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| 1 | Helicobacter pylori infection in older people显示文摘Since the discovery of Helicobacter pylori(H.pylori)infection as the major cause of gastroduodenal disorders three decades ago,H.pylori has been the focus of active research and debate in the scientific community.Its linkage to several diseases,such as peptic ulcer disease,gastritis and gastric malignancy is incontestable.In particular,it has been noticed that,as the aged population is increasing worldwide,older people are at increased risk of developing several gastroduodenal diseases and related complications.At the same time,gastric cancer is definitely more frequent in elderly than in adult and young people.In addition,it has been showed that peptic ulcer and related complications occur much more commonly in aged individuals than in young people,resulting in a significantly higher mortality.Although this infection plays a crucial role in gastrointestinal disorders affecting all age groups and in particular older people,only a few studies have been published regarding the latter.This article presents an overview of the epidemiology,diagnosis,clinical manifestations and therapy of H.pylori infection in elderly people. | Alberto Pilotto Marilisa Franceschi | 2014 | World Journal of Gastroenterology2014，20，21： | 6 |
| 2 | Focus on acute diarrhoeal disease显示文摘Diarrhoea is an alteration of normal bowel movement characterized by an increase in the water content, volume, or frequency of stools. Diarrhoea needs to be classif ied according to the trends over time (acute or chronic) and to the characteristics of the stools (watery, fatty, inflammatory). Secretory diarrhoeas, mostly acute and of viral aetiology in more than 70% of cases, are by far the most important subtype of diarrhoeas in terms of frequency, incidence and mortality (over 2.5 million deaths/year in developing countries). Natural and synthetic opiates such as morphine, codeine, and loperamide which react with endogenous opiates (enkephalins, beta-endorphins, dynorphins) mainly act on intestinal motility and slow down transit. An antidiarrhoeal drug developed in recent years, racecadotril, acts as an enkephalinase inhibitor. Clinical studies have shown that it is just as effective as loperamide in resolving acute diarrhoea but with greater reduction in pain and abdominal distension. Some studies have explored the prevalence of diarrhoea in old age. An epidemiological study carried out in Italy by 133 General Practitioners on 5515 elderly outpatients reported a prevalence of diarrhoea, def ined according to the Rome criteria, of 9.1%. Infectious diseases (19%) and drug use (16%) were the most common causes of diarrhoea in old age. Regardless of the cause, the treatment of elderly patients with diarrhoea must include rehydration and nutritional support. Every year, more than 50 million tourists travel from industrialized countries to places where hygiene levels are poor. At least 75% of those travelling for short periods mention health problems, and in particular traveller's diarrhoea. | Fabio Baldi Maria Antonia Bianco Gerardo Nardone Alberto Pilotto Emanuela Zamparo | 2009 | World Journal of Gastroenterology2009，15，27： | 6 |
| 3 | Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patients显示文摘AIM: To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients.METHODS: A total of 320 patients over 65 years with endoscopically diagnosed esophagitis were randomly assigned to one of the following treatments for 8 wk: (1) omeprazole 20 mg/d; (2) lansoprazole 30 mg/d; (3) pantoprazole 40 mg/d, or (4) rabeprazole 20 mg/d. Major symptoms, compliance, and adverse events were recorded. After 8 wk, endoscopy and clinical evaluation were repeated.RESULTS: Per protocol and intention to treat healing rates of esophagitis were: omeprazole = 81.0% and 75.0%, lansoprazole = 90.7% (P = 0.143 vs omeprazole) and 85.0%, pantoprazole = 93.5% (P = 0.04 vs omeprazole) and 90.0% (P = 0.02 vs omeprazole), rabeprazole = 94.6% (P = 0.02 vs omeprazole) and 88.8% (P = 0.04 vs omeprazole). Dividing patients according to the grades of esophagitis, omeprazole was significantly less effective than the three other PPIs in healing grade 1 esophagitis (healing rates: 81.8% vs 100%, 100% and 100%, respectively, P = 0.012). Pantoprazole and rabeprazole (100%) were more effective vs omeprazole (89.6%, P = 0.0001)and lansoprazole (82.4%, P = 0.0001) in decreasing heartburn. Pantoprazole and rabeprazole (92.2% and 90.1%, respectively) were also more effective vs lansoprazole (75.0%, P < 0.05) in decreasing acid regurgitation. Finally, pantoprazole and rabeprazole (95.2% and 100%) were also more effective vs lansoprazole (82.6%, P < 0.05) in decreasing epigastric pain.CONCLUSION: In elderly patients, pantoprazole and rabeprazole were significantly more effective than omeprazole in healing esophagitis and than omeprazole or lansoprazole in improving symptoms. H pylori infection did not influence the healing rates of esophagitis after a short-term treatment with PPI. | Alberto Pilotto Marilisa Franceschi Gioacchino Leandro Carlo Scarcelli Luigi Piero D'Ambrosio Francesco Paris Vito Annese Davide Seripa Angelo Andriulli Francesco Di Mario | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 4 | ABC transporters and the hallmarks of cancer:roles in cancer aggressiveness beyond multidrug resistance显示文摘The ATP-binding cassette transporters(ABC transporters)have been intensely studied over the past 50 years for their involvement in the multidrug resistance(MDR)phenotype,especially in cancer.They are frequently overexpressed in both naive and post-treatment tumors,and hinder effective chemotherapy by reducing drug accumulation in cancer cells.In the last decade however,several studies have established that ABC transporters have additional,fundamental roles in tumor biology;there is strong evidence that these proteins are involved in transporting tumor-enhancing molecules and/or in protein-protein interactions that impact cancer aggressiveness,progression,and patient prognosis.This review highlights these studies in relation to some well-described cancer hallmarks,in an effort to re-emphasize the need for further investigation into the physiological functions of ABC transporters that are critical for tum or development.Unraveling these new roles offers an opportunity to define new strategies and targets for therapy,which would include endogenous substrates or signaling pathways that regulate these proteins. | Wanjiru Muriithi Lucy Wanjiku Macharia Carlos Pilotto Heming Juliana Lima Echevarria Atunga Nyachieo Paulo Niemeyer Filho Vivaldo Moura Neto | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 5 | Optimal Management of Peptic Ulcer Disease in the Elderly显示文摘 | Alberto Pilotto Marilisa Franceschi Stefania Maggi Filomena Addante Daniele Sancarlo | 2010 | Drugs & Aging2010，，7： | 3 |
| 6 | Association of upper gastrointestinal symptoms with functional and clinical characteristics in the elderly显示文摘AIM:To evaluate the prevalence of upper gastrointestinal symptoms and their association with clinical and functional characteristics in elderly outpatients.METHODS:The study involved 3238 outpatients ≥ 60 years consecutively enrolled by 107 general practitioners.Information on social,behavioral and demographic characteristics,function in the activities of daily living (ADL),co-morbidities and drug use were collected by a structured interview.Upper gastrointestinal symptom data were collected by the 15-items upper gastro-intestinal symptom questionnaire for the elderly,a validated diagnostic tool which includes the following five symptom clusters:(1) abdominal pain syndrome;(2) reflux syndrome;(3) indigestion syndrome;(4) bleeding;and (5) non-specific symptoms.Presence and severity of gastrointestinal symptoms were analyzed through a logistic regression model.RESULTS:3100 subjects were included in the final analysis.The overall prevalence of upper gastrointestinal symptoms was 43.0%,i.e.cluster (1) 13.9%,(2) 21.9%,(3) 30.2%,(4) 1.2%,and (5) 4.5%.Upper gastrointestinal symptoms were more frequently reported by females (P < 0.0001),with high number of co-morbidities (P < 0.0001),who were taking higher number of drugs (P < 0.0001) and needed assistance in the ADL.Logistic regression analysis demonstrated that female sex (OR=1.39,95% CI:1.17-1.64),disability in the ADL (OR=1.47,95% CI:1.12-1.93),smoking habit (OR=1.29,95% CI:1.00-1.65),and body mass index (OR=1.06,95% CI:1.04-1.08),as well as the presence of upper (OR=3.01,95% CI:2.52-3.60) and lower gastroenterological diseases (OR=2.25,95%CI:1.70-2.97),psychiatric (OR=1.60,95% CI:1.28-2.01) and respiratory diseases (OR=1.25,95% CI:1.01-1.54) were significantly associated with the presence of upper gastrointestinal symptoms.CONCLUSION:Functional and clinical characteristics are associated with upper gastrointestinal symptoms.A multidimensional comprehensive evaluation may be useful when approaching upper gastrointestinal symptoms in older subjects. | Alberto Pilotto Stefania Maggi Marianna Noale Marilisa Franceschi Giancarlo Parisi Gaetano Crepaldi | 2011 | World Journal of Gastroenterology2011，17，25： | 3 |
| 7 | Mid-term outcome comparing temporary K-wire fixation versus PDS augmentation of Rockwood grade III acromioclavicular joint separations 显示文摘 | Leidel BA Braunstein V Pilotto S | 2009 | BMC Research Notes2009，2，： | 1 |
| 8 | Review article:an approach to Helicobacter pylori infection in the elderly显示文摘 | Pilotto A Malfertheiner P | 2002 | Aliment Pharmacol Ther2002，16，4： | 1 |
| 9 | Diverticular disease in the elderly显示文摘 | Comparato G Pilotto A Franzè A | 2007 | Dig Dis2007，25，2： | 1 |
| 10 | Health effects of recreational exposure to cyanobacteria(bluegreen algae) during recreational water-related activities显示文摘 | Pilotto L S Douglas R M Burch M D | 1997 | Australian and New Zealand Journal of Public Health1997，21，： | 1 |
| 11 | alphaB-mystallin mutation in dilated cardiomyopathies: low prevalence in a consecutive series of 200 unrelated probands 显示文摘 | Pilotto A Marziliano N Pasotti M | 2006 | Biochem Biophys Res Commun2006，346，： | 1 |
| 12 | Effect of helicobacter pylori eradication on the outcome of reflux esophagitis and chronic gastritis in the elderly, a randomized, multicenter, eight-month study 显示文摘 | Pilotto A Peril F Leandro G | 2006 | Gerontology2006，52，2： | 1 |
| 13 | Review article: an approach to Helico- bacter pylori infection in the elderly显示文摘 | Pilotto A Malfertheiner P | 2002 | Aliment Pharmacol Ther2002，16，4： | 1 |
| 14 | Impact of TCSC control methodologies on subsynchronous oscillations显示文摘 | Pilotto L A S Bianco A Long W F | 2003 | IEEE Trans on Power Delivery2003，18，1： | 1 |
| 15 | Optimal management of peptic ulcer disease in the elderly显示文摘 | Pilotto A Franceschi M Maggi S | 2010 | Drugs Aging2010，27，7： | 1 |
| 16 | Tissue plasminogen activator -7351C/T enhancer polymorphism is a risk factor for lacunar stroke显示文摘 | Jannes J Hamilton-Bruce MA Pilotto L | 2004 | Stroke2004，35，： | 1 |
| 17 | Adjuvant chemotherapy for resected non-small-cell lung cancer: future perspectives for clinical research 显示文摘 | Bonomi M Pilotto S Milella M | 2011 | J Exp Clin Cancer Res2011，30，1： | 1 |
| 18 | The long-term clinical outcome of elderly patients with Helicobacter pylori-associated pep- tic ulcer disease显示文摘 | Pilotto A Franceschi M Di Mario F | 1998 | Gerontol1998，44，3： | 1 |
| 19 | Diabetic macular edema:correlation between microperimetry and optical coherence tomography findings显示文摘 | Vujosevic S Midena E Pilotto E | | 0，，： | 1 |
| 20 | Respiratory effects associated with indoor nitrogen dioxide exposure in children 显示文摘 | Pilotto LS Douglas RM Attewell RG | 1997 | Intemational Journal of Epidemiology1997，26，4： | 1 |
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