francis M. Fesmire Theodore G. Ganiats Hani Jneid A. Michael Lincoff Eric D. Peterson George J. Philippides Pierre Theroux Nanette K. Wenger James P | 2011 | Journal of the American College of Cardiology2011，，19： | 1 |
| 14 | Unstable angina: Pathogenesis, diag-nosis, and treatment显示文摘 | Theroux P lidon RM | 1993 | Curt Probl Caldiol1993，18，3： | 1 |
| 15 | Cone and seed morphology of western larch {Larix occidentiaLs) alpine larch {Larix lyallii) and theirhybrids显示文摘 | CARLSON C E THEROUX L J | 1993 | Canadian Journal of Forest Research1993，23，： | 1 |
| 16 | Pathophysiology of coronary artery disease 显示文摘 | Libby P Theroux P | 2005 | Circulation2005，111，： | 1 |
| 17 | Aspirin versus heparin to prevent myocardial infarction during the acute phase of unstable angina显示文摘 | Wacers P Qiu S | 1993 | Circulation1993，88，： | 1 |
| 18 | Aspirin,heparin,or both to treat acute unstable angina显示文摘 | Theroux P Ouimet H McCans J | 1998 | N Engl J Med1998，319，37： | 1 |
| 19 | Pathophysiology of coronary artery disease 显示文摘 | Libby P Theroux P | 2005 | Circulation2005，，： | 1 |
| 20 | Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction: insights from the APEX-AMI trial显示文摘 | Sean Diepen Matthew Roe Renato Lopes Amanda Stebbins Stefan James L. Newby David Moliterno Franz-Josef Neumann Justin Ezekowitz Kenneth Mahaffey Judith Hochman Christian Hamm Paul Armstrong Pierre Theroux Christopher Granger | 2012 | Journal of Thrombosis and Thrombolysis2012，，1： | 1 |
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