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| 1 | Protective role of metallothionein in stress-induced gastric ulcer in rats显示文摘AIM: To illustrate the pathophysiological role of metallothionein (MT) in gastric ulcer induced by stress. METHODS: Wistar rats underwent water-immersionrestraint (WIR) stress, ZnSO4 (an MT inducer) treatment, WIR+ZnSO4 or WIR+MT, and the ulcer index (UI) was estimated in excised stomach and liver tissues. The mRNA level of gastric MT was determined by semi-quantitative RT-PCR. The MT content in gastric and hepatic tissues was determined by Cd/hemoglobin affinity assay. The lipid peroxidation products malondialdehyde (MDA) and conjugated dienes (CD) were estimated by use of thiobarbituric acid reactive species and ultraviolet spectrophotometry. RESULTS: WIR stress induced severe gastric mucosal lesions in rats. Compared with control rats, stressed rats had increased lipid peroxide content in serum and stomach and liver tissues. MDA content was increased by 34%, 21% and 29% and CD level by 270%, 83% and 28%, respectively. MT content in the stomach and liver was increased by 0.74- and 1.8-fold, and the MT-mRNA level in the stomach was increased by 26%. Pretreatment with ZnSO4 prevented gastric lesion development (the UI was 87% lower than that without pretreatment), and the MDA and CD content in serum and tissues was lower. The MT content in the liver was double in rats that were not pretreated, and the MT mRNA level in the stomach was 35% higher. MT administration 1 h before the WIR stress prevented gastric lesion development (the UI decreased by 47% compared with that in rats not pretreated), and the MDA and CD content in serum and tissues was significantly lower. CONCLUSION: In WIR-stressed rats, the MT level was increased in serum and in stomach and liver tissues. Pre-administration of exogenous MT or pre-induction of endogenous MT can protect the gastric mucosa against stress-induced ulcers and inhibits the formation of stressinduced lipid peroxide. MT could have a gastroprotective effect and might be a new interventive and therapeutic target in stress-induced gastric ulcers. | PingJiang LinChang Chun-ShuiPan Yong-FenQi Chao-ShuTang | 2005 | World Journal of Gastroenterology2005，11，18： | 9 |
| 2 | Enhanced immune responses of mice inoculated recombinant udenoviruses expressing GP5 by fusion with6P3 and or GP4 of PRRS virus显示文摘 | WenmingJiang PingJiang Xianweiwang | 2008 | Virus Research2008，136，： | 1 |
| 3 | Corporate Governance in China: a Step Forward显示文摘 | Yan‐LeungCheung PingJiang PimanLimpaphayom TongLu | 2009 | European Financial Management2009，，1： | 1 |
| 4 | A seam-tracking laser welding platform with 3D and 2D visual infirmation fusion vision sensor system显示文摘 | Yu Huang Yangliu Xiao Pingjiang Wang | 2013 | The International Journal of Advanced Manu- faeturing Technology2013，，： | 1 |
| 5 | Puerarin protects human umbilical vein endothelial cells against high glucose‐induced apoptosis by upregulating heme oxygenase‐1 and inhibiting calpain activation显示文摘 | Ying‐YingChen JieChen Xin‐MeiZhou Xiang‐HongMeng Jian‐PingJiang Yue‐LiangShen | 2012 | Fundamental & Clinical Pharmacology2012，，3： | 1 |
| 6 | Bioaccumulation and trophic transfer of polybrominated diphenyl ethers(PBDEs) in biota from the Pearl River Estuary, South China 显示文摘 | YU Mei LUO Xiaojun WU Pingjiang | 2009 | Environ Intern2009，35，7： | 1 |
| 7 | 努力探索贫困县农业综合开发新途径显示文摘平江县位于湖南省东北部,是一个典型的'老、山、边、穷、大'五位一体的农业大县,也是国家级贫困县。近几年来,平江县农业综合开发办公室不断总结经验教训,努力探索农业综合开发的新途径,逐步完善有关政策,使平江县农业综合开发迈上了一个新的台阶。 | Agricultural Comprehensive Development Office in Pingjiang | 2007 | 农业开发与装备2007，，9： | 0 |
| 8 | Altered subcellular distribution of nucleolar protein fibrillarin by actinomycin D in HEp-2 cells显示文摘AIM: To study the effects of actinomycin D on subcellular distribution of nucleolar protein fibrillarin in HEp-2 (human esophageal epithelial type 2) cells, and molecular mechanisms for maintenance of fibrillarin in nucleolus. METHODS: Indirect immunofluorescence assay was employed to investigate subcellular distribution of nucleolar protein fibrillarin and immunoblotting analysis was used to detect the total cellular amount of fibrillarin. RESULTS: Control cells with no drug treatment showed bright clumpy nucleolar staining, which indicated that fibrillarin decorated the nucleolus only. Treatment with actinomycin D caused dislocation of fibrillarin from nucleoli to nucleoplasm with numerous stained small nucleoplasmic entities. Immunoblotting showed that neither total cellular amount of fibrillarin nor the integrity of fibrillarin was changed upon the treatment. The dislocation of fibrillarin in cells treated at a lower concentration (0.05 mg/L) of actinomycin D, was totally reversible after removal of the drug from the medium. However, this reversion was not observed at a high drug concentration (1 mg/L). CONCLUSION: Actinomycin D induced dislocation of fibrillarin from nucleoli to nucleoplasm in HEp-2 cells. The retention of fibrillarin within the nucleolus was related to active RNA synthesis. | MinCHEN PingJIANG | 2004 | Acta Pharmacologica Sinica2004，25，7： | 0 |
| 9 | Numerical Simulation of Distribution of VOCs Concentration in the Main Urban Area of Chongqing Based on CALPUFF显示文摘The distribution of VOCs concentration in the main urban area of Chongqing was simulated based on the CALPUFF model.The results show that the long-term contribution of key industrial pollution sources of VOCs in the study area was not significant(0-0.13 mg/m^(3)),and the hourly average instantaneous contribution was significant(the maximum was up to 2.75 mg/m^(3));the hourly average concentration of VOCs in the area where the sensitive points were located rose abruptly at different times(with a maximum of 1.35 mg/m^(3)).The distribution of VOCs concentration in this area was influenced by the dominant wind,and the area where the sensitive points were located was not the area covered by the maximum landing concentration of pollutants.As the dominant wind changed,the pollution situation of the sensitive points may be worsen. | Pingjiang LV Zhenliang LI Min CHEN Dan ZHANG Huachun LI | 2022 | Meteorological and Environmental Research2022，13，4： | 0 |
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