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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | Critical flux determination by the flux-step method in a submerged membrane bioreactor 显示文摘 | Pierre L C Bruce J Chang I S | 2003 | Journal of Membrane Science2003，227，： | 1 |
| 3 | Real investment decision under adjustment costs and asymmetric information显示文摘 | Gauder G Pierre L Long I V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 4 | Real investment decisions under adjustment costs and asymmetric information显示文摘 | Gauder G Pierre L Long I V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 5 | Real investment decisions under adjustment costs and asymmetric information 显示文摘 | GAUDER G PIERRE L LONG I V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 6 | Macro - economic Consequences of European Research Policy:Prospects of the Nemesis Model in the Year 2030显示文摘 | Doroth 6 e Br card Amand Fougeyrollas Pierre Le Mou?l Lionel I emiale Paul Zagam | 2006 | Research Policy2006，，7： | 1 |
| 7 | Fetal sex and indicated very preterm birth: Result of the EPIPAGE study显示文摘 | Jennifer I Pierre -Yves A Beatrice L | 2004 | Am J Obstet Gynecol2004，190，： | 1 |
| 8 | Real investment decision under adjustment costs and asymmetric information显示文摘 | Gauder G Pierre L Long I V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 9 | A linear thermoviscoelastic material modelfor solid rocket motor structural analysis 显示文摘 | Jones I W Pierre E L | 1985 | Computers andStructures1985，21，1： | 1 |
| 10 | Pulmonary involvement in Erdheim-Chester disease: a single-center study of thirty-four patients and a review of the literature 显示文摘 | Arnaud L Pierre I Beigelman-Aubry C | 2010 | Arthritis Rheum2010，62，11： | 1 |
| 11 | Real investment decisions under adjustment costs and asymmetric information显示文摘 | Gauder G Pierre L Long I V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 12 | Ginkgo biloba extract(EGb 761) protects Na,K-ATPase activity during cerebral ischemia in mice显示文摘 | Pierre S Jamme I Droy L | 1999 | Neuroreport1999，10，1： | 1 |
| 13 | Real investment decisions under adjustment costs and asymmetric information 显示文摘 | Gauder G Pierre L Long I V | 1998 | J of Economic Dynamics and Control1998，23，1： | 1 |
| 14 | Real investment decisions under adjustment costs and asymmetric information 显示文摘 | Gauder G Pierre L Long I V V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 15 | Real investment decision under adjustment costs and asymmetric information显示文摘 | Pierre L Long I V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 16 | Ginkgo biloba extract(EGb 761)protects Na,K-ATPase activity during cerebral ischemia in mice显示文摘 | Pierre S Jamme I Droy L | 1999 | Neuroreport1999，10，1： | 1 |
| 17 | Real investment decision under adjustment costs and asymmetric information显示文摘 | Gauder G Pierre L Long I V | 1998 | Journal of Economic Dynamics and Control1998，23，1： | 1 |
| 18 | Biodiversity and endemism mapping as a tool for regional conservation planning case study of the Pleurothallidinae (Orchidaceae) of the Andean rain forests in Bolivia显示文摘 | Robert M Christoph N Wilhelm B Pierre L I | 2003 | Biodiversity and Conservation2003，12，： | 1 |
| 19 | Interaction between age and gender on survival outcomes in extramedullary multiple myeloma over the past two decades显示文摘BACKGROUND Extramedullary multiple myeloma(MM)(EMM)is a rare and aggressive subentity of MM that can be present at diagnosis or develop anytime during the disease course.There is a paucity of data on the clinical characteristics and overall epidemiology of EMM.Furthermore,there is a scarcity of data on how the interaction of age and gender influences the survival of EMM.AIM To evaluate the clinical characteristics of patients with EMM over the past 2 decades and to identify epidemiologic characteristics that may impact overall prognosis.METHODS A total of 858 patients diagnosed with EMM,between 2000 and 2017,were ultimately enrolled in our study by retrieving the Surveillance,Epidemiology,and End Results database.We analyzed demographics,clinical characteristics,and overall mortality(OM)as well as cancer-specific mortality(CSM)of EMM.Variables with a P value<0.1 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors,with a hazard ratio(HR)of greater than 1 representing adverse prognostic factors.RESULTS From a sample of 858 EMM,the male gender(63.25%),age range 60-79 years(51.05%),and non-Hispanic whites(66.78%)were the most represented.Central Nervous System and the vertebral column was the most affected site(33.10%).Crude analysis revealed higher OM in the age group 80+[HR=6.951,95%confidence interval(95%CI):3.299-14.647,P=0],Non-Hispanic Black population(HR=1.339,95%CI:1.02-1.759,P=0.036),Bones not otherwise specified(NOS)(HR=1.74,95%CI:1.043-2.902,P=0.034),and widowed individuals(HR=2.107,95%CI:1.511-2.938,P=0).Skin involvement(HR=0.241,95%CI:0.06-0.974,P=0.046)and a yearly income of$75000+(HR=0.259,95%CI:0.125-0.538,P=0)had the lowest OM in the crude analysis.Crude analysis revealed higher CSM in the age group 80+,Non-Hispanic Black,Bones NOS,and widowed.Multivariate cox proportional hazard regression analyses only revealed higher OM in the age group 80+(HR=9.792,95%CI:4.403-21.774,P=0)and widowed individuals(HR=1.609,95%CI:1.101-2.35,P=0.014).Multivariate cox proportional hazard regression analyses of CSM also revealed higher mortality of the same groups.Eyes,mouth,and ENT involvement had the lowest CSM in the multivariate analysis.There was no interaction between age and gender in the adjusted analysis for OM and CSM.CONCLUSION EMM is a rare entity.To our knowledge,there is a scarcity of data on the clinical characteristics and prognosis factors of patients with extramedullary multiple myeloma.In this retrospective cohort,using a United States-based population,we found that age,marital status,and tumor site were independent prognostic factors.Furthermore,we found that age and gender did not interact to influence the mortality of patients with EMM. | Ayrton I Bangolo Pierre Fwelo Chinmay Trivedi Sowmya Sagireddy Hamed Aljanaahi Auda Auda Maryama Mohamed Sonia Onyeka Miriam Fisher Jyoti Thapa Erwin J Tabucanon Lyuben Georgiev Annetta Wishart Shilpee Kumari Conrad Erikson Mary Bangura Orent Paddy Rashmi Madhukar Eugenio L Gomez Joshua Rathod Mansi Naria Basel Hajal Mohammad Awadhalla David Siegel Harsh Parmar Noa Biran David H Vesole Pooja Phull Simcha Weissman | 2023 | World Journal of Clinical Oncology2023，14，4： | 1 |
| 20 | Real investment decis on under adjustment costs and asymmetric information 显示文摘 | Gauder G Pierre L Long I V | 1998 | Journal of Economic Dynamics and Control1998，，： | 1 |
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