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| 1 | ROS-related Enzyme Expressions in Endothelial Cells Regulated by Tea Polyphenols显示文摘Objective Elevation of reactive oxygen species (ROS), especially the level of superoxide is a key event in many forms of cardiovascular diseases. To study the mechanism of tea polyphenols against cardiovascular diseases, we observed the expressions of ROS-related enzymes in endothelial cells. Methods Tea polyphenols were co-incubated with bovine carotid artery endothelial cells (BCAECs) in vitro and intracellular NADPH oxidase subunits p22phox and p67phox, SOD-1, and catalase protein were detected using Western blot method. Results Tea polyphenols of 0.4 μg/mL and 4.0 μg/mL (from either green tea or black tea) down-regulated NADPH oxidase p22phox and p67phox expressions in a dose-negative manner (P<0.05), and up-regulated the expressions of catalase (P<0.05). Conclusions Tea polyphenols regulate the enzymes involved in ROS production and elimination in endothelial cells, and may be beneficial to the prevention of endothelial cell dysfunction and the development of cardiovascular diseases. | CHEN-JIANGYING XIU-FASUN SHU-LINZHANG XI-PINGZHANG LI-MEIMAO XUE-ZHIZUO PINGYAO | 2004 | Biomedical and Environmental Sciences2004，17，1： | 12 |
| 2 | Induction of Heme Oxygenase-1 in Human Hepatocytes to Protect Them From Ethanol-induced Cytotoxicity显示文摘Background/Aim We investigated the relationship between ethanol exposure and heme oxygenase (HO-1) in human hepatocytes in order to ascertain if induction of HO-1 can prevent ethanol induced cellular damage. Methods Dose-dependent (25-100 mmol/L) and time-dependent (0-24 h) ethanol exposure were used in the present study. HO-1 mRNA and protein expression were detected by PT-PCR and Western blot respectively. HO-1 activity was indicated by bilirubin and Fe2+ formation. Cytotoxicity was investigated by means of lactate dehydrogenate (LDH) and aspartate transaminase (AST) level in culture supernatants, as well as the intracellular formation of malondialdehyde (MDA), cellular glutathione (GSH) status and CYP 2E1 activity. Results We first demonstrated a dose-dependent response between ethanol exposure and HO-1 mRNA and protein expression in human hepatocytes. We further observed a time-dependent increase of HO-1 mRNA expression using 100 mmol/L ethanol starting 30 minutes after ethanol exposure, reaching its maximum between 3 h and 9 h. Being similar to what had been demonstrated with the mRNA level, increased protein expression started at 6 h after ethanol exposure, and kept continuous elevated over 18 h. In addition, we found that ethanol exposure to hepatocytes markedly increased HO-1 enzyme activity in a time-dependent manner measured as bilirubin and Fe2+ formation in human hepatocytes. Our results clearly showed that ethanol exposure caused a significant increase of LDH, AST, and MDA levels, while the antioxidant GSH was time-dependently reduced. Furthermore, we demonstrated that pre-administration of cobalt protoporphyrin (CoPP) induced HO-1 in human hepatocytes, and prevented an increase of MDA and a decrease of GSH. These effects could be partially reversed by zinc protoporphyrin (ZnPP), an antagonist of HO-1 induction. Conclusion HO-1 expression in cells or organs could lead to new strategies for better prevention and treatment of ethanol-induced oxidative damage in human liver. | LIE-GANGLIU HONGYAN WENZHANG PINGYAO XI-PINGZHANG XIU-FASUN ANDREASK.NUSSLER | 2004 | Biomedical and Environmental Sciences2004，17，3： | 5 |
| 3 | External Demand Decline-caused Industry Collapse in China显示文摘工业倒塌在中国的最近的经济生长变化成为了重要现象。这份报纸开发一个简单模型分析这现象。我们的分析在一个外部要求上集中引起衰落的工业倒塌。模型表明在有一条水平国内供应曲线的外部需求的大规模衰落的联合引起国内出口工业在时间的一个短时期在输出经历锋利的减少,它进一步在雇用导致锋利的衰落。常规稳定政策在应付这突然的工业倒塌是不太有效的。提出一条适当结构的工业稳定政策应付突然的工业的中国政府需要崩溃,并且,特别地,编程序实现直接雇用帮助处理源于工业倒塌的失业。 | Pingyao Lai | 2010 | China & World Economy2010，18，1： | 2 |
| 4 | Growth Slowdown in China since 2008: Will There Be a Hard Landing in the Near Future?显示文摘自从 2008 全球金融危机,中国在投资向前见证崭新的大跳跃,并且同时真实的 GDP 生长经历了重要减速自从 2008 ,这份报纸以自从 2008 几乎完全在全部的因素生产率生长来自锋利的减速,它被发现那个中国的生长减速的一个系统的方法用一个生长财务模型检验中国的生长减速直到 2013 在这个时期期间,从扩展投资的生长上的积极效果是完全当前在全部的因素生产率生长由减速的否定效果抵消,中国的经济向下滑动了进 Solow 在这些情形下面的路径,除非中国政府实现,软登陆是完全不能实行的实质重新平衡并且全面、深入的面向市场的改革,由大规模de投资伴随了(在 GDP 在投资的比率减少)并且巨大的雇用调整,中国将是不能的向下避免 Solow 路径,并且在投资的难登陆在不久的将来将不可避免。 | Pingyao Lai | 2015 | China & World Economy2015，23，3： | 2 |
| 5 | A Single‐Enzyme, Two‐Step, One‐Pot Synthesis of N‐Substituted Imidazole Derivatives Containing a Glucose Branch via Combined Acylation/Michael Addition Reaction.显示文摘 | Shi‐PingYao De‐ShuiLu QiWu YingCai Shan‐HaoXu Xian‐‐FuLin | 2005 | ChemInform2005，，5： | 1 |
| 6 | China's Economic Growth: New Trends and Implications显示文摘Since the 'reform and opening up' policy began in 1978,China has sustained high growth.This success is associated with a gradual market-oriented reform.A central feature of this gradual reform is that the dominant state-owned enterprises have not been directly privatized;instead,the government chose to gradually introduce market forces into the economy,and at the same time,gradually reduce restrictions on the development of market-oriented non-stateowned enterprises,especially rural collective enterprises. | Lai Pingyao | 2003 | China & World Economy2003，11，1： | 1 |
| 7 | Green Preparation Process, Characterization and Antitumor Effects of Doxorubicin–BSA–Dextran Nanoparticles显示文摘 | WeiDeng JuanLi PingYao FenHe ChongHuang | 2010 | Macromol Biosci2010，，10： | 1 |
| 8 | LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcription alactivation 显示文摘 | Zeng Pingyao Berger S L | 2006 | Cancer Res2006，15，10： | 1 |
| 9 | Development in China's Foreign Trade:2003-2012显示文摘China 's foreign trade has entered a new stage,marked by some profound changes since2003.After 5 years' consecutive high growth,China'sforeign trade experienced a significant slowdown in growth following the onset of the global financial crisis in 2008.The purpose of this article is to present a review of the development in China's foreign trade over the past10 years,and to explore important changes that have taken place during this period of time.A major finding of the present paper is that the traditional forces driving the high export growth in China,that is,low-cost labor,low-cost resources and low-cost money,have been disappearing.The policy implication is that over the next 10-15 years,the most important conditions for sustaining high export growth will be promoting the development and export of private enterprises in traditional heavy industries and high-technology industries,and relying on technological progress and high productivity to propel export expansion. | Pingyao Lai Qingru Li | 2013 | China & World Economy2013，21，6： | 0 |
| 10 | China's Excessive Investment显示文摘中国的经济在过去的 5 年见证严肃的过多的投资,主要在基础结构和房地产。过多的投资在经济生长和宏观经济的稳定性上有不利影响。这项过多的投资的主要原因是政府投资开销上的不恰当的生长策略,低利率和弱限制。有效地控制过多的投资,中国需要调整它的生长策略,加快利率 marketization 的进程,并且改革存在公共开销系统。 | Pingyao Lai | 2008 | China & World Economy2008，16，5： | 0 |
| 11 | China’s Macroeconomic Development: Stages and Nonlinear Convergence显示文摘The central theme of this paper is that China’s macroeconomic development can be divided into three distinct stages with significant trend changes. Market-oriented reform and opening to the outside world provide main driving forces for the convergence. However, the gradual reform and some inappropriate policies have caused serious ups and downs in China’s macroeconomic performance. | Pingyao Lai | 2006 | China & World Economy2006，14，1： | 0 |
| 12 | China's Housing Market Imbalance from 2003 to 2016: An Analysis Based on the User Cost Approach显示文摘 | Pingyao Lai | 2017 | China & World Economy2017，25，4： | 0 |
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