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| 1 | The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells显示文摘Annulus fibrosus(AF) tissue engineering has recently received increasing attention as a treatment for intervertebral disc(IVD) degeneration; however, such engineering remains challenging because of the remarkable complexity of AF tissue. In order to engineer a functional AF replacement, the fabrication of cell-scaffold constructs that mimic the cellular, biochemical and structural features of native AF tissue is critical.In this study, we fabricated aligned fibrous polyurethane scaffolds using an electrospinning technique and used them for culturing AF-derived stem/progenitor cells(AFSCs). Random fibrous scaffolds, also prepared via electrospinning, were used as a control. We compared the morphology, proliferation, gene expression and matrix production of AFSCs on aligned scaffolds and random scaffolds. There was no apparent difference in the attachment or proliferation of cells cultured on aligned scaffolds and random scaffolds. However, compared to cells on random scaffolds, the AFSCs on aligned scaffolds were more elongated and better aligned, and they exhibited higher gene expression and matrix production of collagen-I and aggrecan. The gene expression and protein production of collagen-II did not appear to differ between the two groups. Together, these findings indicate that aligned fibrous scaffolds may provide a favourable microenvironment for the differentiation of AFSCs into cells similar to outer AF cells, which predominantly produce collagen-I matrix. | Chen Liu Caihong Zhu Jun Li Pinghui Zhou Min Chen Huilin Yang Bin Li | 2015 | Bone Research2015，3，2： | 12 |
| 2 | Phenylfluorenamine-functionalized poly(N-vinylcarbazole)s as dopant-free polymer hole-transporting materials for inverted quasi-2D perovskite solar cells显示文摘In order to improve the efficiency and stability of inverted three-dimensional(3D) or quasi-2D perovskite solar cells(PSCs) for future commercialization, exploring high efficient dopant-free polymer holetransporting materials(HTMs) is still desired and meaningful. One simple and efficient way to achieve high performance dopant-free HTMs is to synthesize novel non-conjugated side-chain polymers via rational molecular design. In this work, N-(4-methoxyphenyl)-9,9-dimethyl-9H-fluoren-2-amine(FMeNPh) groups are introduced into the poly(N-vinylcarbazole)(PVK) side chains to afford two nonconjugated polymers PVCz-DFMeNPh and PVCz-FMeNPh as dopant-free HTMs in inverted quasi-2D PSCs. Benefited from the flexible properties of polyethylene backbone and excellent optoelectronic natures of FMeNPh side-chain groups, PVCz-DFMeNPh with more FMeNPh units exhibited excellent thermal stability, well-matched energy levels and improved charge mobility as compared to PTAA and PVCzFMeNPh. Moreover, the morphologies investigation of quasi-2D perovskite on PVCz-DFMeNPh shows more compact and homogeneous perovskite films than those on PTAA and PVCz-FMeNPh. As a result,the dopant-free PVCz-DFMeNPh based inverted quasi-2D PSCs deliver power conversion efficiency(PCE) up to 18.44% as well as negligible hysteresis and favorable long-term stability, which represents as excellent performance reported to date for inverted quasi-2D PSCs. The results demonstrate the great potentials of constructing non-conjugated side-chain polymer HTMs based on phenylfluorenamine-func tionalized PVK for the development of high efficient and stable inverted 3D or quasi-2D PSCs. | Zhengwu Pan Han Gao Yingying Yang Qin Zou Darui Peng Pinghui Yang Jiangli Cai Jin Qian Jiewei Li Chengrong Yin Nana Wang Renzhi Li Jianpu Wang Wei Huang | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 3 | Effects of coefficient of friction and coefficient of restitution on static packing characteristics of polydisperse spherical pebble bed显示文摘The effects of the coefficient of friction and coefficient of restitution on the static packing characteristics of a polydisperse spherical pebble bed are numerically investigated using the discrete element method.Several important static packing characteristics under different coefficients of friction and restitution are presented and discussed.The results show that the coefficients of friction and restitution impose opposite effects on the packing heights and global packing factor.Neither the coefficient of friction nor restitution affected the oscillation width of the wall,whereas their effects are primarily reflected in the oscillation amplitude of the radial local packing factor and the axial local packing factor distribution at the top of the pebble bed.In both the contact force distribution and coordination number distribution,a left-shifted phenomenon appearing as the coefficient of friction occurred,and only the magnitude of the maximum frequency is affected when the coefficient of restitution changed from 0.1 to 0.9.In all simulation cases,the effects of the coefficients of friction and restitution are similar to that of cross-impact. | Jian Wang Mingzhun Lei Hao Yang Kun Xu Shuling Xu Pinghui Zhao Yuntao Song | 2021 | Particuology2021，19，4： | 0 |
| 4 | Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency显示文摘Forkhead box(Fox)transcription factors play important roles in mammalian development and disease.However,their function in mouse somatic cell reprogramming remains unclear.Here,we report that FoxD subfamily and FoxG1 accelerate induced pluripotent stem cells(iPSCs)generation from mouse fibroblasts as early as day4 while FoxA and FoxO subfamily impede this process obviously.More importantly,FoxD3,FoxD4 and FoxG1 can replace Oct4 respectively and generate iPSCs with germline transmission together with Sox2 and Klf4.On the contrary,FoxO6 almost totally blocks reprogramming through inhibiting cell proliferation,suppressing the expression of pluripotent genes and hindering the process of mesenchymal to epithelial transition(MET).Thus,our study uncovers unexpected roles of Fox transcription factors in reprogramming and offers new insights into cell fate transition. | Meijun Fu Huan Chen Zepo Cai Yihang Yang Ziyu Feng Mengying Zeng Lijun Chen Yue Qin Baomei Cai Pinghui Zhu Chunhua Zhou Shengyong Yu Jing Guo Jing Liu Shangtao Cao Duanqing Pei | 2021 | Cell Regeneration2021，10，1： | 0 |
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