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| 1 | Effect of heat treatment on the structure and properties of poly(2,6-benzothiazole) (ABPBT) and poly (2,5-benzoxazole) (ABPBO)显示文摘 | Wang Shan-feng Bao Gao-bin Lu Zhi-bao Wu Pingping Han Zhe-wen | 2000 | Journal of Materials Science2000，35，： | 1 |
| 2 | RP5-1148A21.3 (lncRP5) exerts oncogenic function in human ovarian carcinoma显示文摘Ovarian cancer(OC)is a fatal gynecological malignancy that is difficult to diagnose at early stages.Various long non-coding RNAs(lncRNAs)are aberrantly expressed in OC and exert regulatory effects on OC;however,the underlying mechanism requires in-depth investigation.This work is designed to explore the molecular regulatory axis of a newly identified lncRNA in OC,that is,lncRNA RP5-1148A21.3(lncRP5).RT-qPCR shows lncRP5 is significantly upregulated in OC patients and cell lines,and it is mainly located in the cytoplasm of OC cells.The results of CCK-8,colony formation,and transwell assays demonstrate that overexpression of lncRP5 greatly contributes to malignant behaviors of OC cells,while inhibition of lncRP5 shows the opposite effects.Moreover,the binding relationship between lncRP5 and miR-545-5p is predicted by bioinformatics and is further verified by luciferase assay.Functionally,the regulatory effects of lncRP5 and miR-545-3p are negatively related;miR-545-5p serves as a tumor suppressor in OC.Further studies demonstrate that PTP4A1 is the target gene of miR-545-5p.Overexpression of PTP4A1 abrogates the inhibitory function of miR-545-5p on OC cell growth and metastasis.The lncRP5/miR-545-5p/PTP4A1 axis is subsequently demonstrated in vivo,and knockdown of lncRP5 notably inhibits tumor growth.This study provides a novel regulatory mechanism of OC,which may contribute to the diagnosis and therapy of OC. | Pingping Sun Aimei Bao Xiangdong Hua Jian Cao Ye Ding | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 1 |
| 3 | The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages显示文摘 | Xiaofeng Bao Jun Cui Yuanyuan Wu Xiaodong Han Cheng Gao Zichun Hua Pingping Shen | 2007 | Journal of Molecular Medicine2007，，1： | 1 |
| 4 | Erratum to“Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker Approach”[Engineering 13(2022)186–196]显示文摘There was a mistake in affiliation a,the correct one should be“MOE Key Laboratory of Marine Genetics and Breeding and Sars-Fang Center,Ocean University of China,Qingdao 266003,China”as updated above;Affiliations c and d should be reversed:Affiliation c should be“Laboratory for Marine Fisheries Science and Food Production Processes,Pilot Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China,”and the affiliation d should be“Laboratory of Tropical Marine Germplasm Resources and Breeding Engineering,Sanya Oceanographic Institution,Ocean University of China,Sanya 572000,China.” | Pingping Liu Jia Lv Cen Ma Tianqi Zhang Xiaowen Huang Zhihui Yang Lingling Zhang Jingjie Hu Shi Wang Zhenmin Bao | 2022 | Engineering2022，，11： | 1 |
| 5 | The effect of alkali-saline stress on the growth of rhizome of Aneurolepidium chinense显示文摘 | BAO GUOZHANG GUAN SHENGCHAO AN PINGPING | 2011 | Mechanic Automation and Control Engineering2011，，7： | 1 |
| 6 | Local bone metabolism balance regulation via double-adhesive hydrogel for fixing orthopedic implants显示文摘The effective osteointegration of orthopedic implants is a key factor for the success of orthopedic surgery.However,local metabolic imbalance around implants under osteoporosis condition could jeopardize the fixation effect.Inspired by the bone structure and the composition around implants under osteoporosis condition,alendronate(A)was grafted onto methacryloyl hyaluronic acid(H)by activating the carboxyl group of methacryloyl hyaluronic acid to be bonded to inorganic calcium phosphate on trabecular bone,which is then integrated with aminated bioactive glass(AB)modified by oxidized dextran(O)for further adhesion to organic collagen on the trabecular bone.The hybrid hydrogel could be solidified on cancellous bone in situ under UV irradiation and exhibits dual adhesion to organic collagen and inorganic apatite,promoting osteointegration of orthopedic implants,resulting in firm stabilization of the implants in cancellous bone areas.In vitro,the hydrogel was evidenced to promote osteogenic differentiation of embryonic mouse osteoblast precursor cells(MC3T3-E1)as well as inhibit the receptor activator of nuclear factor-κB ligand(RANKL)-induced osteoclast differentiation of macrophages,leading to the upregulation of osteogenic-related gene and protein expression.In a rat osteoporosis model,the bone-implant contact(BIC)of the hybrid hydrogel group increased by 2.77,which is directly linked to improved mechanical stability of the orthopedic implants.Overall,this organic-inorganic,dual-adhesive hydrogel could be a promising candidate for enhancing the stability of orthopedic implants under osteoporotic conditions. | Wei Jiang Fushan Hou Yong Gu Qimanguli Saiding Pingping Bao Jincheng Tang Liang Wu Chunmao Chen Cailiang Shen Catarina Leite Pereira Marco Sarmento Bruno Sarmento Wenguo Cui Liang Chen | 2022 | Bioactive Materials2022，7，6： | 0 |
| 7 | Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker Approach显示文摘Targeted genotyping is an extremely powerful approach for the detection of known genetic variations that are biologically or clinically important.However,for non-model organisms,large-scale target geno-typing in a cost-effective manner remains a major challenge.To address this issue,we present an ultrahigh-multiplex,in-solution probe array-based high-throughput diverse marker genotyping(HD-Marker)approach that is capable of targeted genotyping of up to 86000 loci,with coverage of the whole gene repertoire,in what is a 27-fold and six-fold multiplex increase in comparison with the conventional Illumina GoldenGate and original HD-Marker assays,respectively.We perform extensive analyses of var-ious ultrahigh-multiplex levels of HD-Marker(30 k-plex,56 k-plex,and 86 k-plex)and show the power and excellent performance of the proposed method with an extremely high capture rate(about 96%)and genotyping accuracy(about 96%).With great advantages in terms of cost(as low as 0.0006 USD per geno-type)and high technical flexibility,HD-Marker is a highly efficient and powerful tool with broad appli-cation potential for genetic,ecological,and evolutionary studies of non-model organisms. | Pingping Liu Jia Lv Cen Ma Tianqi Zhang Xiaowen Huang Zhihui Yang Lingling Zhang Jingjie Hu Shi Wang Zhenmin Bao | 2022 | Engineering2022，8，6： | 0 |
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